Preparation and evaluation of molecularly imprinted polymer liquid chromatography column for the separation of Cathine enantiomers

Balamurugan, Krishnamoorthy; Gokulakrishnan, K.; Prakasam, Tangirala

doi:10.1016/j.jsps.2011.06.004

Cited by 50 publications

(30 citation statements)

References 37 publications

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“…The commonly used bulk polymerization technology can afford MIPs with irregular size and shape, which has an impact on the chromatographic performance. 491 For instance, Ansell et al…”

Section: 425mentioning

confidence: 99%

Molecular imprinting: perspectives and applications

et al. 2016

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a Molecular imprinting technology (MIT), often described as a method of making a molecular lock to match a molecular key, is a technique for the creation of molecularly imprinted polymers (MIPs) with tailor-made binding sites complementary to the template molecules in shape, size and functional groups. Owing to their unique features of structure predictability, recognition specificity and application universality, MIPs have found a wide range of applications in various fields. Herein, we propose to comprehensively review the recent advances in molecular imprinting including versatile perspectives and applications, concerning novel preparation technologies and strategies of MIT, and highlight the applications of MIPs. The fundamentals of MIPs involving essential elements, preparation procedures and characterization methods are briefly outlined.Smart MIT for MIPs is especially highlighted including ingenious MIT (surface imprinting, nanoimprinting, etc.), special strategies of MIT (dummy imprinting, segment imprinting, etc.) and stimuli-responsive MIT (single/dual/ multi-responsive technology). By virtue of smart MIT, new formatted MIPs gain popularity for versatile applications, including sample pretreatment/chromatographic separation (solid phase extraction, monolithic column chromatography, etc.) and chemical/biological sensing (electrochemical sensing, fluorescence sensing, etc.). Finally, we propose the remaining challenges and future perspectives to accelerate the development of MIT, and to utilize it for further developing versatile MIPs with a wide range of applications (650 references).

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“…The commonly used bulk polymerization technology can afford MIPs with irregular size and shape, which has an impact on the chromatographic performance. 491 For instance, Ansell et al…”

Section: 425mentioning

confidence: 99%

Molecular imprinting: perspectives and applications

et al. 2016

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“…Devido à necessidade de maceração, as partículas finais apresentam tamanho homogêneo, porém, formato irregular [43] . Relatos na literatura apresentam a utilização deste tipo de polimerização para a obtenção de MIPs empregados em diversas técnicas de preparo de amostras, tais como SPE, SPME, entre outras [52,53,59] .…”

Section: Metodologias De Sínteseunclassified

Emprego de polímeros de impressão molecular em preparo de amostras para análise de compostos orgânicos: aplicações e tendências

Santos¹,

Abrão²,

Freitas³

et al. 2012

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ResumoOs polímeros de impressão molecular são materiais sintéticos dotados de sítios específicos de reconhecimento. Esses materiais são obtidos por reações de polimerização que fixam, estrategicamente, monômeros funcionais ao redor de uma molécula modelo de acordo com os grupos ligantes e com a estereoquímica de ambas as moléculas. Os MIPs têm sido amplamente empregados em procedimentos de preparo de amostras, como extração e microextração em fase sólida, extração sortiva em barra de agitação, extração com adsorvente magnético, microextração com sorvente empacotado, entre outras. Este artigo de revisão tem como objetivo apresentar o que há de mais recente no emprego de MIP para extração de compostos orgânicos, evidenciando as vantagens de cada aplicação, bem como as mais promissoras tendências que sustentam a evolução e o aperfeiçoamento de cada técnica. Palavras-chavePolímeros de impressão molecular; MIP; preparo de amostras.Molecularly imprinted polymers in sample preparation for organic compounds analysis: applications and trends AbstractMolecularly imprinted polymers are synthetic materials with molecular recognition ability. These materials are obtained by polymerization reactions that fix the functional monomers around the template molecule according with the binding groups and the stereochemistry of both molecules. The MIPs have been extensively used in several applications with emphasis for sample preparation procedures as solid phase extraction, solid phase microextraction, extraction by magnetic sorbents, microextraction by packed sorbent among others. So, the objective of this review is to present the novelty in MIP use for organic compounds extraction and point out the advantages of each application, as well as what is most promising in the evolution and improvement of each technique.

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“…Molecularly imprinted polymers have recently attracted the interest of many researchers as a remarkable type of chiral stationary phases that are effectively employed in the chiral separation of numerous racemic mixtures . In the last few years, this technique has presented promising results in the preparation of specific groups of smart polymers with very high enantio‐selective properties that enable the separation of targeted specific enantiomers coexisting with their mirror images .…”

Section: Introductionmentioning

confidence: 99%

Surface molecular imprinting of nylon fibers for chiral recognition of d‐phenyllactic acid

Bukhari

Monier

Elsayed

2019

Polymer International

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In the current work, synthetic polyamide nylon fibers were modified via the strategy of surface molecular imprinting to develop enantio-selective adsorbent fabrics for chiral recognition of D-phenyllactic acid (D-PhLA). The nylon fibers were first modified by grafting of polyacrylamide and then the incorporated amide groups were converted into functional amino groups via treatment with NaOCl (Hofmann degradation). The amino-functionalized nylon fibers (Ny-NH 2 ) were interacted with the targeted D-PhLA enantiomer before crosslinking the amino-containing grafted chains with glutaraldehyde crosslinker followed by leashing the template D-PhLA out of the formed surface polymeric matrix by lowering the pH to 1 to finally produce the desired enantio-selective adsorbent fibers DP-Ny. Different instrumental methods such as elemental analysis, Fourier transform infrared spectroscopy, XRD and TGA were employed to examine all the synthetic procedures. SEM was also utilized to observe the morphological appearances of both native and modified nylon fibers. Moreover, the optimum extraction of D-PhLA was found to occur at pH 7. Isotherm studies of the prepared DP-Ny fibers obeyed the common Langmuir linear equation with q m values 130 ± 2 and 75 ± 1 mg g −1 in the case of D-PhLA and L-PhLA, respectively. Furthermore, the enantiomeric resolution of (±)-PhLA racemate was successfully carried out by a column technique with enantiomeric excess reaching approximately 78%.

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Preparation and evaluation of molecularly imprinted polymer liquid chromatography column for the separation of Cathine enantiomers

Cited by 50 publications

References 37 publications

Molecular imprinting: perspectives and applications

Molecular imprinting: perspectives and applications

Emprego de polímeros de impressão molecular em preparo de amostras para análise de compostos orgânicos: aplicações e tendências

Surface molecular imprinting of nylon fibers for chiral recognition of d‐phenyllactic acid

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