Preparation and evaluation of niosomes containing autoclaved<i>Leishmania major</i>: a preliminary study

Pardakhty, Abbas; Shakibaie, Mojtaba; Daneshvar, Hamid; Khamesipour, Ali; Mohammadi-Khorsand, Tayebe; Forootanfar, Hamid

doi:10.3109/02652048.2011.642016

Cited by 52 publications

(22 citation statements)

References 33 publications

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“…We have observed that the amount and the chain length of the ionic surfactants, play a key role in modifying the arrangements of the bilayer . Charged surfactants in the bilayer lead to increase in the curvature, thereby altering the size of the vesicles . The change in the size of the niosome leads to change in the area of the vesicular compartments.…”

Section: Introductionmentioning

confidence: 99%

Deciphering the Role of Bilayer of a Niosome towards Controlling the Entrapment and Release of Dyes

2018

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Niosomes are self-assemblies of non-ionic surfactants into vesicular structures, which mimic cell membranes in several aspects and potentially used as transdermal carriers for hydrophilic or hydrophobic drugs. However, controlling the amount of prescribed drug is absolutely important during transdermal delivery. The drug entrapment in a niosome, depends on several factors such as the bilayer arrangement, size and surface charge of a particular niosome. Hence, a systematic synthetic and spectroscopic study will convey the important information about drug entrapment and even controlling the entrapment, upon structural variation of the niosomes. In this report, we show that how the hydrophobic bilayer arrangement can be crucial to alter the molecular entrapment inside the niosome.For such study, niosomes are synthesized, which contain bilayers of different capacities. Entrapment and release studies are performed subsequently using common fluorophores: coumarin-153 (a hydrophobic dye) and rhodamine 6G (a water loving dye). Raman Spectroscopy is extensively used to characterize the bilayer disorderness for the synthesized niosomes. Our study reveals, that the niosome with ordered bilayer can entrap the hydrophobic dye coumarin-153 significantly more than the niosome containing a disordered bilayer. However, we have also identified that these entrapment efficiencies of the niosomes are reversed in a substantial way by the addition of ionic surfactants like CTAB, to the niosome. -pilani.ac.in [b] Dr.

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Section: Introductionmentioning

confidence: 99%

Deciphering the Role of Bilayer of a Niosome towards Controlling the Entrapment and Release of Dyes

2018

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“…Niosomal sodium stibogluconate was shown to be more effective than liposomal vesicular formulations and free drug against experimental murine visceral leishmaniasis [73,96]. More recently, in vivo studies demonstrated that the niosomes containing autoclaved L. major have a significant result in the prevention of cutaneous leishmaniasis in BALB/c mice [97]. Furthermore, vaccination of C57BL/10 mice specifies that subcutaneous vaccination against cutaneous leishmaniasis with purified gp63 entrapped into niosomes, encouraged considerable resistance to this disease [98].…”

Section: Current Antileishmanial Drug-delivery Systemsmentioning

confidence: 97%

Drug Resistance in Leishmaniasis: Current Drug-Delivery Systems and Future Perspectives

et al. 2013

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Leishmaniasis is a complex of diseases with numerous clinical manifestations for instance harshness from skin lesions to severe disfigurement and chronic systemic infection in the liver and spleen. So far, the most classical leishmaniasis therapy, despite its documented toxicities, remains pentavalent antimonial compounds. The arvailable therapeutic modalities for leishmaniasis are overwhelmed with resistance to leishmaniasis therapy. Mechanisms of classical drug resistance are often related with the lower drug uptake, increased efflux, the faster drug metabolism, drug target modifications and over-expression of drug transporters. The high prevalence of leishmaniasis and the appearance of resistance to classical drugs reveal the demand to develop and explore novel, less toxic, low cost and more promising therapeutic modalities. The review describes the mechanisms of classical drug resistance and potential drug targets in Leishmania infection. Moreover, current drug-delivery systems and future perspectives towards Leishmaniasis treatment are also covered.

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“…The gelation was considered successful, if the samples did not flow under gravity when the vials were inverted. [28,29] The CGC was found to be 18% (w/w) and 20% (w/w) for MO and GO, respectively. The MO gels containing 18% (w/w) SM were not stable after one month of storage at RT.…”

Section: Antimicrobial Studiesmentioning

confidence: 98%

Development of mustard oil- and groundnut oil-based span 40 organogels as matrices for controlled drug delivery

Satapathy

Sagiri

Pal

et al. 2013

Designed Monomers and Polymers

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The present study deals with the development and characterization of sorbitan monopalmitate (SM) organogels using mustard oil (MO) and groundnut oil (GO) as the apolar phase. In both the cases, the organogels containing ≥ 20% (w/w) SM were found to be stable for prolonged period. The microscopic studies showed the presence of aggregates of tubular shaped gelator fibers in the gel architecture. Fourier transform infrared spectroscopy indicated formation of intermolecular hydrogen bonding amongst the oil and gelator molecules. Differential scanning colorimetry studies indicated that the thermal stability of GO organogels was found to be more than the MO organogels. Gels showed pseudoplastic flow, with shear thinning and thixotropic behavior. The drug release from the organogels followed Higuchian kinetics with non-Fickian diffusion. The pH values of organogels were found to be near the human skin pH and highly hemocompatible. Metronidazole loaded organogels have shown good antimicrobial activity against Bacillus subtilis. Based on the preliminary studies, the developed organogels may be tried as drug carriers.

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Preparation and evaluation of niosomes containing autoclavedLeishmania major: a preliminary study

Cited by 52 publications

References 33 publications

Deciphering the Role of Bilayer of a Niosome towards Controlling the Entrapment and Release of Dyes

Deciphering the Role of Bilayer of a Niosome towards Controlling the Entrapment and Release of Dyes

Drug Resistance in Leishmaniasis: Current Drug-Delivery Systems and Future Perspectives

Development of mustard oil- and groundnut oil-based span 40 organogels as matrices for controlled drug delivery

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