Preparation and Evaluation of NovelIn SituGels Containing Acyclovir for the Treatment of Oral Herpes Simplex Virus Infections

Abstract

The objective of this work was to develop an oral mucosal drug delivery system to facilitate the local and systemic delivery of acyclovir for the treatment of oral herpes infection caused by the herpes simplex virus (HSV). An in situ gelling system was used to increase the residence time and thus the bioavailability of acyclovir in oral mucosa. Temperature and pH trigged in situ gel formulations were prepared by cold method using polymers like poloxamer 407, carbopol 934, and HPMC. Glycerin and a mixture of tween 80 and ethanol (1 : 2 ratio) were used as the drug dissolving solvent. The pH of carbopol containing formulation was adjusted to pH 5.8 while the pH of poloxamer solution was adjusted to pH 7. These formulations were evaluated for sol-gel transition temperature, gelling capacity, pH, viscosity, spreadability, gel strength, drug content, ex-vitro permeation, and mucoadhesion. The gelation temperatures of all the formulations were within the range of 28–38°C. All the formulations exhibited fairly uniform drug content (98.15–99.75%). Drug release study of all the formulations showed sustained release properties. The release of drug through these in situ gel formulations followed the Higuchi model and Korsmeyer peppas model mechanism.

Effects of Lipids and Emulsifiers on the Physicochemical and Sensory Properties of Cosmetic Emulsions Containing Vitamin E

“…The determination of spreadability was performed according to the method described by Chaudhary and Verma [21]. Briefly, 1 g of sample was placed between two glass slides (diameter = 20 cm).…”

Development and Optimization of Sustained Release in Situ Gel for the Treatment of Ulcerative Colitis

“…[2] Ulcerative colitis is a disease that causes inflammation and sores (ulcers) in the lining of the large intestine (colon). It usually affects the lower section (sigmoid solon) and the rectum.…”

Utilization of nanotechnology to enhance percutaneous absorption of acyclovir in the treatment of herpes simplex viral infections

“…The decrease in the spreadability of the hydrogel from 3.9 in F6 to 3.7 in F9 was also confirmed when the concentration of chitosan was increased, which may be attributed to the increased viscosity of the hydrogel, and is in accordance with previous work in which an oral mucosal gel was developed to facilitate local and systemic delivery of ACV for the treatment of oral herpes infection. 25 effects on percent of acV permeated (Y 2 )…”

“…The technique previously published by Chaudhary and Verma was implemented, with slight modification. 25 The permeation pattern for ACV was determined by plotting the cumulative amount of the drug permeated (Q) per unit area as a function of time. The steady-state flux was calculated from the slope.…”