Preparation and Evaluation of Phytosomes of Pomegrane Peels

Pande, S. D.; Wagh, Anita S.; Bhagure, L.B.; Patil, Swati; Deshmukh, A. R.

doi:10.5958/0974-360x.2015.00070.0

Cited by 12 publications

(2 citation statements)

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“…The powdered physical mixture complex was filled in amber colored glass bottle container and kept in the refrigerator. [11][12][13][14][15]…”

Section: Antisolvent Precipitation Techniquementioning

confidence: 99%

Formulation and Evaluation of Phytosomes of Hydroalcoholic Extract of Adiantum capillus-veneris for Antimicrobial Activity

Jagtap,

Kajale,

Abhyankar

et al. 2023

Pharmacogn. Res.

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Background: Natural plant extracts and phytoconstituents have high in vitro bioactivity but low in vivo bioactivity because of poor lipid solubility, multiple ring large molecules, or digestion in the gut. Polyphenolic phytoconstituents were complexed with phospholipids, mainly phosphatidylcholine, which molecularly attaches components to one another to produce novel drug delivery systems like phytosomes. The important constituents of the herbal extract are designed to protect from being disrupted by gastric juices and gut bacteria, as phytosomes have the ability to cross the bio-membranes that which are lipid enriched and boost bioavailability. Objectives: The current work is aimed to formulate and evaluate phytosomes from Adiantum capillus-veneris (ACV) hydroalcoholic extract for antimicrobial activity. Materials and Methods: Antisolvent precipitation method was chosen on the basis of the solubility of hydroalcoholic extract in dichloromethane. The prepared trial batches of the phytosomes complex were characterized by using particle size, zeta potential, drug entrapment efficiency, drug content, and in vitro drug release study. The optimized batch of phytosomes was characterized for compatibility studies by using Infrared Spectrometry (IR), Transmission Electron Microscopy (TSM), Differential Scanning Calorimetry (DSC), and further for stability studies. Results: The results revealed that ACV hydroalcoholic extract and phosphatidylcholine were found to be connected by a non-covalent bond and did not generate a new molecule in the ACV hydroalcoholic extract-phosphatidylcholine complex and showed enhanced in vitro antimicrobial activity as compared to the hydroalcoholic extract. Conclusion: The complex's dissolution profile was found to be improved. As a result, the phospholipid complex of ACV extract can therefore be concluded to have the potential to enhance bioavailability.

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“…The powdered physical mixture complex was filled in amber colored glass bottle container and kept in the refrigerator. [11][12][13][14][15]…”

Section: Antisolvent Precipitation Techniquementioning

confidence: 99%

Formulation and Evaluation of Phytosomes of Hydroalcoholic Extract of Adiantum capillus-veneris for Antimicrobial Activity

Jagtap,

Kajale,

Abhyankar

et al. 2023

Pharmacogn. Res.

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“…and the polar head regions of phospholipids (phosphatidylcholine, etc.) [ 213 , 214 ]. Phytosomes have been shown to increase the absorption of phytocompounds or plant extracts, resulting in improved biological activity.…”

Section: Current Lipid- and Inorganic-based (Metal Or Metal Oxide) Na...mentioning

confidence: 99%

An Overview of Herbal-Based Antidiabetic Drug Delivery Systems: Focus on Lipid- and Inorganic-Based Nanoformulations

et al. 2022

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Diabetes is a metabolic pathology with chronic high blood glucose levels that occurs when the pancreas does not produce enough insulin or the body does not properly use the insulin it produces. Diabetes management is a puzzle and focuses on a healthy lifestyle, physical exercise, and medication. Thus far, the condition remains incurable; management just helps to control it. Its medical treatment is expensive and is to be followed for the long term, which is why people, especially from low-income countries, resort to herbal medicines. However, many active compounds isolated from plants (phytocompounds) are poorly bioavailable due to their low solubility, low permeability, or rapid elimination. To overcome these impediments and to alleviate the cost burden on disadvantaged populations, plant nanomedicines are being studied. Nanoparticulate formulations containing antidiabetic plant extracts or phytocompounds have shown promising results. We herein aimed to provide an overview of the use of lipid- and inorganic-based nanoparticulate delivery systems with plant extracts or phytocompounds for the treatment of diabetes while highlighting their advantages and limitations for clinical application. The findings from the reviewed works showed that these nanoparticulate formulations resulted in high antidiabetic activity at low doses compared to the corresponding plant extracts or phytocompounds alone. Moreover, it was shown that nanoparticulate systems address the poor bioavailability of herbal medicines, but the lack of enough preclinical and clinical pharmacokinetic and/or pharmacodynamic trials still delays their use in diabetic patients.

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