Preparation and Evaluation of Ternary Polymeric Blends for Controlled Release Matrices Containing Weakly Basic Model Drug

Abstract

Objective: The objective of this study was to evaluate the suitability of ternary mixture of smart polymers comprised of Eudragit®E100, Eudragit®L100, and sodium alginate to serve as a carrier for sustained drug release for weakly basic drugs. The model drug chosen in this part of the study is Metronidazole. Methods: Matrix tablets formulations were prepared by either direct compression or by wet granulation. Dissolution studies were conducted using USP XXΠ rotating paddle apparatus in three different consecutive stages (pH 1.2, 4.8 and 6.8). Tablets made of low to intermediate proportions of sodium alginate and an approximately equal proportions of Eudragit®E100 and Eudragit®L100 were found to have significant modification of drug release rates. Result: Thus, indicating a potential for controlling the drug release for 12 hours depending on polymers ratios in the formulation. The ratio of sodium alginate to total Eudragit® polymers and the ratio of Eudragit®E100 to Eudragit®L100 within the ternary polymeric composition were found critical in determining the controlled release performance. Conclusion: Results of swelling studies were in agreement with the dissolution behaviors of the tablets. The findings suggest the significance of the ternary polymeric compositions in controlling the release of weakly basic drug.

Hybrid Films Prepared from a Combination of Electrospinning and Casting for Offering a Dual-Phase Drug Release

“…The casting films often have a solid inner structure, which determines that the encapsulated drug molecules have a long way to diffuse for dissolution, and thus, a fine sustained release profile is achieved accordingly [ 50 , 51 ]. The drug sustained release profiles not only benefit the patients with reduced administration times being ensured, but also can keep a constant blood drug concentration, and thus, a safer therapeutic effect [ 52 , 53 , 54 ].…”

Formulation and evaluation of mucoadhesive buccal tablet of Anastrozole

“…This leads to intermolecular H-bonding, which causes entrapment of a drug inside the cross-linked network of the polymer [30]. The method of preparation effect was studied in F4, F6, greater retardation effect was obtained in F6 which is due to the coating of drug particles by carbopol and Na alginate, drug granulation process which in turn slow down the penetration of water into granules and diminish the direct contact with the dissolution medium [31]. As for the F5, in which the effect of addition PVP as a co-binder was studied, decreasing in the cumulative percentage of release was noticed when compared with F4, this may due to the binding effect of PVP that resulted in increasing the mechanical strength (hardness) of the tablets which lead to reducing the drug release [30,31].…”

Development of a Novel, Ecologically Friendly Generation of pH-Responsive Alginate Nanosensors: Synthesis, Calibration, and Characterisation

“…Therefore, there is an ecological need to formulate new nanosensors that are biocompatible, biodegradable, environmentally safe, and ecologically friendly. Accordingly, this study aimed to design novel, safe, and eco-friendly pH-responsive nanosensors consisting of pH-sensitive fluorophores covalently attached to an alginate polysaccharide, which is a non-toxic, biodegradable, biocompatible, and natural polymer, using the ionic gelation method [46][47][48][49], which is an organic, solvent-free method that primarily relies on using a divalent cation as the cross-linking agent, thus producing such a new generation of ecofriendly pH nanosensors, which could be safely employed in biosensing applications in the future, eliminating any environmental hazards imposed by the existing pH nanosensors.…”