Preparation and evaluation of trans-resveratrol NanoSolve

Fang, Qiao; Ma, Chaolong; Xia, Qiang

doi:10.1080/10584587.2016.1162131

Cited by 3 publications

(3 citation statements)

References 7 publications

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“…For instance, HA coated nanoemulsions confirmed the skin penetration of RSV through ex vivo sheep nasal mucosal and showed a RSV flux of 2.86 μg/cm 2 h. [25] In vitro permeation analysis measured in porcine skin at 37°C showed that only 21 % of RSV was penetrated from ethanol solution, whereas 82 % was released from RSV-emulsion (with 2-HP-β-CD) evidencing its good skin compatibility (Figure 22). [26] It is worth mentioning that a higher cumulative amount of RSV-SNEDDS (composed of sodium lignin sulfonate/Tween 80/ PEG-400 as mixed surfactants and olive oil) was transported, from the apical-to-basolateral direction through Caco-2 cells monolayers, than from pure RSV solution. [33] Similarly, the permeability of the encapsulated RSV in MCM-48 nanospheres across tight junctions of Caco-2 monolayers was more than 5 times higher than for RSV suspension.…”

Section: Penetration and Permeation Studiesmentioning

confidence: 99%

“…In contrast, Fang and co-workers prepared a RSV delivery system based on emulsions to improve stability and water solubility of RSV. [26] The emulsion is formed by 2-hydroxypropylβ-cyclodextrin (2-HP-β-CD), phosphatidyl choline 60 and a solution of soybean phospholipid dipropylene glycol (15 % w/ w). The RSV-emulsion formulation was prepared by highpressure homogenization method using 3 % (w/w) of trans-RSV in a glycerin : water (8 : 2) mixture.…”

Section: Simple Emulsionsmentioning

confidence: 99%

“…Fang and co-workers prepared a transparent microemulsion using high-pressure homogenization method whereby the resulting pre-emulsion is passed through a homogenizator at a pressure of 800 bar up to 4 cycles and at 80°C. [68] Matos and co-workers prepared microemulsions by high shear homogenization method using high agitation rate in short time (20000 rpm for 1 min). [32] In 2017, Kumar and co-workers prepared nanoemulsions using ultrasonic emulsification technology.…”

Section: Single Emulsionsmentioning

confidence: 99%

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Recent Strategies in Resveratrol Delivery Systems

2019

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Resveratrol, a natural polyphenolic stilbenoid widely found in grapes and wines, displays beneficial properties such as cardio‐protective, antioxidant and anti‐inflammatory activities. Trans‐resveratrol (RSV) is the most bioactive and more abundant stereoisomer found in nature. Despite the positive properties of RSV, there are various factors that limit its effectiveness, including low aqueous solubility, low oral bioavailability and chemical instability. During the last years, an increasing number of strategies such as nano and micro encapsulation have been developed in order to overcome these limitations and enhance the use of RSV in nutritional and pharmaceutical applications. This Review summarizes the advances and main properties of several RSV carriers and delivery systems reported during the last 5 years.

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Section: Penetration and Permeation Studiesmentioning

confidence: 99%

Section: Simple Emulsionsmentioning

confidence: 99%

Section: Single Emulsionsmentioning

confidence: 99%

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Recent Strategies in Resveratrol Delivery Systems

2019

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Optimisation and Characterisation of Improved Nanoemulsion Formulations Containing Ceramide 3

Xu,

Liu,

Zhu

et al. 2024

ChemNanoMat

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Ceramide3 (Cer3) is one of the important components of stratum corneum (SC) lipids with good moisturizing and repairing properties. However, it suffers from (a) poor solubility, (b) easy crystallization and precipitation, and (c) strong polarity and difficulty in transdermal application. This study aimed to load Cer3 into nanoemulsions (NEs) to overcome these mentioned defects. The optimized NEs formulation was prepared by high pressure homogenization method and characterized by several methods. The optimized ceramide3 nanoemulsions(Cer3‐NEs) exhibited a good physico‐chemical stability over 3 months under different conditions, with droplet size of 103.1 nm, PDI of 0.178, zeta potential of ‐39.09 mV, pH of 6.20 and encapsulation efficiency of 96.39%. Turbiscan results showed that formulations containing Cer3‐NEs have better stability than those containing free Cer3. The dermal delivery ability of Cer3‐NEs was assessed by Franz diffusion and confocal Raman spectroscopy (CRM). In vitro and in vivo penetration studies showed that Cer3‐NEs serum have almost 2‐3 times higher retention in the skin and permeation in the receptor solution compared to serum with free Cer3. The findings show NE is a promising carrier of Cer3 for topical administration in the treatment of dryness and barrier damage due to higher stability and better skin permeability.

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Nose-to Brain Delivery of Resveratrol, a Non-Invasive Method for the Treatment of Cerebral Ischemia

Alquisiras-Burgos,

González-Herrera,

Alcalá-Alcalá

et al. 2024

DDC

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Cerebral ischemia represents a particular condition among neurological diseases due to its high frequency, high associated mortality, and the permanent disability in patients that survive it. Numerous studies in animal models have demonstrated the protective properties of resveratrol against cerebral ischemia. Resveratrol is a soluble molecule in polar solvents with high membrane permeability; however, it is rapidly metabolized at the liver and is also a substrate of the ATP binding cassette transporters located at the blood–brain barrier. These circumstances reduced bioavailability of resveratrol to the brain. In this review, we examined nasal resveratrol’s formulations including nanocarriers such as nanostructured lipid carriers, nanoemulsions, nanoparticles, bilosomes, cubosomal, and transferosomes that are directly transported to the brain. An intranasal administration route evades resveratrol transformation due to liver metabolism. Components of nanoformulations increased resveratrol absorption to the brain by enhancing permeation through specific approaches and also maintaining stability during storage. Both characteristics improved the delivery of resveratrol with conserved antioxidant capacity and protective properties for neurological models. Although demonstration that the nanoformulations prevents resveratrol’s blood–brain barrier retention is missing, properties of resveratrol’s nanoformulation encourage testing in clinical trials; however, regulatory approval for a novel nanocarrier in nasal drug delivery is complicated and needs approval.

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Preparation and evaluation of trans-resveratrol NanoSolve

Cited by 3 publications

References 7 publications

Recent Strategies in Resveratrol Delivery Systems

Recent Strategies in Resveratrol Delivery Systems

Optimisation and Characterisation of Improved Nanoemulsion Formulations Containing Ceramide 3

Nose-to Brain Delivery of Resveratrol, a Non-Invasive Method for the Treatment of Cerebral Ischemia

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