Preparation and hemocompatibility of electrospun O‐carboxymethyl chitosan/PVA nanofibers

Abstract

Chitosan was deacetylated and carboxymethylated to prepare O‐carboxymethyl chitosan (CMC) for further electrospinning. CMC was characterized using FTIR, NMR, and chemical titration, indicating a degree of carboxymethylation of 51.4%. CMC was electrospun together with poly(vinyl alcohol) (PVA) to prepare membranes composed of nanofibers. The electrospinning conditions were optimized. The CMC/PVA membrane obtained at the conditions of 15.2 g/mL CMC 50 mL, 8 g/mL PVA 5 mL, 25 kV, and a distance of 23 cm, had nanofibers without beads, with diameters of 70–200 nm. The mats were crosslinked by glutaraldehyde before platelet adhesion measurement. The nanofibrous structure remained after crosslinking while the wettability decreased. CMC/PVA mats with higher CMC amount and fewer beads, had fewer adherent platelets and less platelets aggregation showing better hemocompatibility. © 2016 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2016, 133, 43565.

Electrospun Nanofibrous Wound Dressings: A Review on Chitosan Composite Nanofibers as Potential Wound Dressings

“…Synthetic polymers that are nontoxic, biodegradable, and have suitable physicochemical and mechanical properties with proven applications in the biomedical field are generally selected for electrospinning nanofibers. Some of these polymers include polycaprolactone (PCL) [49], polyethylene glycol (PEG) [50], polyethylene oxide (PEO) [51], polylactide (PLA) [52], poly-L-lactic acid (PLLA) [53], poly (lactic-co-glycolic acid) (PLGA) [54], polyvinyl alcohol (PVA) [55].…”

Marine Biopolymers as Bioactive Functional Ingredients of Electrospun Nanofibrous Scaffolds for Biomedical Applications

“…Alipour et al (2009) prepared quaternized chitosan/PVA electrospun nanofibers [ 156 ]. The carboxymethylation of the amino and hydroxyl groups of chitosan generates a water-soluble derivative of chitosan, and electrospun nanofibers of carboxymethyl chitosan have been developed successfully, with very promising results for biomedical applications due to their enhanced hydrophilicity, biocompatibility, and hemocompatibility [ 157 , 158 ].…”

Expanding the Repertoire of Electrospinning: New and Emerging Biopolymers, Techniques, and Applications

“…[15][16][17] Also, due to their solubility in different solvents and different structural behavior in solution, biopolymers are extensively used for scaffolds and fiber formation by electrospinning, and have shown promising biological properties, such as cytocompatibility for different cell phenotypes, enhanced blood coagulation for applications as wound dressings, enhanced antibacterial activity, and absorption capacity for dyes and other molecules. [1,18,19] In this review, we focus on the recent developments in electrospinning technology. In particular, we describe new fibers produced from emerging biopolymers with features that impart useful biochemical function, including sulfated polysaccharides (carrageenans and glycosaminoglycans), tannins and their derivatives (condensed and hydrolyzed tannins, tannic acid), modified collagens, and extracellular matrix (ECM) extracts.…”