Preparation and In Vitro/In Vivo Evaluation of the Buccal Bioadhesive Properties of Slow-Release Tablets Containing Miconazole Nitrate

Mohammed, F. A.; Khedr, Hussin

doi:10.1081/ddc-120018206

Cited by 53 publications

(21 citation statements)

References 22 publications

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“…The swelling behavior of dosage unit can be measured either by studying its dimensional changes, weight gain, or water uptake (22,23). Water uptake study of the dosage form is conducted by using USP dissolution apparatus-II in 900 ml of distilled water which is maintained at 37±0.5°C, rotated at 50 rpm.…”

Section: Water Uptake Studiesmentioning

confidence: 99%

Formulation and Evaluation of Swellable and Floating Gastroretentive Ciprofloxacin Hydrochloride Tablets

2009

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Abstract. Drugs that have narrow absorption window in the gastrointestinal tract (GIT) will have poor absorption. For these drugs, gastroretentive drug delivery systems offer the advantage in prolonging the gastric emptying time. Swellable, floating, and sustained release tablets are developed by using a combination of hydrophilic polymer (hydroxypropyl methylcellulose), swelling agents (crospovidone, sodium starch glycolate, and croscarmelose sodium) and effervescent substance (sodium bicarbonate). Formulations are evaluated for percentage swelling, in vitro drug release, floating lag time, total duration of floating, and mean residence time (MRT) in the stomach. The drug release of optimized formulation follows the Higuchi kinetic model, and the mechanism is found to be non-Fickian/anomalous according to Krosmeyer-Peppas (n value is 0.68). The similarity factor (f 2 ) is found to be 26.17 for the optimized formulation, which the release is not similar to that of marketed produced (CIFRAN OD®). In vivo nature of the tablet at different time intervals is observed in the radiographic pictures of the healthy volunteers and MRT in the stomach is found to be 320±48.99 min (n=6). A combination of HPMC K100M, crospovidone, and sodium carbonate shows the good swelling, drug release, and floating characters than the CIFRAN OD®.

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Section: Water Uptake Studiesmentioning

confidence: 99%

Formulation and Evaluation of Swellable and Floating Gastroretentive Ciprofloxacin Hydrochloride Tablets

2009

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“…The differences in the swelling rate of the buccal film formulations did not change the drug release mechanisms. [24][25][26] The sustained release rate (Kϭ13.71) among all the batches was shown by batch SSB1 containing 24% ratio of CP 940P (Table 5). This batch showed maximum bioadhesive force with moderate swelling rate (Tables 3, 4).…”

Section: Mechanical Properties and Bioadhesive Forcementioning

confidence: 99%

In Vitro and in Vivo Evaluation of Buccal Bioadhesive Films Containing Salbutamol Sulphate

Singh

Soni

Rawat

et al. 2010

CHEMICAL & PHARMACEUTICAL BULLETIN

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The aim of present study was to prepare and evaluate buccal bioadhesive films of salbutamol sulphate (SS) for the treatment of asthma. The films were designed to release the drug for a prolonged period of time so as to reduce the frequency of administration of the available conventional dosage forms of SS. The different proportions of sodium carboxymethylcellulose (SCMC) and Carbopol 940P (CP 940P) were used for the preparation of films. Carbopol was used to incorporate the desired bioadhesiveness in the films. The films were prepared by solvent casting method and evaluated for bioadhesion, in vitro drug release and anti asthmatic effect (bronchoprotection) in histamine induced bronchospasm of guinea pigs. In vitro drug release from the film was determined using a modified Franz diffusion cell while bioadhesiveness was evaluated with a modified two-arm balance using guinea pig buccal mucosa as a model tissue. Films containing SCMC : CP 940P ratio of 76 : 24 was found to be the best with moderate swelling along with favorable bioadhesion force and in vitro drug release. The drug release mechanism was found to follow non-Fickian diffusion as release mechanism. The prolonged in vivo effect (bronchoprotection) obtained from the buccal bioadhesive film of SS administered via buccal route may improve the treatment of asthmatic disorders by reducing the frequency of administration which is associated with the tolerance effect of SS. Additionally for the clinical benefit, it is also expected to reduce the major adverse effects of SS such as tachycardia and arrhythmias via buccal absorption.Key words salbutamol sulphate; buccal bioadhesive film; Carbopol 940P; in vivo effect Chem. Pharm. Bull. 58(3) 307-311 (2010)

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“…The swelling behavior of 9 runs studied in triplicate for their dimensional changes, weight gain, or water uptake ability as described by Mohammed et al [29] SI measurement was carried out by placing a weighed tablet (W 0 ) in 200 ml of 0.1 N HCl in a beaker, which was maintained at 37 ± 0.5°C. At selected intervals, the tablet was withdrawn, and excess surface water was removed with filter paper and reweighed (W t ).…”

Section: Simentioning

confidence: 99%

Untitled

Prasanthi¹

2017

AJP

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Aim: The present study aimed at the development of valsartan floating tablets (VFTs) using Ocimum basilicum mucilage (OBM) and hydroxypropyl methylcellulose (HPMC) K100M by applying response surface methodologybased 3 2 factorial design. Materials and Methods: OBM (A) and HPMC K100M (B) were selected as independent factors, and swelling index (Y 1 ) and time taken for 90% drug release (Y 2 ) were as responses. Experimentally designed 9 runs assessed for Y 1 and Y 2 , and analysis of variance (ANOVA) was applied (P < 0.05) to define significant terms. Multicriterion decision approach anticipated optimized formulation VFT was developed and evaluated for physicochemical parameters such as weight variation, hardness, friability, thickness, and drug content. In vitro drug release and buoyancy studies, in vivo buoyancy studies, and Fourier transform infrared (FTIR) studies were carried out along with the validation of experimental design. Results and Discussion: Synergistic effect between polymers was observed in experimental runs, and ANOVA indicated a significant effect of A and B on Y 1 and Y 2 . Physicochemical parameters as well as floating lag time and total floating time of VFT were within the limits. FTIR studies unveiled drug and polymer compatibility. In vitro drug release studies demonstrated a good fit in zero-order and super Case-II transport drug release mechanism. Experimental values of VFT exhibited good agreement with predicted values generated by the software. In vivo buoyancy study in rabbit confirmed floatability of the VFT for 12 h. Conclusion: The present investigation concluded that statistically optimized VFT with OBM and HPMC K100M as rate retarding polymers exploiting as a promising formulation for gastric delivery of valsartan for longer periods.

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Preparation and In Vitro/In Vivo Evaluation of the Buccal Bioadhesive Properties of Slow-Release Tablets Containing Miconazole Nitrate

Cited by 53 publications

References 22 publications

Formulation and Evaluation of Swellable and Floating Gastroretentive Ciprofloxacin Hydrochloride Tablets

Formulation and Evaluation of Swellable and Floating Gastroretentive Ciprofloxacin Hydrochloride Tablets

In Vitro and in Vivo Evaluation of Buccal Bioadhesive Films Containing Salbutamol Sulphate

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