Preparation and optimization of chitosan-gelatin films for sustained delivery of lupeol for wound healing

Patel, Satish; Srivastava, Shikha; Singh, Manju Rawat; Singh, Deependra

doi:10.1016/j.ijbiomac.2017.10.056

Cited by 130 publications

(70 citation statements)

References 39 publications

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“…As shown in Figure , the spectra of both the unmodified and the GA‐modified gelatin samples showed similar feature bands at 3,400 cm –1 (Amide A band, due to the stretching vibrations of N–H bond or O–H bond), 1,640 cm –1 (Amide Ⅰ band, due to the stretching vibrations of C=O or C=N), and 1,530 cm –1 (Amide Ⅱ band, due to the bending vibrations of N–H or the stretching vibrations of C–N) (Liu et al, ). The GA‐modified gelatin has broad peak at Amide A bond indicating stretching vibration due to the increase of the number of O–H groups (Patel, Srivastava, Singh, & Singh, ). The Amide Ⅰ bound was centered at the same wavenumber (1646 cm –1 ) for both the unmodified and GA‐modified gelatin samples, suggesting that the carboxyl group of gelatin may be not involved in the crosslinking reaction with GA (Farris, Song, & Huang, ).…”

Section: Resultsmentioning

confidence: 99%

Controlled release of methylene blue from glutaraldehyde‐modified gelatin

Zhu

Zhang

et al. 2019

J Food Biochem

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Gelatin has been identified as a valuable material for controlled release of food ingredients because of its highly ramified three‐dimensional network. In the present work, gelatin was further modified with glutaraldehyde (GA) and prepared as microspheres to further improve its control to release of food ingredients. Features (i.e., chemical structures, thermal properties, network structures, and methylene blue (MB) release kinetics) of both the unmodified and GA‐modified gelatin microspheres were investigated. Results showed that the application of GA enhanced the formation of intramolecular and/or intermolecular crosslinking of gelatin and improved its thermal stability. Besides, the release efficiency of MB from the GA‐modified gelatin was less affected by temperature and pH value compared to the unmodified gelatin. Kinetics analysis proved that the release of MB from gelatin followed the first‐order kinetics. Both the release constant (k) of MB and the diffusion coefficient (Da) of GA‐modified gelatin were significantly lower than those of the unmodified gelatin. Practical applications Gelatin is a valuable material for the release control of food ingredients (e.g., oils, vitamins, antioxidants, and flavor compounds) attributes to its highly ramified three‐dimensional network. However, the low mechanical strength of gelatin makes it susceptible to many environmental factors and has restricted its application. In the present work, gelatin was modified by glutaraldehyde (GA). The chemical structure, thermal properties, network structure, and methylene blue release kinetics of the GA‐modified gelatin microspheres were properly investigated. This research proved that GA‐modified gelatin could be a potential carrier for the release control of given food contents in food industry.

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Section: Resultsmentioning

confidence: 99%

Controlled release of methylene blue from glutaraldehyde‐modified gelatin

Zhu

Zhang

et al. 2019

J Food Biochem

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“…Meanwhile, cell culture experiments revealed that this biomaterial did not exhibit cytotoxic effect towards mouse fibroblasts (NIH/3T3 cell line). Importantly, wound dressings may be also modified with natural and/or synthetic compounds in order to improve their antioxidant, anti-inflammatory, and antibacterial properties [238,247]. For instance, Ajmal et al [247] fabricated electrospun gelatin/PCL wound dressing modified with ciprofloxacin hydrochloride (CH) and quercetin (Que).…”

Section: Hacat and Bj Cell Lines/ Micementioning

confidence: 99%

Proteins and Peptides as Important Modifiers of the Polymer Scaffolds for Tissue Engineering Applications—A Review

2020

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Polymer scaffolds constitute a very interesting strategy for tissue engineering. Even though they are generally non-toxic, in some cases, they may not provide suitable support for cell adhesion, proliferation, and differentiation, which decelerates tissue regeneration. To improve biological properties, scaffolds are frequently enriched with bioactive molecules, inter alia extracellular matrix proteins, adhesive peptides, growth factors, hormones, and cytokines. Although there are many papers describing synthesis and properties of polymer scaffolds enriched with proteins or peptides, few reviews comprehensively summarize these bioactive molecules. Thus, this review presents the current knowledge about the most important proteins and peptides used for modification of polymer scaffolds for tissue engineering. This paper also describes the influence of addition of proteins and peptides on physicochemical, mechanical, and biological properties of polymer scaffolds. Moreover, this article sums up the major applications of some biodegradable natural and synthetic polymer scaffolds modified with proteins and peptides, which have been developed within the past five years.

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“…In order to repair the disrupted skin function, the wound-healing process starts immediately after development of the wound. This is a complex process that involves a series of coordinated events including homeostasis, inflammation, proliferation, remodeling, and scar maturation [3][4][5][6]. The wound-healing process may be further complicated by various factors such as diabetes mellitus, bacterial contamination, poor wound care, and patient lifestyle [7,8].…”

Section: Introductionmentioning

confidence: 99%

Development and Characterization of Hemicellulose-Based Films for Antibacterial Wound-Dressing Application

et al. 2020

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Hemicelluloses are biopolymers with versatile properties for biomedical applications. Herein, hemicellulose (arabinoxylan)-based antibacterial film dressings were prepared and characterized. Arabinoxylan was isolated from psyllium husk. Blank and gentamicin-loaded films were prepared by the solvent cast method using glycerol as the plasticizer. The appropriate composition of the films was obtained by varying the amounts of arabinoxylan, glycerol, and gentamicin. The films were found to be transparent, smooth, bubble-free, flexible, and easily peelable with 2% to 3% arabinoxylan. They had uniform thickness and swelled up to 60% of their initial size. The mechanical properties and water vapor transmission rate through the films were found to be suitable for wound-dressing application. Fourier transform infrared spectroscopy (FTIR) analysis confirmed drug–film compatibility. In an in vitro release study, more than 85% of the gentamicin was released from the films in 12 h. The antibacterial activities of the gentamicin-loaded films were found to be close to the standard gentamicin solution. The films were found to be cytocompatible in cell viability assay. These results suggested that hemicellulose-based films are promising materials for the dressing of infected wounds.

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Preparation and optimization of chitosan-gelatin films for sustained delivery of lupeol for wound healing

Cited by 130 publications

References 39 publications

Controlled release of methylene blue from glutaraldehyde‐modified gelatin

Controlled release of methylene blue from glutaraldehyde‐modified gelatin

Proteins and Peptides as Important Modifiers of the Polymer Scaffolds for Tissue Engineering Applications—A Review

Development and Characterization of Hemicellulose-Based Films for Antibacterial Wound-Dressing Application

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