Preparation and optimization of Pickering emulsion stabilized by chitosan-tripolyphosphate nanoparticles for curcumin encapsulation

Shah, Bakht Ramin; Li, Yan; Jin, Weiping; An, Yaping; He, Lei; Li, Zhenshun; Xu, Wei

doi:10.1016/j.foodhyd.2015.07.015

Cited by 291 publications

(116 citation statements)

References 33 publications

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“…The in vitro release study of MIF from MCNs was performed in PBS buffer solutions at pH 7.4 or pH 2.5 to simulate the different pH conditions of the gastrointestinal system [31–32]. To enhance the solubility of MIF, 1% of ethanol was added to the incubation medium.…”

Section: Resultsmentioning

confidence: 99%

Chitosan-based nanoparticles for improved anticancer efficacy and bioavailability of mifepristone

Zhang¹,

Wu²,

Li³

et al. 2016

Beilstein J. Nanotechnol.

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In addition to its well-known abortifacient effect, mifepristone (MIF) has been used as an anticancer drug for various cancers in many studies with an in-depth understanding of the mechanism of action. However, application of MIF is limited by its poor water solubility and low oral bioavailability. In this work, we developed a drug delivery system based on chitosan nanoparticles (CNs) to improve its bioavailability and anticancer activity. The MIF-loaded chitosan nanoparticles (MCNs) were prepared by convenient ionic gelation techniques between chitosan (Cs) and tripolyphosphate (TPP). The preparation conditions, including Cs concentration, TPP concentration, Cs/MIF mass ratio, and pH value of the TPP solution, were optimized to gain better encapsulation efficiency (EE) and drug loading capacity (DL). MCNs prepared with the optimum conditions resulted in spherical particles with an average size of 200 nm. FTIR and XRD spectra verified that MIF was successfully encapsulated in CNs. The EE and DL of MCNs determined by HPLC were 86.6% and 43.3%, respectively. The in vitro release kinetics demonstrated that MIF was released from CNs in a sustained-release manner. Compared with free MIF, MCNs demonstrated increased anticancer activity in several cancer cell lines. Pharmacokinetic studies in male rats that were orally administered MCNs showed a 3.2-fold increase in the area under the curve from 0 to 24 h compared with free MIF. These results demonstrated that MCNs could be developed as a potential delivery system for MIF to improve its anticancer activity and bioavailability.

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Section: Resultsmentioning

confidence: 99%

Chitosan-based nanoparticles for improved anticancer efficacy and bioavailability of mifepristone

Zhang¹,

Wu²,

Li³

et al. 2016

Beilstein J. Nanotechnol.

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“…Moreover, it is a highly hydrophobic molecule with a low water-solubility and poor oral bioavailability. For these reasons, vitamin D is often encapsulated within edible colloidal delivery systems (CDS), such as nanoparticles or microparticles assembled from food-grade biopolymers (Abbasi, Emam-djomeh, Mousavi, & Davoodi, 2014;Lin, Wang, Yang, Guo, & Wang, 2016;Teng, Luo, & Wang, 2013) or lipids (Mohammadi, Ghanbarzadeh, & Hamishehkar, 2014;Ozturk, Argin, Ozilgen, & McClements, 2015a;Shah et al, 2016;Winuprasith et al, 2018). Encapsulation in CDS can increase both the stability and bioavailability of vitamins and other bioactive molecules (Luo, Teng, & Wang, 2012).…”

Section: Introductionmentioning

confidence: 99%

Encapsulation of Vitamin D₃ in Pickering Emulsion Stabilized by Nanofibrillated Mangosteen Cellulose: Effect of Environmental Stresses

Mitbumrung

Suphantharika

McClements

et al. 2019

Journal of Food Science

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Vitamin D3 was encapsulated in 10% wt soybean oil‐in‐water (O/W) Pickering emulsions stabilized by either nanofibrillated cellulose (NFC) or whey protein isolate (WPI) at 0.3%, 0.5%, and 0.7% w/w. The vitamin D3‐enriched emulsions were tested for their stability against temperature (30 °C to 90 °C), pH (2 to 8), and ionic strength (0 to 500 mM NaCl). The mean particle diameter (d32), ζ‐potential, and creaming stability of the oil droplets in the emulsions were measured, as well as their vitamin D3 encapsulation efficiency (EE). After preparation, the oil droplet size (d32) of the emulsions stabilized by NFC increased with increasing emulsifier concentration, whereas the droplet size of emulsions stabilized by WPI decreased. NFC provided good stability to the emulsions through a combination of steric and electrostatic repulsion. The EE of vitamin D3 increased with increasing emulsifier concentration. Heating or ionic strength did not significantly (P < 0.05) affect the emulsions properties and EE. On the other hand, the NFC‐stabilized emulsions were sensitive to highly acidic conditions (pH 2), with an increase in particle size and decrease in EE. The WPI‐stabilized emulsions aggregated around the isoelectric point of the adsorbed proteins (pI ≈ 4.8). Increasing NFC or WPI concentration improved the stability and EE of the emulsions against environmental stresses. NFC‐stabilized emulsions had good long‐term stability. The results show that NFC can be used as an effective emulsifier for creating vitamin‐enriched emulsions with good stability. Practical Application This study can be used to develop more effective encapsulation technologies for fat‐soluble vitamins in emulsion‐based food products. Encapsulation using nanofibrillated cellulose effectively protected the encapsulated vitamins against environmental stresses which occur in industrial food production (such as pH changes, salt addition, and thermal processing). Moreover, nanofibrillated cellulose extracted from mangosteen rind is a nature‐derived emulsifier that is environmental friendly.

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“…This protection was further improved by introducing curcumin, known for its antioxidant properties, in the particles. This property could be useful to protect fragile encapsulated API.Shah et al[202] successfully encapsulated curcumin in the oil droplets of emulsions stabilized by chitosan nanoparticles crosslinked with tripolyphosphate. Better protection of curcumin against degradation during storage and slower release rate were obtained with such Pickering emulsions than with classical emulsions.…”

mentioning

confidence: 99%

Pickering emulsions: Preparation processes, key parameters governing their properties and potential for pharmaceutical applications

Albert

Beladjine

Tsapis

et al. 2019

Journal of Controlled Release

330

243

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Preparation and optimization of Pickering emulsion stabilized by chitosan-tripolyphosphate nanoparticles for curcumin encapsulation

Cited by 291 publications

References 33 publications

Chitosan-based nanoparticles for improved anticancer efficacy and bioavailability of mifepristone

Chitosan-based nanoparticles for improved anticancer efficacy and bioavailability of mifepristone

Encapsulation of Vitamin D₃ in Pickering Emulsion Stabilized by Nanofibrillated Mangosteen Cellulose: Effect of Environmental Stresses

Pickering emulsions: Preparation processes, key parameters governing their properties and potential for pharmaceutical applications

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Preparation and optimization of Pickering emulsion stabilized by chitosan-tripolyphosphate nanoparticles for curcumin encapsulation

Cited by 291 publications

References 33 publications

Chitosan-based nanoparticles for improved anticancer efficacy and bioavailability of mifepristone

Chitosan-based nanoparticles for improved anticancer efficacy and bioavailability of mifepristone

Encapsulation of Vitamin D3 in Pickering Emulsion Stabilized by Nanofibrillated Mangosteen Cellulose: Effect of Environmental Stresses

Pickering emulsions: Preparation processes, key parameters governing their properties and potential for pharmaceutical applications

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Encapsulation of Vitamin D₃ in Pickering Emulsion Stabilized by Nanofibrillated Mangosteen Cellulose: Effect of Environmental Stresses