Preparation and Properties of Copolyanhydrides Based on 2-Hexadecylsuccinic Acid and Sebacic Acid

Abstract

Poly(2-hexadecylsuccinic acid-sebacic acid) (P(HSA-SA)) copolymers have been prepared by melt polycondensation. The copolymers were characterized by FT-IR, 1 HNMR, gel permeation chromatography (GPC), differential scanning calorimetry (DSC) and thermal gravimetric analysis (TGA). In vitro studies showed that all our prepared copolymers are degradable in phosphate buffer at 37 °C. The release profiles of hydrophilic model drug, ciprofloxcin hydrochloride, from the copolymers, follow first order release kinetics. All the preliminary results suggested that the copolymer might be potentially used as drug delivery devices.

Polyanhydrides

“…Succinic acid derivatives were utilized more widely to synthesize unsaturated and functional polymers. Copolymers of 2 -hexadecylsuccinic acid and SA were prepared using usual melt -condensation method and demonstrated to be potential drug carriers for localized drug delivery [58] . In another study, hydroxylgroup functional polylactones were prepared and converted to acid -terminated polyesters in a reaction with a series of alkenylsuccinic anhydrides containing 8, 12, or 18 carbons in their alkenyl chains [55] .…”