Preparation and Properties of Iron Nanoparticle-Based Macroporous Scaffolds for Biodegradable Implants

Abstract

Fe-based scaffolds are of particular interest in the technology of biodegradable implants due to their high mechanical properties and biocompatibility. In the present work, using an electroexplosive Fe nanopowder and NaCl particles 100–200 µm in size as a porogen, scaffolds with a porosity of about 70 ± 0.8% were obtained. The effect of the sintering temperature on the structure, composition, and mechanical characteristics of the scaffolds was considered. The optimum parameters of the sintering process were determined, allowing us to obtain samples characterized by plastic deformation and a yield strength of up to 16.2 MPa. The degradation of the scaffolds sintered at 1000 and 1100 °C in 0.9 wt.% NaCl solution for 28 days resulted in a decrease in their strength by 23% and 17%, respectively.

Comparison of the differentiation of ovine fetal bone-marrow mesenchymal stem cells towards osteocytes on chitosan/alginate/CuO-NPs and chitosan/alginate/FeO-NPs scaffolds

“…Metals and metal composites are highly promising materials for bone remodeling due to their high plasticity and mechanical strength 73 . Fe is a component of many enzymes and proteins necessary for metabolic processes 74 . Copper is an essential trace element in the bone matrix, enhancing the angiogenic and osteogenic properties of bone tissue engineering scaffolds 75 .…”

Two-Photon-Excited FLIM of NAD(P)H and FAD—Metabolic Activity of Fibroblasts for the Diagnostics of Osteoimplant Survival

“…The survival rate of implants depends on factors related to the surgical and clinical features of the installation of osteoimplants, but one of the main ones is the composition and properties of the material from which they are made [4]. Non-toxicity and biocompatibility are important characteristics of the materials used for the manufacture of osteoimplants, but, recently, special attention has been paid to the development of materials with bioresorption [5,6]. This is because, over time, the damaged area of bone tissue is capable of self-healing, and only temporal support is needed to preserve the integral structure of the bone.…”