Preparation and properties of nano silica-based bioactive glass/apatite/sodium alginate composite hydrogel

Guan, Ye-xiao; Mao, Yanrui; Liao, Jianguo

doi:10.1016/j.jmbbm.2022.105515

Cited by 4 publications

(2 citation statements)

References 41 publications

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“…The findings are in line with previous studies showing that the incorporation of BG MPs into the biopolymer composition increases scaffold bioactivity. [54] As a result, the test allowed the determination of the osteogenic bioactivity of the developed DBM and DBM+BG composite scaffolds. [55]…”

Section: Bioactivity Assessment Based On Mineralizationmentioning

confidence: 99%

Decellularized Bone Matrix/45S5 Bioactive Glass Biocomposite Hydrogel‐Based Constructs with Angiogenic and Osteogenic Properties: Ex Ovo and Ex Vivo Evaluations

Aytekin,

Vurat,

Elçin

et al. 2023

Macromolecular Bioscience

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Decellularized extracellular matrix is often used to create an in vivo‐like environment that supports cell growth and proliferation, as it reflects the micro/macrostructure and molecular composition of tissues. On the other hand, bioactive glasses (BG) are surface‐reactive glass‐ceramics that can convert to hydroxyapatite in vivo and promote new bone formation. This study is designed to evaluate the key properties of a novel angiogenic and osteogenic biocomposite graft made of bovine decellularized bone matrix (DBM) hydrogel and 45S5 BG microparticles (10 and 20 wt%) to combine the existing superior properties of both biomaterial classes. Morphological, physicochemical, mechanical, and thermal characterizations of DBM and DBM/BG composite hydrogels are performed. Their in vitro biocompatibility is confirmed by cytotoxicity and hemocompatibility analyses. Ex vivo chick embryo aortic arch and ex ovo chick chorioallantoic membrane (CAM) assays reveal that the present pro‐angiogenic property of DBM hydrogels is enhanced by the incorporation of BG. Histochemical stainings (Alcian blue and Alizarin red) and digital image analysis of ossification on hind limbs of embryos used in the CAM model reveal the osteogenic potential of biomaterials. The findings support the notion that the developed DBM/BG composite hydrogel constructs have the potential to be a suitable graft for bone repair.

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Section: Bioactivity Assessment Based On Mineralizationmentioning

confidence: 99%

Decellularized Bone Matrix/45S5 Bioactive Glass Biocomposite Hydrogel‐Based Constructs with Angiogenic and Osteogenic Properties: Ex Ovo and Ex Vivo Evaluations

Aytekin,

Vurat,

Elçin

et al. 2023

Macromolecular Bioscience

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“…A good dressing material with antibacterial characteristics is necessary in such a situation. [1][2][3][4][5][6] Dressings are crucial in preventing infection and boosting growth factors for faster healing. 7,8 Traditional wound dressings are primarily dry and challenging to apply, and they cannot heal patients.…”

Section: Introductionmentioning

confidence: 99%

Fabrication, Properties, and Stability of Oregano Essential Oil and Sodium Alginate-Based Wound-Healing Hydrogels

Iqbal,

Ashraf,

Nazir

et al. 2023

Dose-Response

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The wound dressings fabricated by polymers and oregano essential oil (OEO) can be very effective as a hydrogel. The current study has been focused on fabricating the hydrogel membranes of oregano oil encapsulated as an antibacterial agent into sodium alginate (SA) solution by solvent casting method and then evaluated the antibacterial, antioxidant activity, and physicochemical performance of SA/OEO-based polymeric membranes. The polymeric interactions, surface morphology, water absorption capability, thermal stability, and encapsulation efficiency were investigated by FT-IR, SEM, swelling ratio, DSC, and encapsulation efficiency. The percentage encapsulation efficiency of essential oil was 40.5%. FTIR validated the presence of molecular interaction between individual components. SEM images showed a rough and porous appearance for hydrogel membranes. Moreover, DSC showed that the fabricated membranes were thermally stable. The inclusion of more content OEO decreased swelling ratios. The antioxidant test was carried out by DPPH assay and antibacterial test through disc diffusion method against microbes. The results revealed that membranes containing the highest content of OEO had more excellent antioxidant and antibacterial efficacy. Therefore, the polymeric membranes of sodium alginate loaded with oregano essential oil can be employed as an effective wound-healing candidate.

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From micropores to mechanical strength: Fabrication and characterization of edible corn starch-sodium alginate double network hydrogels with Ca2+ cross-linking

Su,

Li,

Wang

2025

Food Chemistry

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Preparation and properties of nano silica-based bioactive glass/apatite/sodium alginate composite hydrogel

Cited by 4 publications

References 41 publications

Decellularized Bone Matrix/45S5 Bioactive Glass Biocomposite Hydrogel‐Based Constructs with Angiogenic and Osteogenic Properties: Ex Ovo and Ex Vivo Evaluations

Decellularized Bone Matrix/45S5 Bioactive Glass Biocomposite Hydrogel‐Based Constructs with Angiogenic and Osteogenic Properties: Ex Ovo and Ex Vivo Evaluations

Fabrication, Properties, and Stability of Oregano Essential Oil and Sodium Alginate-Based Wound-Healing Hydrogels

From micropores to mechanical strength: Fabrication and characterization of edible corn starch-sodium alginate double network hydrogels with Ca2+ cross-linking

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