Preparation and Properties of Narrowly Dispersed Polyurethane Nanocapsules Containing Essential Oil via Phase Inversion Emulsification

Cui, Guangwen; Wang, Jian Ping; Wang, Xuechen; Wei, Li

doi:10.1021/acs.jafc.8b02406

Cited by 20 publications

(9 citation statements)

References 41 publications

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“…Polyurethane nanocapsules have been used extensively for self-healing dental resins and bone cements 27 , essential oils 47 and enzymatically triggered drug delivery systems [48][49] . The last nanocapsules involve the incorporation of peptides into the polyurethane synthesis that are enzymatically degraded to trigger release in particular biological compartments.…”

Section: Acriflavine Long Term Release and On Demand Deliverymentioning

confidence: 99%

On-Demand and Long-Term Drug Delivery from Degradable Nanocapsules

Menikheim¹,

Leckron²,

Bernstein

et al. 2020

ACS Appl. Bio Mater.

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While there are a number of nanomaterials that can lead to on demand drug delivery or longterm delivery, there are limited nanotechnologies that are stable for long times, deliver sustained amounts of drugs, and achieve repeated, on demand delivery. We have developed a system based on polyurethane nanocapsules as a platform for long-term and on demand delivery. We synthesized nanocapsules encapsulating either a model drug, fluorescein, or a clinically relevant drug, acriflavine, a HIF-1alpha inhibitor. The nanocapsules were ~250 nm in diameter as measured by DLS and confirmed via SEM, and the molecules were localized in the walls of the nanocapsules as determined by confocal microscopy. Release studies were performed at 37 C in PBS, and both the fluorescein and acriflavine were delivered over several weeks. At the end of the release, no pellet was detectable upon centrifugation of the nanocapsules confirming degradation of the polyurethane shells. The same particles released a fraction of their payload upon the application of either an ultrasonic probe or a clinical grade, ultrasound imaging system used for assessing the retina. The amount of drug released could be tailored by the energy applied to the nanocapsules. One of the most exciting findings beyond being able to tailor how much was released based on the energy applied and the time it was applied was that these nanocapsules could be triggered to release multiple times with at least 10 separate release events triggered for each formulation. Being able to tailor the on-demand release over multiple cycles has the potential to fundamentally change how we can approach delivery of drugs for a variety of applications.

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Section: Acriflavine Long Term Release and On Demand Deliverymentioning

confidence: 99%

On-Demand and Long-Term Drug Delivery from Degradable Nanocapsules

Menikheim¹,

Leckron²,

Bernstein

et al. 2020

ACS Appl. Bio Mater.

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“…7 b). It can be seen from the figure that the thermogravimetric diagram of PS before and after curing with VO was consistent, indicating that the PS had no effect on the physical and chemical properties of the VO 20 .…”

Section: Resultsmentioning

confidence: 79%

Study of the volatilization rules of volatile oil and the sustained-release effect of volatile oil solidified by porous starch

Ren

Ke²,

Huang

et al. 2022

Sci Rep

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Volatile oil from traditional Chinese medicine has various biological activities and has pharmacological activities in the central nervous system, digestive system, cardiovascular system, respiratory system, etc. These oils are widely used in clinical practice. However, the development of their clinical applications is restricted due to the disadvantages of volatile oils, such as high stimulation, high volatility and poor stability. To improve the stability of a volatile oil in the preparation process, its volatilization and stable release must be controlled. In this paper, porous starch was used as a solid carrier material, and liquid volatile oil was solidified by physical adsorption. GC–MS was used to determine the chemical constituents of the volatile oil, solidified powder and tablets, and the volatilization rules of 34 chemical constituents were analysed statistically. The solidified volatile oil/porous starch powder was characterized by XRD, TGA and DSC, and the VOCs of the volatile oil before and after solidification were analysed by portable GC–MS. Finally, the stable release of the volatile oil could be optimized by changing the porous starch ratio in the formulation. Volatilization was shown to be closely related to the peak retention time and chemical composition, which was consistent with the theory of flavour. The physical properties and chemical composition of the volatile oil did not change after curing, indicating that the adsorption of the volatile oil by porous starch was physical adsorption. In this paper, the porous starch-solidified volatile oil had a slow-release effect, and the production process is simple, easy to operate, and has high application value.

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“…Encapsulation involves enclosing EO droplets within a protective material, which can originate from synthetic or natural sources. [19] Encapsulation techniques includs spray drying, [29,30] coacervation, [31][32][33] emulsification, [34][35][36] and the use of lipid carriers. [37][38][39] Table 3 presents examples of specific active ingredients and recommends the most suitable encapsulation technique for each of them.…”

Section: Systems Used In the Encapsulationmentioning

confidence: 99%

Innovative Encapsulation Strategies for Food, Industrial, and Pharmaceutical Applications

Aanniz,

El Omari,

Elouafy

et al. 2024

Chemistry & Biodiversity

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Encapsulation has emerged as a vitally important tool for protecting the integrity of critical chemicals and improving the delivery mechanisms of natural/synthetic drugs, enabling the controlled release of ingredients and the maintenance of their chemical, physical, and biological properties. It is well known that essential oils (EOs) provide a valuable alternative for food preservation, as they help reducing the deterioration of foodstuffs as well as the proliferation of pathogens. Nevertheless, EOs are highly volatile and lipophilic, rendering them insoluble in aqueous systems. In addition, their secondary metabolites are extremely susceptible to environmental factors such as humidity, temperature, light, and oxygen. Therefore, encapsulation of EOs is an innovative option not only for preserving these substances but also for promoting their stability, controlling their release, and optimizing their efficiency and bioavailability. In this sense, this review aimed to describe current techniques and approaches used to incorporate natural hydrophobic compounds, covering EOs. It also examines whether encapsulation technology can be used efficiently in drug discovery and development. Studies have shown that microencapsulation, the use of nanoparticle, and liposomal are the most effective techniques for encapsulating EOs. Other encapsulation systems included spray drying, coacervation, and emulsification.

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Preparation and Properties of Narrowly Dispersed Polyurethane Nanocapsules Containing Essential Oil via Phase Inversion Emulsification

Cited by 20 publications

References 41 publications

On-Demand and Long-Term Drug Delivery from Degradable Nanocapsules

On-Demand and Long-Term Drug Delivery from Degradable Nanocapsules

Study of the volatilization rules of volatile oil and the sustained-release effect of volatile oil solidified by porous starch

Innovative Encapsulation Strategies for Food, Industrial, and Pharmaceutical Applications

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