Preparation and properties of nitrate-deficient gadolinium nitrate solutions

Baumann, Elizabeth W.

doi:10.1016/0022-1902(80)80144-8

Cited by 7 publications

(2 citation statements)

References 6 publications

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“…The main problem in the synthesis of rare earth doped ceria colloids arises from very high differences in the solubility of ceria and rare earth hydroxides. In particular, the solubility of gadolinium hydroxide is more than ten orders of magnitude higher than that of ceria (p K sp (Gd(OH) 3 ) = 27 [ 43 ], p K sp (Ce(OH) 4 ) = 42 [ 44 ], p K sp (CeO 2 ) = 59 [ 12 ]). In this regard, even the sequence of the addition of chemicals into the reaction mixture is meaningful.…”

Section: Resultsmentioning

confidence: 99%

Heavily Gd-Doped Non-Toxic Cerium Oxide Nanoparticles for MRI Labelling of Stem Cells

et al. 2023

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Recently, human mesenchymal stem cells (hMSc) have attracted a great deal of attention as potential therapeutic agents in the treatment of socially significant diseases. Despite substantial advances in stem-cell therapy, the biological mechanisms of hMSc action after transplantation remain unclear. The use of magnetic resonance imaging (MRI) as a non-invasive method for tracking stem cells in the body is very important for analysing their distribution in tissues and organs, as well as for ensuring control of their lifetime after injection. Herein, detailed experimental data are reported on the biocompatibility towards hMSc of heavily gadolinium-doped cerium oxide nanoparticles (Ce0.8Gd0.2O2−х) synthesised using two synthetic protocols. The relaxivity of the nanoparticles was measured in a magnetic field range from 1 mT to 16.4 T. The relaxivity values (r1 = 11 ± 1.2 mM−1 s−1 and r1 = 7 ± 1.2 mM−1 s−1 in magnetic fields typical of 1.5 and 3 T MRI scanners, respectively) are considerably higher than those of the commercial Omniscan MRI contrast agent. The low toxicity of gadolinium-doped ceria nanoparticles to hMSc enables their use as an effective theranostic tool with improved MRI-contrasting properties.

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Section: Resultsmentioning

confidence: 99%

Heavily Gd-Doped Non-Toxic Cerium Oxide Nanoparticles for MRI Labelling of Stem Cells

et al. 2023

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“…Throughout this period, a heavy water solution of gadolinium nitrate was utilized in a standby emergency shutdown system that could inject this chemical into the reactor moderator coolant water. The chemical was used for this purpose because the high neutron absorption cross sections of some gadolinium isotopes make gadolinium salts such as GdNO 3 effective in controlling nuclear activity in aqueous systems (Baumann, 1980;Gilbert et al, 1985, Rodenas et al 1990). Currently, there is an inventory of approximately 181 55-gallon drums (37,680 liters overall) of this degraded heavy water containing gadolinium nitrate.…”

Section: Introduction and Description Of Problemmentioning

confidence: 99%