Preparation and properties of osmoglobins. Oxidation-reduction catalytic activity of ruthenated osmoglobin

Che, Chi‐Ming; Chiang, Hsin‐Ju; Margalit, Ruth; Gray, Harry B.

doi:10.1007/bf00765353

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Cited by 5 publications

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“…Isoelectronic metals from the same group, like ruthenium or osmium, were only used for the substitution of iron in Mb [11][12][13]. Here, ruthenium (II) substituted Mb (Ru II Mb) binds carbon monoxide and can be oxidized to Ru III Mb by molecular oxygen [11].…”

Section: Introductionmentioning

confidence: 99%

Direct electrochemistry and spectroelectrochemistry of osmium substituted horseradish peroxidase

Loew

Wollenberger

Scheller

et al. 2009

Bioelectrochemistry

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Section: Introductionmentioning

confidence: 99%

Direct electrochemistry and spectroelectrochemistry of osmium substituted horseradish peroxidase

Loew

Wollenberger

Scheller

et al. 2009

Bioelectrochemistry

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A Designed Functional Metalloenzyme that Reduces O₂ to H₂O with Over One Thousand Turnovers

et al. 2012

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Der gezielte Entwurf funktioneller Enzyme mit hohem Turnover, insbesondere solcher mit komplexem aktivem Zentrum wie respiratorischer Oxidasen, ist eine Herausforderung. Durch Einführung zweier His‐ und eines Tyr‐Restes in Myoglobin wurden Enzyme erhalten, die O2 in mehr als 1000 Turnovers und mit minimaler Freisetzung reaktiver Sauerstoffspezies zu H2O reduzieren (rote Linie im Schema). Die Platzierung des Tyr‐Restes ist entscheidend für die Aktivität.

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A Designed Functional Metalloenzyme that Reduces O₂ to H₂O with Over One Thousand Turnovers

et al. 2012

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Summary Rational design of functional enzymes with high turnovers is a significant challenge, especially those with complex active site and difficult reactions, such as in respiratory oxidases. Introducing 2 His and 1 Tyr into myoglobin resulted in designed enzymes that reduce O2 to H2O with > 1000 turnovers and minimal release of reactive oxygen species. This also showed that presence and positioning of Tyr, not Cu, are critical for activity.

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Preparation and properties of osmoglobins. Oxidation-reduction catalytic activity of ruthenated osmoglobin

Cited by 5 publications

References 19 publications

Direct electrochemistry and spectroelectrochemistry of osmium substituted horseradish peroxidase

Direct electrochemistry and spectroelectrochemistry of osmium substituted horseradish peroxidase

A Designed Functional Metalloenzyme that Reduces O₂ to H₂O with Over One Thousand Turnovers

A Designed Functional Metalloenzyme that Reduces O₂ to H₂O with Over One Thousand Turnovers

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Preparation and properties of osmoglobins. Oxidation-reduction catalytic activity of ruthenated osmoglobin

Cited by 5 publications

References 19 publications

Direct electrochemistry and spectroelectrochemistry of osmium substituted horseradish peroxidase

Direct electrochemistry and spectroelectrochemistry of osmium substituted horseradish peroxidase

A Designed Functional Metalloenzyme that Reduces O2 to H2O with Over One Thousand Turnovers

A Designed Functional Metalloenzyme that Reduces O2 to H2O with Over One Thousand Turnovers

Contact Info

Product

Resources

About

A Designed Functional Metalloenzyme that Reduces O₂ to H₂O with Over One Thousand Turnovers

A Designed Functional Metalloenzyme that Reduces O₂ to H₂O with Over One Thousand Turnovers