Preparation and Properties of Poly(amidoamine) Dendrimer/Quaternary Ammonium Chitosan Hydrogels

He, Guowei; Kong, Yahui; Zheng, Hua; Ke, Wanwan; Chen, Xiang; Yin, Yi

doi:10.1007/s11595-018-1886-9

Cited by 6 publications

(7 citation statements)

References 34 publications

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“…The chemical functionalization of chitosan with biocompatible polymeric structures, such as grafting copolymerization or coupling with biodegradable dendrimers and cyclodextrins, has shown to improve relevant features for its use in hydrogel formulations [13]. Dendrimers, highly branched globular macromolecular structures with nanometer-scale dimensions, possess a typical tree-like architecture able to influence the chemical and physical properties of chitosan/dendrimer hybrids, especially at high molecular weights, thus offering several possibilities in biomedical applications [14][15][16]. Among the different types of synthetic dendrimers, the poly(amidoamine) (PAMAM) dendrimers, which consist of alkyl-diamine cores, represent the most common class of biodegradable dendrimers and have been investigated for the targeted delivery of drugs and genes as well as for the development of co-delivery systems [17].…”

Section: Introductionmentioning

confidence: 99%

Chitosan/PAMAM/Hydroxyapatite Engineered Drug Release Hydrogels with Tunable Rheological Properties

et al. 2020

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In this paper, a new formulation of biodegradable and bioresorbable chitosan-based hydrogel for controlled drug release was investigated. A chitosan–dendrimer–hydroxyapatite hydrogel, obtained by covalently grafting chitosan powder with an hyperbranched PAMAM dendrimer followed by in-situ precipitation of hydroxyapatite and gelification, was synthesized and characterized by FTIR, NMR, TGA, XRD and rheological studies. The hydrogels have been also doped with an anti-inflammatory drug (ketoprofen) in order to investigate their drug release properties. Chemical and chemical-physical characterizations confirmed the successful covalent functionalization of chitosan with PAMAM and the synthesis of nanostructured hydroxyapatite. The developed hydrogel made it possible to obtain an innovative system with tunable rheological and drug-releasing properties relative to the well-known formulation containing chitosan and hydroxyapatite powder. The developed hydrogel showed different rheological and drug-releasing properties of chitosan matrix mixed with hydroxyapatite as a function of dendrimer molecular weight; therefore, the chitosan–dendrimer–hydroxyapatite hydrogel can couple the well-known osteoconductive properties of hydroxyapatite with the drug-release behavior and good processability of chitosan–dendrimer hydrogels, opening new approaches in the field of tissue engineering based on biopolymeric scaffolds.

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Section: Introductionmentioning

confidence: 99%

Chitosan/PAMAM/Hydroxyapatite Engineered Drug Release Hydrogels with Tunable Rheological Properties

et al. 2020

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“…The FTIR spectrum shown in Figure a indicates the presence of functional groups in membrane which verifies the successful blending of CMC and PAMAM. The peak at 1658 cm –1 is associated with the CO bond of PAMAM. , The peak from 3580 to 3100 corresponds to N–H and O–H stretching vibration of CMC and PAMAM, respectively. The broadness of the peak can be associated with the large number of N–H groups present in the membrane due to the addition of PAMAM.…”

Section: Resultsmentioning

confidence: 99%

“…The peak at 1658 cm −1 is associated with the CO bond of PAMAM. 46,47 The peak from 3580 to 3100 corresponds to N−H and O−H stretching vibration of CMC and PAMAM, respectively. The broadness of the peak can be associated with the large number of N−H groups present in the membrane due to the addition of PAMAM.…”

Section: Resultsmentioning

confidence: 99%

pH Responsive Carboxymethyl Chitosan/Poly(amidoamine) Molecular Gate Membrane for CO₂/N₂ Separation

Borgohain

Mandal

2019

ACS Appl. Mater. Interfaces

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Efficient carbon dioxide separation is an emerging field of interest in the era of energy scarcity and environmental calamity. The present study focuses on the versatile aspects of carboxymethyl chitosan and dendrimer in terms of CO2 separation. A comprehensive study has been accomplished to inspect the physicochemical properties of the prepared membrane. The mixed gas (CO2/N2) separation performances have been measured varying the temperature (60–110 °C) and sweep/feedwater flow ratio (0.33–3). The blend membrane containing 10 weight (wt.)% dendrimer presented highest CO2 permeance of ∼100 GPU and CO2/N2 selectivity ∼149 on maintenance of sweep/feedwater flow ratio 2.33 and 1.67, respectively, at an operating temperature of 90 °C. The remarkable performance displayed by the membrane has been explained with reference to the dendrimer molecular gate mechanism and the salting out effect offered by carboxymethyl chitosan matrix.

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“…Moreover, the GTMAC could be conjugated to Ch by reacting with the epoxide rings yielding a cationic GCh that could electrostatically bind to VC due to the presence of quaternary ammonium groups. Furthermore, GTMAC has been shown to possess better antimicrobial properties, which could preserve the nanocapsules and VC from degradation ( He et al., 2018 ). Henceforth, glycidyl trimethylammonium chloride (GTMAC) was conjugated to Ch to enhance the solubility, attachment and preserve the negatively charged VC.…”

Section: Introductionmentioning

confidence: 99%

Encapsulation and controlled release of vitamin C in modified cellulose nanocrystal/chitosan nanocapsules

Baek

Ramasamy

Willis

et al. 2021

Current Research in Food Science

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Vitamin C (VC), widely used in food, pharmaceutical and cosmetic products, is susceptible to degradation, and new formulations are necessary to maintain its stability. To address this challenge, VC encapsulation was achieved via electrostatic interaction with glycidyltrimethylammonium chloride (GTMAC)-chitosan (GCh) followed by cross-linking with phosphorylated-cellulose nanocrystals (PCNC) to form VC-GCh-PCNC nanocapsules. The particle size, surface charge, degradation, encapsulation efficiency, cumulative release, free-radical scavenging assay, and antibacterial test were quantified. Additionally, a simulated human gastrointestinal environment was used to assess the efficacy of the encapsulated VC under physiological conditions. Both VC loaded, GCh-PCNC, and GCh-Sodium tripolyphosphate (TPP) nanocapsules were spherical with a diameter of 450 ± 8 and 428 ± 6 nm respectively. VC-GCh-PCNC displayed a higher encapsulation efficiency of 90.3 ± 0.42% and a sustained release over 14 days. The release profiles were fitted to the first-order and Higuchi kinetic models with R 2 values greater than 0.95. VC-GCh-PCNC possessed broad-spectrum antibacterial activity with a minimum inhibition concentration (MIC) of 8–16 μg/mL. These results highlight that modified CNC-based nano-formulations can preserve, protect and control the release of active compounds with improved antioxidant and antibacterial properties for food and nutraceutical applications.

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Preparation and Properties of Poly(amidoamine) Dendrimer/Quaternary Ammonium Chitosan Hydrogels

Cited by 6 publications

References 34 publications

Chitosan/PAMAM/Hydroxyapatite Engineered Drug Release Hydrogels with Tunable Rheological Properties

Chitosan/PAMAM/Hydroxyapatite Engineered Drug Release Hydrogels with Tunable Rheological Properties

pH Responsive Carboxymethyl Chitosan/Poly(amidoamine) Molecular Gate Membrane for CO₂/N₂ Separation

Encapsulation and controlled release of vitamin C in modified cellulose nanocrystal/chitosan nanocapsules

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Preparation and Properties of Poly(amidoamine) Dendrimer/Quaternary Ammonium Chitosan Hydrogels

Cited by 6 publications

References 34 publications

Chitosan/PAMAM/Hydroxyapatite Engineered Drug Release Hydrogels with Tunable Rheological Properties

Chitosan/PAMAM/Hydroxyapatite Engineered Drug Release Hydrogels with Tunable Rheological Properties

pH Responsive Carboxymethyl Chitosan/Poly(amidoamine) Molecular Gate Membrane for CO2/N2 Separation

Encapsulation and controlled release of vitamin C in modified cellulose nanocrystal/chitosan nanocapsules

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Product

Resources

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pH Responsive Carboxymethyl Chitosan/Poly(amidoamine) Molecular Gate Membrane for CO₂/N₂ Separation