Preparation and Properties of Poly(lactide-co-glycolide) (PLGA)/ Nano-Hydroxyapatite (NHA) Scaffolds by Thermally Induced Phase Separation and Rabbit MSCs Culture on Scaffolds

Huang, Y.; Ren, Jie; Chen, C.; Ren, Tao; Zhou, Xihui

doi:10.1177/0885328207077632

Cited by 124 publications

(72 citation statements)

References 40 publications

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“…For example, adhesion, proliferation and differentiation of mesenchymal stem cells were studied on nano-sized HA/polyamide biocomposite scaffolds. The results indicated that such biocomposites exhibited a good biocompatibility and an extensive osteoconductivity with host bone in vitro and in vivo and proved that nano-sized HA/polyamide scaffolds had a potential to be used in orthopedic, reconstructive and maxillofacial surgery [664][665][666].…”

Section: Nanodimensional and Nanocrystalline Calcium Orthophosphates mentioning

confidence: 86%

Nanodimensional and Nanocrystalline Calcium Orthophosphates

Dorozhkin¹

2012

AJBE

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Nano-sized particles and crystals play an important role in the formation of calcified tissues of various animals. For example, nano-sized and nanocrystalline calcium orthophosphates in the form of apatites of biological origin represent the basic inorganic building blocks of bones and teeth of mammals. Namely, according the recent developments in biomineralization, tens to hundreds nanodimensional crystals of a biological apatite are self-assembled into these complex structures. This process occurs under a strict control by bioorganic matrixes. Furthermore, both a greater viability and a better proliferation of various types of cells have been detected on smaller crystals of calcium orthophosphates. Thus, the nano-sized and nanocrystalline forms of calcium orthophosphates have a great potential to revolutionize the hard tissue-engineering field, starting from bone repair and augmentation to controlled drug delivery systems. This review reports on current state of the art and recent developments on the subject, starting from synthesis and characterization to biomedical and clinical applications. Furthermore, the review also discusses possible directions for future research and development.

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Section: Nanodimensional and Nanocrystalline Calcium Orthophosphates mentioning

confidence: 86%

Nanodimensional and Nanocrystalline Calcium Orthophosphates

Dorozhkin¹

2012

AJBE

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“…Further, nano-hydroxyapatite-PLGA scaffolds support greater rabbit mesenchymal stem cell (MSC) growth and alkaline phosphatase activity than PLGA scaffolds. 12 The addition of nanohydroxyapatite particles into the PLGA scaffold confers better biological, mechanical, and degradation properties.…”

Section: Nanomaterials For Bone Regenerationmentioning

confidence: 99%

Nanomaterials enhance osteogenic differentiation of human mesenchymal stem cells similar to a short peptide of BMP-7

Lock¹,

Liu²

2011

IJN

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Background: Nanomaterials have unique advantages in controlling stem cell function due to their biomimetic characteristics and special biological and mechanical properties. Controlling adhesion and differentiation of stem cells is critical for tissue regeneration. Methods: This in vitro study investigated the effects of nano-hydroxyapatite, nano-hydroxyapatitepolylactide-co-glycolide (PLGA) composites, and a bone morphogenetic protein (BMP-7)-derived short peptide (DIF-7c) on osteogenic differentiation of human mesenchymal stem cells (MSC). The peptide was chemically functionalized onto nano-hydroxyapatite, incorporated into a nanophase hydroxyapatite-PLGA composite or PLGA control, or directly injected into culture media. Results: Unlike the PLGA control, the nano-hydroxyapatite-PLGA composites promoted adhesion of human MSC. Importantly, nano-hydroxyapatite and nano-hydroxyapatite-PLGA composites promoted osteogenic differentiation of human MSCs, comparable with direct injection of the DIF-7c peptide into culture media. Conclusion: Nano-hydroxyapatite and nano-hydroxyapatite-PLGA composites provide a promising alternative in directing the adhesion and differentiation of human MSC. These nanocomposites should be studied further to clarify their effects on MSC functions and bone remodeling in vivo, eventually translating to clinical applications.

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“…For example, hydroxyapatite/PLGA composites possess the osteoconductive properties of hydroxyapatite and biodegradability of PLGA [91]. Polycaprolactone-tricalcium phosphate (PCL-TCP) scaffolds combined with recombinant human BMP7…”

Section: Metallic and Composite Scaffoldsmentioning

confidence: 99%

Bone Graft Substitutes for Bone Defect Regeneration. A Collective Review

Kheirallah¹,

Almeshaly²

2016

IJDOS

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Objective: The purpose of this review article is to illustrate the current state of development of bone graft substitutes that could be used for bone defect regeneration, as well as to analyze their efficacy for clinical use. Methods: An electronic search of the PubMed, was performed for articles written in English. The focused question was "ideal graft substitute material to choose in clinical practice"?. The searches were limited to articles including: bone graft, bone defect scaffold, bone substitutes, and bone regeneration. An attempt was made to identify clinical studies. During the data collection, the data were extracted from the studies including scaffold material, properties and advantages of bone substitutes, as well as clinical results if the study has been provided clinically. Results: In spite of several acceptable scaffold options available for bone regeneration, these options still need to bridge the gap between research and clinical practice. There is little information available about the cellular basis for bone regeneration in humans. Several problems limit the broad usage of such options, including lack of randomized controlled human studies, and dubious long term results. Conclusion:The studies should be nurtured and monitored by a combination of clinical experience. Future trends may focus on the effective combinations of osteoinductive materials, osteoinductive growth factors and cell-based tissue regeneration tactics using composite carriers. There is no single ideal graft material to choose in clinical practice, therefore researches are ongoing in all relevant fields, to establish modern bone regeneration protocols that may lead to the innovation of ideal graft substitutes.

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Preparation and Properties of Poly(lactide-co-glycolide) (PLGA)/ Nano-Hydroxyapatite (NHA) Scaffolds by Thermally Induced Phase Separation and Rabbit MSCs Culture on Scaffolds

Cited by 124 publications

References 40 publications

Nanodimensional and Nanocrystalline Calcium Orthophosphates

Nanodimensional and Nanocrystalline Calcium Orthophosphates

Nanomaterials enhance osteogenic differentiation of human mesenchymal stem cells similar to a short peptide of BMP-7

Bone Graft Substitutes for Bone Defect Regeneration. A Collective Review

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