Preparation and Properties of Tablets Prepared from Furosemide-PVP Solid Dispersion Systems

Development of Tablet Formulation of Amorphous Solid Dispersions Prepared by Hot Melt Extrusion Using Quality by Design Approach

“…In the present study, it was observed that crospovidone was more effective disintegrant compared to croscarmellose sodium and SSG for PVP VA64-containing HME tablets. Crospovidone has porous particle morphology, which facilitates rapid penetration of liquid into the tablet, as noted by Akbuga et al (17). In addition, due to its high crosslink density crospovidone swells rapidly in water without gelling.…”

“…These dissolution results of PVP VA64-containing HME tablets clearly suggest that not only the solid dispersion components (intragranular excipients) but the extragranular components as well can positively or negatively impact the dissolution performance; hence, selection of these components requires careful evaluation while developing solid dispersion dosage form for any given compound. Similarly, other researchers have also observed differences in dissolution properties of the HME tablets when different types of extragranular excipients such as fillers and disintegrants are used (17,22,34).…”

“…The polymers that are commonly used to form solid dispersions such as polyvinyl pyrrolidone (PVP), polyvinyl pyrrolidone co-vinyl acetate 64 (PVP VA64), hydroxypropyl methylcellulose (HPMC), polyethylene oxide (PEO), and hydroxyl propyl cellulose (HPC) have high binding and also gelling properties; hence, their presence in high level in the solid dispersion can result in very long disintegration time of tablets or capsules. It has also been observed that solid dispersions could be less compactible compared to the physical mixture of the blend, which could be attributed to the changes in mechanical properties of the polymer when the blend is passed through the extruder at high temperature and pressure (17,18). During extrusion, the reduced free volume retards molecular mobility, which can prevent further densification during tableting thereby reducing the tensile strength of extrudates (19).…”

Application of Polyglycolized Glycerides in Protection of Amorphous Form of Etoricoxib during Compression

“…Amorphous drug prepared by super critical fluid precipitation has been formulated in the inhalers/spray. Akbuga et al reported tablets of furosemide-PVP solid dispersion but it has limitations like large amount of disintegrants were required for disintegration of tablet 2) compression difficulties were encountered due to sticking to punches and dies.3) Pirttimaki et al reported the polymorphic transformation of caffeine in the tableting, 4) because during tableting material obtains energy from mechanical pharmaceutical operations like mixing, grinding, granulation, drying and tableting necessary for transformation.In an effort to prevent polymorphic transformation of amorphous indomethacin and stabilization of enzymes, Picker et al has evaluated carrageenan, a polymer with high viscoelastic property. It was found to be superior to microcrystalline cellulose, the effect was attributed to the high elasticity of carrageenan during tableting.…”

“…Amorphous drug prepared by super critical fluid precipitation has been formulated in the inhalers/spray. Akbuga et al reported tablets of furosemide-PVP solid dispersion but it has limitations like large amount of disintegrants were required for disintegration of tablet 2) compression difficulties were encountered due to sticking to punches and dies.…”