Preparation and release behavior of carboxylated cellulose nanocrystals-alginate nanocomposite loaded with rutin

Asri, Lia Amelia Tresna Wulan; Rahmatika, Amelia; Fahreza, Muhammad; Insanu, Muhamad; Purwasasmita, Bambang Sunendar

doi:10.1088/2053-1591/aad5d3

Cited by 6 publications

(3 citation statements)

References 34 publications

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“…The crystallinity of CNC accounted for 41.4% based on the ratio of crystalline area to the total scattered intensity and average crystallite size of 3.274 nm. Previously, we have reported CNC isolation with the APS method resulted in dominantly whisker morphology with 80% crystallinity [30]. The lack of ultrasound treatment and the inability of APS to dissolve amorphous cellulose resulted in low crystallinity.…”

Section: Isolation Of Cncmentioning

confidence: 97%

“…CNC was isolated from pineapple leaf fiber through a modified procedure [21,30]. Pineapple fibers were cut into small pieces.…”

Section: Isolation Of Cnc From Pineapple Leaf Fibermentioning

confidence: 99%

“…PVA-CNC hydrogel samples (50 mg) were utterly soaked in distilled water at room temperature at a predetermined time (10,20,30,60,120,240,360, 720, and 1440 min). Each swollen sample was taken out and weighed immediately after adsorbing excess water on its surface with filter paper.…”

Section: Swelling Testmentioning

confidence: 99%

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Polyvinyl Alcohol-Cellulose Nanocrystal Hydrogel Containing Anti-inflammatory Agent

et al. 2022

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Hydrogel wound dressings were developed through cross-linking reactions of polyvinyl alcohol (PVA) with glutaraldehyde and by the addition of diclofenac sodium and rutin as anti-inflammatory agents. Cellulose nanocrystals (CNC) were added to improve mechanically and release properties. CNC was isolated from pineapple leaf fibers through the ammonium persulfate method resulting in a mixture of rod-like whisker and spherical morphology. The mechanical properties of hydrogels are increasing with the addition of CNC. Hydrogels containing 8% CNC exhibited 7.266 N/mm2 tensile strength, 156.3% maximum strain, and 700.3 N/mm2 elastic modulus. Drug release tests containing sodium diclofenac were done by taking incubated phosphate buffer saline samples in a pH 7.4 environment and showed that all CNC variations tested are controllable for the first 30 min compared to the sample without CNC. Sodium diclofenac is easily eluted from hydrogel due to its polar properties, and all samples almost demonstrated the same release profile. PVA hydrogels showed fluctuating concentrations of diclofenac compared to others. While hydrogels containing rutin showed a controlled release mode, the addition of CNC in PVA resulted in a slower release of rutin, possibly due to the better binding between CNC and rutin. To conclude, CNC has successfully improved the performance of PVA hydrogels, including the drug release properties.

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Section: Isolation Of Cncmentioning

confidence: 97%

“…CNC was isolated from pineapple leaf fiber through a modified procedure [21,30]. Pineapple fibers were cut into small pieces.…”

Section: Isolation Of Cnc From Pineapple Leaf Fibermentioning

confidence: 99%