Preparation and release profiles of cyclophosphamide from segmented polyurethanes

Iskakov, Rinat; Batyrbekov, Erkesh O.; Leonova, M. B.; Zhubanov, B. A.

doi:10.1002/(sici)1097-4628(20000103)75:1<35::aid-app5>3.3.co;2-u

Cited by 5 publications

(5 citation statements)

References 5 publications

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“…The structure and morphology of the polymers are important controlling factors in the release of drugs. 25,26 Figure 7 shows the release pattern of p-nitroaniline from polyurethane matrices where the fractional release is plotted against the square root of time. Figure 7(A) shows the effect of different soft segments with variable molecular weight.…”

Section: Release Characteristicsmentioning

confidence: 99%

Structure‐property relationship of L‐tyrosine‐based polyurethanes for biomaterial applications

Sarkar

Yang

Lopina

2008

J of Applied Polymer Sci

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The structure-property relationship of L-tyrosine-based polyurethanes was demonstrated by using different polyols and diisocyanates. L-tyrosine-based chain extender, desaminotyrosyl tyrosine hexyl ester (DTH), was used to synthesize a series of polyurethanes. Polyethylene glycol (PEG) or poly caprolactone diol (PCL) was used as the soft segment and hexamethylene diisocyanate (HDI) or dicyclohexylmethane 4,4 0 -diisocyanate (HMDI) was used with DTH as the hard segment. The polyurethanes were characterized to investigate the effect of structure on different polyurethane properties. From FTIR and DSC, these polyurethanes exhibit a wide range of morphology from phase-mixed to phase-separated structure. The decreasing molecular weight of the PEG soft segment leads to relatively more phase mixed morphology whereas for PCLbased polyurethanes the extent of phase mixing is less with decreasing PCL molecular weight. Results show that PCLbased polyurethanes are mechanically stronger than PEGbased polyurethanes but PCL-based polyurethanes degrade slower and absorb less water compared with PEG-based polyurethanes. The HMDI-based polyurethanes are less crystalline and comparatively more hydrophobic than HDIbased polyurethanes. The characterization results show that the polyurethane properties are directly related to the structure and can be varied easily for a different set of properties that are pertinent for biomaterial applications.

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Section: Release Characteristicsmentioning

confidence: 99%

Structure‐property relationship of L‐tyrosine‐based polyurethanes for biomaterial applications

Sarkar

Yang

Lopina

2008

J of Applied Polymer Sci

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“…The release of p ‐nitroaniline, a model hydrophobic drug, was studied to investigate the effect of polyurethane structure on the release pattern of the drug. The structure and morphology of the polymers are important controlling factors in the release of drugs 25, 26. Figure 7 shows the release pattern of p ‐nitroaniline from polyurethane matrices where the fractional release is plotted against the square root of time.…”

Section: Resultsmentioning

confidence: 99%

Broadband bandpass filter using parallel‐coupled microstrip line and coupled open stub resonator

Marimuthu

Abbosh

Henin

2013

Micro & Optical Tech Letters

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A novel broadband bandpass filter with multiple resonant modes based on parallel‐coupled microstrip line is proposed. The required cutoff frequency and out‐of‐band performance are achieved by placing L‐shaped capacitive cross‐coupling open stubs at the middle resonator with appropriate dimensions. A compact broadband bandpass filter of dimensions 18 × 29 mm2 is fabricated and tested for performance confirmation. The proposed filter demonstrates a wide bandwidth (from 3 to 7 GHz), as well as excellent out‐of‐band performance with more than 25‐dB rejection up to more than 12 GHz and sharp upper cutoff frequency due to the proper location of two transmission zeros. © 2013 Wiley Periodicals, Inc. Microwave Opt Technol Lett 55:1640–1644, 2013; View this article online at wileyonlinelibrary.com. DOI 10.1002/mop.27637

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“…These results indicate that the supermolecular structure design of segmented polyurethanes allows for control of anticancer drug release from the polymer matrix [4,5]. An ideal cancer chemotherapy is to enhance the local concentration of anticancer drugs around the cancer tissue with their reduced total concentration and side effects.…”

Section: Resultsmentioning

confidence: 99%

Segmented Polyurethane/Collagen Blends for Biomedical Application

Batyrbekov¹,

Iskakov²,

Esenalina³

et al. 2005

MRS Proc.

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In the present study the preparation of biomedical devices and some biomedical application of implantable devices based on segmented polyurethane (SPU)/collagen blends have been described. SPU with different content of hard and soft segments were synthesised by a two-step polymerization using a number of polyethylene and propylene glycols and tolylene diisocyanate.The successful biomedical application of SPU/collagen blends as biomaterials at some fields of medicine has been shown. These blends were used for the fabrication of artificial esophageal prostheses for treatment of injures and diseases of esophagus such as chemical burns, cicatrical structures, total stenosis in children when standard technique of surgical bypass of the nonfunctioning esophagus can not be used. The SPU/collagen blends containing anticancer agents were used for treatment of sarcoma of the orbit. It was established that the anticancer effect against Rhabdomiosarcoma of implanted blends prolongs 17-20 days and the toxic effects decrease due to reduce a total therapeutic dose from 2,0 mg/kg to 1,4 mg/kg.Microparticles of SPU with diameter 200-500 microns were prepared with watertoluene interface emulsion polycondensation of toluene-2,4-diisocyanate and poly(ethylene glycol) of various molecular weight 400-2000. The current procedure allows to develop a series of microcapsulated drug delivery forms for respiratory therapeutic use. A method of exterior nose correction using a biocompatible SPU/collagen blend has been developed. The successful application of polyurethane films for reconstruction of the bridge and septum of nose in 15 patients was described.

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Preparation and release profiles of cyclophosphamide from segmented polyurethanes

Cited by 5 publications

References 5 publications

Structure‐property relationship of L‐tyrosine‐based polyurethanes for biomaterial applications

Structure‐property relationship of L‐tyrosine‐based polyurethanes for biomaterial applications

Broadband bandpass filter using parallel‐coupled microstrip line and coupled open stub resonator

Segmented Polyurethane/Collagen Blends for Biomedical Application

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