Preparation and self-assembly of amphiphilic triblock copolymers with polyrotaxane as a middle block and their application as carrier for the controlled release of Amphotericin B

Zhang, Xiaowen; Zhu, Xingqi; Ke, Fuyou; Ye, Lin; Chen, Er-qiang; Zhang, Aiying; Feng, Zeng‐guo

doi:10.1016/j.polymer.2009.07.006

Cited by 69 publications

(76 citation statements)

References 48 publications

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“…A similar competition between pseudopolyrotaxane formation and inclusion complexation with HPMA monomer was observed when Feng and coworkers developed b-cyclodextrin/Pluronic F127 polyrotaxanes. [47][48][49] In the latter explanation, the low concentration of rhodamine B may be attributed to the low incorporation of 11 during the copolymerization and/or cleavage of rhodamine B from the polymer via hydrolysis due to the long-term exposure of the ester linkage to water during adjacent purification. 12 was then evaluated for osteotropicity in vitro, where rhodamine B served as a traceable drug surrogate.…”

Section: Resultsmentioning

confidence: 99%

The Synthesis of a Multiblock Osteotropic Polyrotaxane by Copper(I)‐Catalyzed Huisgen 1,3‐Dipolar Cycloaddition

Hein

Liu

Chen

et al. 2010

Macromolecular Bioscience

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The design and synthesis of a novel bone-targeting polyrotaxane delivery system that utilizes alendronate (ALN) as targeting moiety is presented in this manuscript. For the introduction of ALN, it is first conjugated to α-cyclodextrin (α-CD) and subsequently threaded onto a short poly(ethylene glycol) (PEG) chain, forming a pseudopolyrotaxane. Using click chemistry, this assembly is copolymerized with bulky monomers that bear imaging and/or therapeutic agent(s) to prevent ALN-functionalized α-CD from dethreading. Overall bone affinity of this novel polymer conjugate can be easily controlled by changing the number of ALN-α-CD incorporated. The osteotropicity of the delivery system was also confirmed in vivo.

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Section: Resultsmentioning

confidence: 99%

The Synthesis of a Multiblock Osteotropic Polyrotaxane by Copper(I)‐Catalyzed Huisgen 1,3‐Dipolar Cycloaddition

Hein

Liu

Chen

et al. 2010

Macromolecular Bioscience

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“…Diameters of the particles seen in TEM micrographs are comparable with the values also measure by DLS. However, discrepancy between values determined by both techniques could be attributed to the fact that in the DLS analysis the micelles are hydrated while TEM images are acquired for dried samples [3,42].…”

Section: Diameter Of the Micellesmentioning

confidence: 99%

Synthesis and micellization properties of triblock copolymers PDMAEMA-b-PCL-b-PDMAEMA and their applications in the fabrication of amphotericin B-loaded nanocontainers

Diaz

Pérez

2014

Colloid Polym Sci

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In this study, we report the synthesis of PDMAEMA-b-PCL-b-PDMAEMA via ATRP starting from two dibromide-end polycaprolactone (PCL) of 2 and 10 kDa. The copolymerization was confirmed by nuclear magnetic resonance and gel permeation chromatography. The micellar properties of copolymers with different compositions were studied at pH 5.0, 6.0, 7.0, and 7.5. According to results, properties such as critical micellar concentration (CMC), hydrophobicity of micelle cores, and particle size strongly depend on the length of PCL. The pH shows an important effect on the size of the colloidal aggregates. Micelles obtained from copolymers with the lowest polymerization degree of both segments showed to be more appropriate for the encapsulation of amphotericin B (AmB).

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“…24 Briefly, amphotericin B and PLAg-CS copolymer were dissolved in dimethylsulfoxide. The solution was stirred at room temperature for 1.5 hours and then dialyzed against deionized water for 24 hours using a dialysis bag (molecular weight cutoff 3,500).…”

Section: Preparation Of Amb/pla-g-cs Nanoparticlesmentioning

confidence: 99%

Self-aggregated nanoparticles based on amphiphilic poly(lactic acid)-grafted-chitosan copolymer for ocular delivery of amphotericin B

Zhou¹,

Wang²,

Jian³

et al. 2013

IJN

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Preparation and self-assembly of amphiphilic triblock copolymers with polyrotaxane as a middle block and their application as carrier for the controlled release of Amphotericin B

Cited by 69 publications

References 48 publications

The Synthesis of a Multiblock Osteotropic Polyrotaxane by Copper(I)‐Catalyzed Huisgen 1,3‐Dipolar Cycloaddition

The Synthesis of a Multiblock Osteotropic Polyrotaxane by Copper(I)‐Catalyzed Huisgen 1,3‐Dipolar Cycloaddition

Synthesis and micellization properties of triblock copolymers PDMAEMA-b-PCL-b-PDMAEMA and their applications in the fabrication of amphotericin B-loaded nanocontainers

Self-aggregated nanoparticles based on amphiphilic poly(lactic acid)-grafted-chitosan copolymer for ocular delivery of amphotericin B

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