Preparation and stabilization of simple and multiple emulsions using a microporous glass membrane

Mine, Yoshinori; Nakashima, Tadao

doi:10.1016/0927-7765(95)01264-8

Cited by 88 publications

(50 citation statements)

References 9 publications

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“…[103] revealed that to make a stable W/O/W emulsion, the concentration of internal water droplets must be between 30 and 50 % (v/v), and the membrane pore size for the second step emulsification must be no less than twice the diameter of the internal droplets.…”

Section: Single Emulsion Productionmentioning

confidence: 99%

Recent developments in manufacturing emulsions and particulate products using membranes

Vladisavljević

Williams

2005

Advances in Colloid and Interface Science

325

196

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Membrane emulsification is a relatively new technique for the highly controlled production of particulates. This review focuses on the recent developments in this area, ranging from the production of simple oil-in-water (O/W) or water-in-oil (W/O) emulsions to multiple emulsions of different types, solid-in-oil-in-water (S/O/W) dispersions, coherent solids (silica particles, solid lipid microspheres, solder metal powder), and structured solids (solid lipid microcarriers, gel microbeads, polymeric microspheres, core-shell microcapsules and hollow polymeric microparticles). Other emerging technologies that extend the capabilities into different membrane materials and operation methods (such as rotating membranes, repeated membrane extrusion of coarsely pre-emulsified feeds) are introduced. The results of experimental work carried out by cited researchers in the field together with those of the current authors are presented in a tabular form in a rigorous and systematic manner. These demonstrate a wide range of products that can be manufactured using different membrane approaches. Opportunities for creation of new and novel entities are highlighted for low throughput applications (medical diagnostics, healthcare) and for large scale productions (consumer and personal products).

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Section: Single Emulsion Productionmentioning

confidence: 99%

Recent developments in manufacturing emulsions and particulate products using membranes

Vladisavljević

Williams

2005

Advances in Colloid and Interface Science

325

196

View full text Add to dashboard Cite

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“…Before starting the emulsification process, SPG membrane was dipped into the continuous phase and subjected to ultrasonic treatment for 30 min in order to wet the membrane thoroughly with the continuous phase. 17) The dispersed phase was pumped under gas pressure through the pores of the membrane into the continuous phase, which circulated through the membrane module to form the W/O/W microemulsion droplets. The experiments were carried out over a wide range of feed pressures (50-90 kPa) and agitator speeds (150-450 rpm), at 25°C to optimize the process parameters.…”

Section: Methodsmentioning

confidence: 99%

“…15) The multiple emulsions are produced by forcing a primary emulsion (W/O) through a microporous membrane into a continuous aqueous phase. [16][17][18][19] This results in much less shear than in conventional emulsification processes so that the droplets are intact and both a high entrapment efficiency and monodispersity could be achieved. 20,21) In the present work, we prepared the doxorubicin (DOX)-loaded W/O/W microemulsions using membrane emulsification by pressurizing the premixed W/O emulsions into the external water phase through SPG membrane.…”

mentioning

confidence: 99%

Fabrication, Characterization and Pharmacokinetic Evaluation of Doxorubicin-Loaded Water-in-Oil-in-Water Microemulsions Using a Membrane Emulsification Technique

Pradhan

Kim

Jeong

et al. 2014

CHEMICAL & PHARMACEUTICAL BULLETIN

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Doxorubicin (DOX)-loaded water-in-oil-in-water (W/O/W) microemulsions were produced using a shirasu-porous-glass (SPG) membrane emulsification technique. Soybean oil was used as the oil phase; polyglycerol polyricinoleate (PGPR) or tetraglycerol polyricinoleate (TGPR) was used as the surfactant to stabilize the feed W/O emulsions, while Tween 20 was used in the external water phase to stabilize oil droplets containing water droplets. Increasing the feed pressure from 50 to 90 kPa increased the particle size of W/O/W emulsions, whereas it was decreased by increasing the agitator speed. The smallest particle sizes of multiple emulsions were obtained at the feed pressure of 50 kPa and agitator speed of 350 rpm. Under this set of conditions, the increase in the concentration of PGPR or TGPR showed a decrease in the particle size of DOX-loaded W/O/W emulsions. The optimized formulation comprising of 5% w/v PGPR and 3% w/v Tween 20 in the oil phase and external water phase, respectively, with 0.5% w/v of DOX had a particle size of 0.440 0.007 µm and polydispersity index of 0.220 0.087, which was supported by the transmission electron microscopy image. The formulations showed a sustained release profile in phosphate buffer solution (pH 7.4). The plasma concentrations of DOX after intravenous administration to rats were prolonged and gave approximately 17-fold higher area under the drug concentration-time curve (AUC) compared to free DOX solution. Thus, these results demonstrated that the SPG membrane emulsification technique could be used as a promising technique to prepare W/O/W microemulsions for delivering DOX with sustained release characteristics and better bioavailability.Key words microemulsion; shirasu-porous-glass; doxorubicin; sustained release; pharmacokinetics Over the past two decades, an increasing interest has been devoted to multiple emulsions due to their multiple compartment structure and an immense capability of encapsulating hydrophilic drug substances for sustained released characteristics. [1][2][3][4] The potential application of water-in-oil-in-water (W/O/W) multiple emulsion is not only limited to pharmaceuticals but also in the field of cosmetics and food industry. In cosmetics and pharmaceuticals, W/O/W emulsions have been used for controlled release and targeted delivery of drugs. [5][6][7][8] Food applications include the encapsulation of vitamin/minerals, 9,10) and the production of low-calorie foods. 11) W/O/W emulsions are usually created using conventional homogenization technology in a two-step procedure. 12) First, a primary water-in-oil (W/O) emulsion is prepared by homogenizing an oil phase and an aqueous phase together in the presence of a suitable oil-soluble emulsifier (low hydrophilic to lipophilic balance (HLB)<10). Second, W/O/W emulsion is prepared by homogenizing W/O emulsion with another aqueous phase in the presence of a suitable water-soluble emulsifier (high HLB>10). 1) However, the second step often results in high polydispersity or low encapsulation efficiency. Therefo...

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“…µm. If the pore diameter of the membrane is equal to or smaller than the diameter of the water particles, the water particles will be rejected by the membrane so that it will be impossible to obtain a W/O/W emulsion [27]. In this case, the maximum size of the water droplets was one order of magnitude smaller than the pore size.…”

Section: Oscillating Membrane Emulsification Rigmentioning

confidence: 99%

Production of food-grade multiple emulsions with high encapsulation yield using oscillating membrane emulsification

Vladisavljević

Wang

Dragosavac

et al. 2014

Colloids and Surfaces A: Physicochemical and Engineering Aspect

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Preparation and stabilization of simple and multiple emulsions using a microporous glass membrane

Cited by 88 publications

References 9 publications

Recent developments in manufacturing emulsions and particulate products using membranes

Recent developments in manufacturing emulsions and particulate products using membranes

Fabrication, Characterization and Pharmacokinetic Evaluation of Doxorubicin-Loaded Water-in-Oil-in-Water Microemulsions Using a Membrane Emulsification Technique

Production of food-grade multiple emulsions with high encapsulation yield using oscillating membrane emulsification

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