Preparation, characterization, and antibiofilm activity of cinnamic acid conjugated hydroxypropyl chitosan derivatives

Yue, Lin; Wang, Min; Khan, Imran Mahmood; Xu, Jianguo; Peng, Chifang; Wang, Zhouping

doi:10.1016/j.ijbiomac.2021.08.164

Cited by 35 publications

(8 citation statements)

References 82 publications

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“…In addition to the increased protection of microorganisms in biofilms, the matrix allows improved communication between bacteria and increases resistance by allowing bacteria to remain in a dormant state for prolonged periods [103,107]. These biofilm matrices are found in approximately 60-80% of all human infections [110], and bacteria in biofilms are often 1000-fold more resistant than planktonic bacteria, further increasing the challenge in eradicating these pathogens [111]. Fungi are also often a part of the polymicrobial community in chronic wounds, and Candida spp.…”

Section: Common Skin Infections and Microorganismsmentioning

confidence: 99%

The Expanded Role of Chitosan in Localized Antimicrobial Therapy

2021

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Chitosan is one of the most studied natural origin polymers for biomedical applications. This review focuses on the potential of chitosan in localized antimicrobial therapy to address the challenges of current rising antimicrobial resistance. Due to its mucoadhesiveness, chitosan offers the opportunity to prolong the formulation residence time at mucosal sites; its wound healing properties open possibilities to utilize chitosan as wound dressings with multitargeted activities and more. We provide an unbiased overview of the state-of-the-art chitosan-based delivery systems categorized by the administration site, addressing the site-related challenges and evaluating the representative formulations. Specifically, we offer an in-depth analysis of the current challenges of the chitosan-based novel delivery systems for skin and vaginal infections, including its formulations optimizations and limitations. A brief overview of chitosan’s potential in treating ocular, buccal and dental, and nasal infections is included. We close the review with remarks on toxicity issues and remaining challenges and perspectives.

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Section: Common Skin Infections and Microorganismsmentioning

confidence: 99%

The Expanded Role of Chitosan in Localized Antimicrobial Therapy

2021

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“…The MBC was determined by the agar plate method adapted from Yue et al . (2021). 10 μL of each well were transferred to Petri dishes containing nutrient agar.…”

Section: Methodsmentioning

confidence: 99%

Improving chitosan properties through ionic and chemical cross‐linking and their impact on emulsified systems

Gonçalves

Duarte

Fiocco

et al. 2023

Int J of Food Sci Tech

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Chitosan (CS) nanoparticles were formed by two different methodologies: ionic (with sodium tripolyphosphate -TPP) and chemical (with genipin -GN) cross-linking. CS-TPP and CS-GN nanoparticles showed positive zeta potential (+46.24 and +62.86 mV, respectively) and sizes ranging from 83.70 to 835.91 nm, respectively. Ionic cross-linking (with TPP) resulted in particles smaller than those formed by chemical cross-linking (with GN). The in vitro antibacterial activity revealed an efficient inhibitory effect, especially regarding CS-TPP. In situ, antibacterial and antioxidant studies were carried out on O/W emulsions. The mesophilic and psychrotrophic counts, peroxide value and quantification of conjugated dienes and trienes during time revealed that nanoparticles tend to improve the microbiological and oxidative stability of emulsions. These findings underline the direct relationship between the reduction of particle size and the increase in biopolymer functional properties and expand the possibilities of CS application as a natural preservative of emulsified systems.

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“…The synthesis method of HPCS and HPCS‐CA derivatives is in accordance with the previous literature published by our research group (Yue et al ., 2021). In this experiment, the degree of substitution (DS) of the hydroxypropyl group in HPCS was 112.99% compared with CS, and the DS of CA in HPCS‐CA derivatives was 74.86% compared with HPCS.…”

Section: Methodsmentioning

confidence: 99%

“…In addition, CA or cinnamaldehyde were directly used as the encapsulation component of the emulsion (Muhoza et al ., 2021), or cinnamaldehyde and CS were conjugated to study the emulsion stability (Chen et al ., 2017; Hu et al ., 2020). By contrast, the HPCS‐CA derivative has good antibacterial activity and can be used in the food system (Yue et al ., 2021). Therefore, the emulsion stabilised by HPCS‐CA Ps has certain antibacterial activity, which can not only expand the application range of the HPCS‐CA derivative but also improve the fresh‐keeping quality of the emulsion system.…”

Section: Introductionmentioning

confidence: 99%

“…In addition, CS has been proved to be a useful emulsifier (Rodriguez et al ., 2002; Li & Xia, 2011). In our previous study, hydroxypropyl chitosan derivative (HPCS) modified by cinnamic acid (CA) was synthesised and its antibacterial application was explored (Yue et al ., 2021). Because the HPCS‐CA derivative has hydrophilic hydroxypropyl groups and hydrophobic cinnamic acid groups, it is speculated that it has emulsifying properties.…”

Section: Introductionmentioning

confidence: 99%

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Hydroxypropyl chitosan modified by cinnamic acid derivative nanoparticles for stabilising Pickering emulsion

Wang

Yue

Zhao

et al. 2022

Int J of Food Sci Tech

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Summary Chitosan (CS) derivatives, chemically modified appropriately, can be used to produce nanoparticles with good properties. In this work, using CS, hydroxypropyl CS (HPCS) and HPCS modified by cinnamic acid (HPCS‐CA) derivative as raw materials, the nanoparticles were synthesised by ion crosslinking method with tripolyphosphate. FT‐IR spectra indicated that CS and its derivatives successfully cross‐linked with TPP at the molecular level. XRD and TG results exhibited changes in crystallinity and thermal stability. The nanoparticles had narrow size distribution and were nearly spherical. The surfaces of the nanoparticles were all positively charged. The nanoparticles‐stabilised oil‐in‐water Pickering emulsions were obtained by high‐speed homogenisation. The emulsions' morphology was reported by confocal laser scanning microscopy, indicating that the Pickering emulsions were synthesised successfully. The stability of the emulsion stabilised by HPCS‐CA nanoparticles was better than that of CS and HPCS nanoparticles. Taking curcumin as the target component, its stability in Pickering emulsions was good. The Pickering emulsion stabilised by HPCS‐CA nanoparticles may be a novel bioactive compound delivery system.

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Preparation, characterization, and antibiofilm activity of cinnamic acid conjugated hydroxypropyl chitosan derivatives

Cited by 35 publications

References 82 publications

The Expanded Role of Chitosan in Localized Antimicrobial Therapy

The Expanded Role of Chitosan in Localized Antimicrobial Therapy

Improving chitosan properties through ionic and chemical cross‐linking and their impact on emulsified systems

Hydroxypropyl chitosan modified by cinnamic acid derivative nanoparticles for stabilising Pickering emulsion

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