Preparation, characterization and application of a new 25,27‐bis‐[2‐(5‐methylthiadiazole)thioethoxyl]‐26,28‐dihydroxy‐para‐tert‐butyl calix[4]arene stationary phase for HPLC

Hu, Kai; Liu, Junwei; Tang, Chao; Wang, Caijuan; Yu, Ajuan; Wen, Fuyong; Zhao, Wenjie; Ye, Baoxian; Wu, Yangjie; Zhang, Shusheng

doi:10.1002/jssc.201100733

Cited by 16 publications

(5 citation statements)

References 29 publications

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“…There are a number of selective factors in the configuration of calixarenes such as cavity size, conformation, and substituents. Since Glennon and his co-workers reported the application of calixarenes as the stationary phase, it has attracted extensive attention. − Our group has been comitted to the research of calixarene stationary phases for many years, − and a novel multi-interaction and mixed-mode stationary phase based on tetraazacalix[2]arene[2]triazine modified silica gel (NCS, Figure ) has been synthesized in our laboratory in 2012 . Being different from conventional calixarenes in which the aromatic rings are linked by methylene units, tetraazacalix[2]arene[2]triazine assembles aromatic rings by −NH– and adopts a 1,3-alternate conformation with two benzene rings nearly face-to-face parallel and two triazine rings tending to an edge-to-edge orientation in the solid phase.…”

Section: Introductionmentioning

confidence: 99%

Determination of Trace Acrylamide in Starchy Foodstuffs by HPLC Using a Novel Mixed-Mode Functionalized Calixarene Sorbent for Solid-Phase Extraction Cleanup

Zhang

Deng

Zhao

et al. 2014

J. Agric. Food Chem.

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In this paper, a rapid and effective HPLC method, using tetraazacalix[2]arene[2]triazine-modified silica gel (NCSi) as solid-phase extraction (SPE) sorbent, was developed for the purification and determination of trace acrylamide in starchy foodstuffs. The main influence factors of SPE including amount of NCSi sorbent, sample flow rate, and volume and composition of washing solution were investigated and evaluated in the sample pretreatment step. The optimized purification effect was achieved at the sample flow rate of 3 mL/min with 100 mg of NCSi and 2 mL of washing solution (water, 100%). The HPLC separation was carried out on a C18 column (250×4.6 mm i.d., 5 μm) with a mobile phase of methanol/water (10:90, v/v). The linear range of the calibration curve was 4-4000 ng/mL with s correlation coefficient of >0.9999. The intraday and interday RSDs (n=5) of peak areas of acrylamide were 0.22 and 0.90% and the intraday and interday RSDs (n=5) of retention times were 0.50 and 1.63%, respectively. In addition, overall recoveries through the extraction and NCSi-SPE purification ranged from 73.13 to 98%. Compared with the commercial SPE sorbents, NCSi featured excellent selectivity to retain polar and nonpolar interferences in the sample matrices. The improved method was simple, rapid, accurate, and promising for the determination of trace acrylamide in starchy foods with a complex matrix.

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Section: Introductionmentioning

confidence: 99%

Determination of Trace Acrylamide in Starchy Foodstuffs by HPLC Using a Novel Mixed-Mode Functionalized Calixarene Sorbent for Solid-Phase Extraction Cleanup

Zhang

Deng

Zhao

et al. 2014

J. Agric. Food Chem.

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“…23,24 Hu et al reported a new 25,27-bis-[2-(5-methylthiadiazole)thioethoxyl]-26,28-dihydroxy-para-tert-butyl calix [4]arene stationary phase for the separation of aromatic amines and anilines. 25 These results conrm the usability of reversephase packing with inclusion capability of calixarene-bonded stationary phases.…”

Section: Introductionmentioning

confidence: 90%

Simultaneous determination of some basic dyes using p-tetranitrocalix[4]arene-appended silica-based HPLC column

Memon

Durmaz

et al. 2014

Anal. Methods

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This study focuses on the synthesis, characterization and application of p-tetranitrocalix[4]arene-appended silica-based material as a stationary phase in high-performance liquid chromatography for the simultaneous separation of some basic dyes such as methyl violet, methyl green and methylene blue. The effect of the pH of mobile phase on the retention, separation and selectivity of these compounds was investigated. The method was validated for system efficiency, linearity, accuracy, precision, limit of detection and quantification. The limits of detection were 0.1, 0.5 and 0.3 mg L À1 ; whereas, the limits of quantification were observed to be 1, 1.2 and 0.9 mg L À1 for methyl violet, methyl green and methylene blue, respectively. The separation efficiency of the p-tetranitrocalix[4]arene-appended silica-based column was also compared to that of the octadecylsilane column.

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“…By modifying them onto the surface of silica gel, calixarenes have been widely studied as solid phase extraction and stationary phase materials. Due to the peculiar structural characteristics of cavity-shape and benzene ring skeleton, these materials can offer varieties of interaction with analytes, such as hydrophobic, hydrogen bonding, π - π , as well as inclusion interaction [23–31]. Nowadays, heterocyclic calixarene appeared as a novel kind of supramolecular compound [32].…”

Section: Introductionmentioning

confidence: 99%

SPE-UHPLC-FLD Method for the Simultaneous Determination of Five Anthraquinones in Human Urine Using Mixed-Mode Bis(tetraoxacalix[2]arene[2]triazine) Modified Silica as Sorbent

Qiao

Deng

et al. 2017

Journal of Analytical Methods in Chemistry

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The five anthraquinones compounds (including aloe-emodin, emodin, physcion, chrysophanol, and rhein) are regarded as the main effective ingredients in rhubarb (Dahuang in Chinese, one of the commonly used Chinese herbal medicines). In this work, a simple and effective solid phase extraction (SPE) method based on bis(tetraoxacalix[2]arene[2]triazine) modified silica gel as adsorbent was developed. Coupled with UHPLC-FLD, the developed method was successfully applied for the measuring of main anthraquinones in human urine after oral administration of the extracts of rhubarb. To obtain the highest recoveries of the five anthraquinones in the SPE process, the main parameters which may affect extraction efficiency were optimized. The optimized sorbent amount, sample loading pH, sample loading rate, washing solution, and eluent condition were obtained. The developed method showed good linearity in 0.012–1.800 μg mL−1 for the five anthraquinones with correlation coefficients more than 0.9993. The investigated LOD values ranged from 3.9 to 5.7 ng mL−1, while the LOQs were between 12.0 and 18.2 ng mL−1. The recoveries of the method were also investigated, which were in the range of 94.8–106.6%. The application of the mixed-mode SPE materials in the proposed method was feasible and simple, and suitable for the enrichment of anthraquinones in urine samples.

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Preparation, characterization and application of a new 25,27‐bis‐[2‐(5‐methylthiadiazole)thioethoxyl]‐26,28‐dihydroxy‐para‐tert‐butyl calix[4]arene stationary phase for HPLC

Cited by 16 publications

References 29 publications

Determination of Trace Acrylamide in Starchy Foodstuffs by HPLC Using a Novel Mixed-Mode Functionalized Calixarene Sorbent for Solid-Phase Extraction Cleanup

Determination of Trace Acrylamide in Starchy Foodstuffs by HPLC Using a Novel Mixed-Mode Functionalized Calixarene Sorbent for Solid-Phase Extraction Cleanup

Simultaneous determination of some basic dyes using p-tetranitrocalix[4]arene-appended silica-based HPLC column

SPE-UHPLC-FLD Method for the Simultaneous Determination of Five Anthraquinones in Human Urine Using Mixed-Mode Bis(tetraoxacalix[2]arene[2]triazine) Modified Silica as Sorbent

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