Preparation, Characterization and Evaluation of Floating Microparticles of Ciprofloxacin

Objective: The objective of this study was to formulate and evaluate the drug release studies using locust bean gum (LBG) and sodium alginate (NaAlg) and cross-linked with glutaraldehyde for the controlled release (CR) of Nimesulide, an anti-inflammatory drug.Methods: Locust bean gum (LBG) and sodium alginate (NaAlg) blend hydrogel beads were prepared by an extrusion method using glutaraldehyde as a crosslinker. Nimesulide an anti-inflammatory drug was encapsulation within LBG/NaAlg blend hydrogel beads. Morphology, size, encapsulation efficiency and drug release from these hydrogel beads were evaluated by different characterization techniques such as fourier transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC), scanning electron microscopy (SEM), x-ray diffraction (X-RD) studies.Results: Drug-loaded hydrogel beads were analyzed by FTIR, which indicates the interaction between drug and polymers. DSC thermograms on drug-loaded microbeads confirmed the polymorphism of Nimesulide and indicated a molecular level dispersion of the drug in the hydrogel beads. SEM confirmed the spherical nature and rough surface of the hydrogel beads produced. X-RD study was performed to understand the crystalline nature of drug after encapsulated into the hydrogel beads and confirmed the complete dispersion of the drug in the polymer matrix. In vitro release studies conducted in pH-7.4 which indicated a dependence of release rate on the amount of drug loading and the amount of LBG/NaAlg, but slow release rates were extended up to 48 h. The cumulative release data were fitted to an empirical equation to compute diffusion exponent (n) which indicated the non-fickian trend for drug release. Conclusion:These results clearly demonstrated that the ability of these newly developed hydrogel beads containing Nimesulide for its sustained release could possibly be advantageous to patient compliance with reduced dosing interval.

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“…Drug release kinetics was analyzed by plotting the cumulative release data Vs time by fitting to the empirical equation [37].…”

Section: Drug Release Kineticsmentioning

confidence: 99%

Sodium Alginate–locust Bean Gum Ipn Hydrogel Beads for the Controlled Delivery of Nimesulide-Anti-Inflammatory Drug

Madhavi¹,

Babu²,

Maruthi³

et al. 2017

Int J Pharm Pharm Sci

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“…In comparison to the MCM-41 spectrum, the spectrum of MCM-41-CIP presented additional bands at 1715 cm −1 , 1494 cm −1 , and 1459 cm −1 , which were also observed in the spectrum of freeze-dried CIP confirming the drug adsorption onto the MCM-41. These three bands were respectively attributed to the stretching vibrations of C=O, C-H, and aromatic C=C of CIP [55].…”

Section: Molecular Structurementioning

confidence: 99%

Silica-Polymer Composites as the Novel Antibiotic Delivery Systems for Bone Tissue Infection

et al. 2019

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Bone tissue inflammation, osteomyelitis, is commonly caused by bacterial invasion and requires prolonged antibiotic therapy for weeks or months. Thus, the aim of this study was to develop novel silica-polymer local bone antibiotic delivery systems characterized by a sustained release of ciprofloxacin (CIP) which remain active against Staphylococcus aureus for a few weeks, and do not have a toxic effect towards human osteoblasts. Four formulations composed of ethylcellulose (EC), polydimethylsiloxane (PDMS), freeze-dried CIP, and CIP-adsorbed mesoporous silica materials (MCM-41-CIP) were prepared via solvent-evaporation blending method. All obtained composites were characterized in terms of molecular structure, morphological, and structural properties by using Fourier Transform Infrared Spectroscopy (FTIR), scanning electron microscopy equipped with energy-dispersive X-ray spectroscopy (SEM/EDX), and X-ray diffraction (XRD), thermal stability by thermogravimetric analysis (TGA) and differential scanning calorimetry (DSC), and in vitro antibiotic release. The antibacterial activity against Staphylococcus aureus (ATCC 6538) as well as the in vitro cytocompatibility to human osteoblasts of obtained composites were also examined. Physicochemical results confirmed the presence of particular components (FTIR), formation of continuous polymer phase onto the surface of freeze-dried CIP or MCM-41-CIP (SEM/EDX), and semi-crystalline (composites containing freeze-dried CIP) or amorphous (composites containing MCM-41-CIP) structure (XRD). TGA and DSC analysis indicated the high thermal stability of CIP adsorbed onto the MCM-41, and higher after MCM-41-CIP coating with polymer blend. The release study revealed the significant reduction in initial burst of CIP for the composites which contained MCM-41-CIP instead of freeze-dried CIP. These composites were also characterized by the 30-day activity against S. aureus and the highest cytocompatibility to human osteoblasts in vitro.

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“…Ropinirole hydrochloride and pramipexole dihydrochloride microspheres were prepared by solvent evaporation technique using a different amount of eudragit RS100, eudragit RL100 and ethylcellulose [6][7][8] F and M = formulation code…”

Section: Formulation Of Ropinirole Hydrochloride and Pramipexole Dihymentioning

confidence: 99%

Evaluation of Stability of Ropinirole Hydrochloride and Pramipexole Dihydrochloride Microspheres at Accelerated Condition

Kar

Pal²,

Nandi

2018

Int J App Pharm

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Objective: The objective of the present work was to conduct accelerated stability study as per international council for harmonisation (ICH) guidelines and to establish shelf life of controlled release dosage form of ropinirole hydrochloride and pramipexole dihydrochloride microspheres for a period of 6 mo.Methods: Most optimized batch of ropinirole hydrochloride and pramipexole dihydrochloride (F12 and M12 respectively) were selected and subjected to exhaustive stability testing by keeping the sample in stability oven for a period of 3 and 6 mo. Various parameters like surface morphology, particle size, drug content, in vitro drug release and shelf life were evaluated at 3 and 6 mo period. The surface morphology of the formulated microspheres was determined by scanning electron microscopy (SEM). The particle size of the microspheres was estimated by optical microscopy method. The drug content was assayed by the help of ultra-violet spectrophotometer (UV). The in vitro drug release was performed by using Paddle II type dissolution apparatus and the filtrate was analyzed by UV spectrophotometer. The shelf life of the optimized microspheres was calculated by using the rate constant value of the zero-order reaction.Results: A minor change was recorded in average particle size of F12 and M12 microspheres after storage for 6 mo. For F12 and M12, initially the particle size was 130.00 µm and 128.92 µm respectively and after 6 mo it was found to be 130.92 µm and 128.99 µm respectively. There was no change in surface morphology of F12 and M12 microspheres after 6 mo of storage. The shape of microspheres remained spherical and smooth after 6 mo. An insignificant difference of drug content was recorded after 6 mo compared to the freshly prepared formulation. For F12 and M12, 94.50% and 93.77% of the drug was present initially and after 6 mo 94.45% and 93.72% of the drug was recorded. In vitro drug release was recorded after 6 mo for F12 and M12. Initially, 97.99% and 97.69% of the drug was released till 14th hour respectively for F12 and M12. After 6 mo, 98.23% and 97.99% of the drug was released respectively. The percentage residual drug content revealed that the degradation of microspheres was low. Considering the initial percentage residual drug content as 100%, 99.94% of the drug was recorded for both F12 and M12. The shelf life for F12 and M12 was found to be 10 y 52 d and 10 y 70 d respectively which were determined by the zero-order kinetic equation. Conclusion:A more or less similar surface morphology, particle size, drug content and percent of drug release before and after stability study confirmed the stability of F12 and M12 microspheres after storage for 6 mo and prove the efficacy of the microspheres in the site-specific delivery of drugs in Parkinson's disease.

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Preparation, Characterization and Evaluation of Floating Microparticles of Ciprofloxacin

Cited by 27 publications

References 4 publications

Sodium Alginate–locust Bean Gum Ipn Hydrogel Beads for the Controlled Delivery of Nimesulide-Anti-Inflammatory Drug

Sodium Alginate–locust Bean Gum Ipn Hydrogel Beads for the Controlled Delivery of Nimesulide-Anti-Inflammatory Drug

Silica-Polymer Composites as the Novel Antibiotic Delivery Systems for Bone Tissue Infection

Evaluation of Stability of Ropinirole Hydrochloride and Pramipexole Dihydrochloride Microspheres at Accelerated Condition

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