Preparation, characterization and evaluation of liposomal-freeze dried anthocyanin-enriched Vaccinium arctostaphylos L. fruit extract incorporated into fast dissolving oral films

Oçkun, Mehmet Ali; Baranauskaitė, Justė; Uner, Burcu; Kan, Yüksel; Kırmızıbekmez, Hasan

doi:10.1016/j.jddst.2022.103428

Cited by 18 publications

(4 citation statements)

References 60 publications

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“…Since the bioavailability of APIs is one of the crucial aspects in the formulation of orally administered dosage forms, it is the most frequently sought-after improvement in the development of nanostructures designed for this administration route. For this purpose, both polymeric/protein-based [72,[134][135][136][137][138][139] and lipidic nanostructures [131,140] have been employed and included in ODx.…”

Section: Benefits Of the Use Of Nanostructures In Odxmentioning

confidence: 99%

Orally Dispersible Dosage Forms for Paediatric Use: Current Knowledge and Development of Nanostructure-Based Formulations

et al. 2022

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The paediatric population has always suffered from a lack of medicines tailored to their needs, especially in terms of accurate dosage, stability and acceptability. Orodispersible dosage forms have gone through a resurrection as an alternative to liquid formulations or fractioned solid formulations, although they are still subject to several inconveniences, among which the unpleasant taste and the low oral bioavailability of the API are the most significant hurdles in the way of achieving an optimal drug product. Nanostructures can address these inconveniences through their size and variety, owing to the plethora of materials that can be used in their manufacturing. Through the formation and functionalisation of nanostructures, followed by their inclusion in orodispersible dosage forms, safe, stable and acceptable medicines intended for paediatric use can be developed.

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Section: Benefits Of the Use Of Nanostructures In Odxmentioning

confidence: 99%

Orally Dispersible Dosage Forms for Paediatric Use: Current Knowledge and Development of Nanostructure-Based Formulations

et al. 2022

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“…To maintain mechanical strength to Orodispersable tablets the range of hardness should lie in between 2-4 kg/ cm 2 . 16 The hardness may impact the other evaluation properties like Disintegration, Dissolution which in turn shows its impact directly on Bioavailability.…”

Section: Tablet Evaluation/characterization Hardnessmentioning

confidence: 99%

Application of Novel Natural Sweetening Agent-Stevia in Formulation, Evaluation of Nicardipine Hydrochloride Orodispersable Tablets for Rapid Absorption

Dasari,

Phani Kumar,

Gummadi

et al. 2024

Ind. J. Pharm. Edu. Res

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Objectives:The objective of this study was to develop a stable and effective form of an Orodispersible tablet containing Nicardipine Hydrochloride for the immediate treatment of high blood pressure and angina. The aim was to achieve this by using the natural sweetener stevia to improve taste. Background: Nicardipine Hydrochloride is used to treat high blood pressure and angina. However, currently available immediate release forms have limitations in terms of drug release and taste. Therefore, the goal was to develop an Orodispersible form of the drug that would enhance drug release and improve taste masking capabilities. Materials and Methods: We developed formulations of Nicardipine Hydrochloride Orodispersible tablets using the natural sweetener Stevia rebaudiana to enhance taste and reduce the caustic sensation. We confirmed the compatibility of the drug-excipient mixture using FTIR. Drug content and dissolution were determined through UV spectrophotometry. We also conducted organoleptic tests and other compendial specification tests. Precompression parameters were evaluated, and measures were taken to improve the flow behavior of the formulation blend by using excipients with excellent flow properties. Based on disintegration and dissolution time, we selected the F6 formulation as the optimized formula. We then subjected the developed trial to stability studies for three months, evaluating disintegration time, drug content, and dissolution. Results: The optimized formulation demonstrated a disintegration time of 46.25±0.85 sec and a dissolution rate of 100.50±2.50. Compendial tests remained stable without any significant fluctuations after the stability study. Also, the taste of the drug was pleasant after taste. Conclusion: Through the appropriate selection of excipients, we successfully developed a stable and effective form of Nicardipine Hydrochloride Orodispersible tablet with enhanced drug release (using the solid dispersion technique) and improved taste masking capabilities. The optimized formulation yielded favorable results in terms of disintegration and dissolution time, drug content, and stability.

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“…2.9.4. ABTS Assay ABTS assay [33] was slightly modified and then applied. Equal volumes (20 µL) of the DSTSs, trolox standard solutions (6.25-100 µg/mL) or methanol (as a blank) were placed in separate wells of a 96-well microplate plate, and ABTS reagent (280 µL) was added.…”

Section: Cuprac Assaymentioning

confidence: 99%

“…[100], 626 [41], 627 [10], 723 [6], 661 [3], 1251 [3] MS 2 [625]: 300 [100], 301 [73], 445 [33], 505 [17], 271 [16], 463 [11], 355 [9], 255 [8], 343 [8], 299 [6], 325 [5], 273 [4], 409 [4], 427 [4], 367 [3] MS 3 [625 → 300]: 271 [100], 255 [61], 272 [12], 254 [7], 243 [3] MS 2 [723]: 625 [100], 399 [34], 437 [21], 687 [21], 685 [21]. 437 [21] MS 3 [723 → 625]: 300 [100], 301 [76], 445 [40], 271 [17], 505 [17], 463 [13] MS 2 [23], 211 [16],…”

Section: Compounds Ms (M/z) [Relative Intensity] Ms N (M/z) [Relative...mentioning

confidence: 99%

Phytochemical and Bioactivity Studies on Hedera helix L. (Ivy) Flower Pollen and Ivy Bee Pollen

et al. 2023

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Bee pollen, known as a ‘life-giving dust’, is a product of honeybees using flower pollen grains and combining them with their saliva secretions. Thus, flower pollen could be an indicator of the bee pollen botanical source. Identification of bee pollen sources is a highly crucial process for the evaluation of its health benefits, as chemical composition is directly related to its pharmacological activity. In this study, the chemical profiles, contents of phenolic marker compounds and pharmacological activities of Hedera helix L. (ivy) bee pollen samples from Türkiye and Slovenia, as well as ivy flower pollen grains, were compared. High-performance thin-layer chromatography (HPTLC) analyses revealed that pollen samples, regardless of where they were collected, have similar chemical profiles due to the fact that they have the same botanical origins. Marker compounds afzelin, platanoside and quercetin-3-O-β-glucopyranosyl-(1→2)-β-galactopyranoside, common to both bee pollen and flower pollen, were isolated from bee pollen, and their structures were elucidated by nuclear magnetic resonance (NMR) and mass spectrometry (MS). These three compounds, as well as chlorogenic acid and 3,5-dicaffeoylquinic acid (found in flower pollen), were quantified using high-performance liquid chromatography (HPLC) analyses. In vitro tests and effect-directed analyses were used to evaluate the xanthine oxidase inhibition and antioxidant activity of the marker compounds and extracts from flower pollen and bee pollen. This is the first report comparing chemical profiles and related bioactivities of the flower pollen and bee pollen of the same botanical origin, as well as the first report of the chemical profile and related bioactivities of ivy flower pollen.

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Preparation, characterization and evaluation of liposomal-freeze dried anthocyanin-enriched Vaccinium arctostaphylos L. fruit extract incorporated into fast dissolving oral films

Cited by 18 publications

References 60 publications

Orally Dispersible Dosage Forms for Paediatric Use: Current Knowledge and Development of Nanostructure-Based Formulations

Orally Dispersible Dosage Forms for Paediatric Use: Current Knowledge and Development of Nanostructure-Based Formulations

Application of Novel Natural Sweetening Agent-Stevia in Formulation, Evaluation of Nicardipine Hydrochloride Orodispersable Tablets for Rapid Absorption

Phytochemical and Bioactivity Studies on Hedera helix L. (Ivy) Flower Pollen and Ivy Bee Pollen

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