Preparation, characterization and hydrolytic degradation of PLA/PCL co-mingled nanofibrous mats prepared via dual-jet electrospinning

Wang

J Polym Sci B Polym Phys

et al. 2019

Superhydrophobic polycaprolactone (PCL) membranes with hierarchical structure were fabricated via alternate electrospinning/electrospraying techniques. Electrospun PCL/methyl silicone oil (PCL/MSO) nanofibers were employed as substrate. PCL/MSO‐PCL microspheres (PCL/MSO‐PCLMS) hierarchical membrane was prepared via electrosprayed PCLMS as an additional layer on the substrate. Field emission scanning electron microscopy images showed the formation of hierarchical PCL/MSO‐PCLMS membranes. Compared to pure PCL fibers substrate (120 ± 1.3°), the water contact angle (WCA) of MSO‐modified PCL membrane was 142 ± 0.7°. The most interesting observation was that the WCA of PCLMS without any modification could be achieved to 146 ± 2.8°. On this basis, PCL/MSO‐PCLMS hierarchical membrane possessed superhydrophobic surface with 150 ± 0.6° of WCA. The excellent surface roughness and air‐pocket capacity of hierarchical membranes would make the membranes more hydrophobic. The maximum oil (n‐hexane) adsorption capacity of PCL/MSO‐PCLMS membrane was 32.53 g g−1. Oil–water separation efficiencies of the superhydrophobic membranes were all higher than 99.93% after 10 cycles. The hierarchically structured PCL superhydrophobic membranes indicate the potential applications of environmentally friendly biopolymers as separation membranes. © 2019 Wiley Periodicals, Inc. J. Polym. Sci., Part B: Polym. Phys. 2019, 57, 421–430

Section: Introductionmentioning

confidence: 99%

Preparation of hierarchically structured PCL superhydrophobic membrane via alternate electrospinning/electrospraying techniques

Wang

J Polym Sci B Polym Phys

et al. 2019

Journal of Nanomaterials

“…Electrospun PLAderived nanofibres in the form of mats have high surface-tovolume ratio and high porosity, and the scaffolds made of such nanofibres degrade differently than bulk PLA-derived implant. The degradation behavior is one of the crucial factors when considering using such scaffolds in tissue engineering [44,45]. The pH and temperature have a distinct effect on the rate of degradation.…”

Section: Journal Of Nanomaterialsmentioning

confidence: 99%

Degradation Behavior of Electrospun PLA and PLA/CNT Nanofibres in Aqueous Environment

Magiera

Markowski

Pilch

et al. 2018

The aim of the work was to compare the degradation behavior of electrospun nanofibres obtained from pure poly(lactic acid) (PLA) and modified with carbon nanotubes (CNTs) in aqueous environment. The nanofibres in the form of mats were manufactured using the electrospinning technique (ES) with potential biomedical application. To investigate the degradation behavior, onecomponent and composite (containing CNTs) nanofibres were compared using scanning electron microscopy (SEM), water contact angle measurements, differential scanning calorimetry (DSC), and mechanical testing. The changes in their morphology, structure, and selected physical and mechanical properties during incubation up to 14 days were analysed. Two types of CNTs differing in concentration of surface functional groups were used to modify the PLA nanofibres. PLA and composite nanofibres (PLA + CNT) during incubation underwent swelling and partial degradation due to the penetration of water into polymer matrix. Changes in the mechanical properties of composite mats were higher than those observed for pure PLA mats. After 14-day incubation, samples retained from 47 to 78% of their initial tensile strength, higher for PLA samples. Morphological changes in pure PLA nanofibres were more dynamic than in composite nanofibres. No significant changes in crystallinity, wettability, and porosity of the samples occurred.

“…Since the polymer matrix is the same in all cases, this result can be reasonably ascribed to the higher porosity of both the TIPS and ES membranes with respect to the DIPS membranes. In fact, porosity allows the material to entrap air when the surface is immersed in water, thus enhancing the hydrophobicity of the PLA membranes [19]. At the same time, m-ES and m-TIPS membranes showed the highest WCA reduction, i.e.…”

Section: Sem Images Of (A) Es Membrane; (B) Tips Membrane; (C) Front mentioning

confidence: 97%

“…Differently, in acid medium (pH 1) PLA molecular chains change their character from hydrophobic to hydrophilic thus allowing PLA swelling and the bulk degradation of the samples [19]. In both cases, during PLA degradation, lactic acid oligomers, lactide and lactic acid are formed [38].…”

Section: Comparative Study On Pla Membranes Degradation At Extreme Phmentioning

confidence: 99%

“…On the other hand, electrospinning produces ultrafine fibers ranging from micro-to nano-meter in diameters from polymeric solutions or melts [19]. Electrospun (ES) membranes show high porosity and, tunable mechanical properties as well as high surface to volume ratio due to their small fiber dimension and they were successfully integrated in microfluidic chips for cell culture or for immunoassay optimization [20][21][22][23].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Engineered membranes for residual cell trapping on microfluidic blood plasma separation systems. A comparison between porous and nanofibrous membranes

Lopresti

Keraite

Ongaro

et al. 2020

Preprint

Self Cite

Blood-based clinical diagnostics require challenging limit-of-detection for low abundance, circulating molecules in plasma. Micro-scale blood plasma separation (BPS) has achieved remarkable results in terms of plasma yield or purity, but rarely achieving both at the same time.Here, we proposed the first use of electrospun polylactic-acid (PLA) membranes as filters to remove residual cell population from continuous hydrodynamic-BPS devices. The membranes hydrophilicity was improved by adopting a wet chemistry approach via surface aminolysis as demonstrated through Fourier Transform Infrared Spectroscopy and Water Contact Angle analysis.The usability of PLA-membranes was assessed through degradation measurements at extreme pH values. Plasma purity and hemolysis were evaluated on plasma samples with residual red blood cell content (1, 3, 5% hematocrit) corresponding to output from existing hydrodynamic BPS systems.Commercially available membranes for BPS were used as benchmark. Results highlighted that the electrospun membranes are suitable for downstream residual cell removal from blood, permitting the collection of up to 2 mL of pure and low-hemolyzed plasma. Fluorometric DNA quantification revealed that electrospun membranes did not significantly affect the concentration of circulating DNA. PLA-based electrospun membranes can be combined with hydrodynamic BPS in order to achieve high volume plasma separation at over 99% plasma purity.