Preparation, characterization and in vitro release study of drug-loaded sodium carboxy-methylcellulose/chitosan composite sponge

Abstract

A sodium carboxy-methylcellulose (CMC)/chitosan (CS) composite sponge as drug carrier was prepared, and its structure and functions were investigated. Samples with different CMC/chitosan ratios and under different pH conditions were synthesized via a freeze-drying method. The microstructure of the dried sponges was analyzed by Scanning Electron Microscope (SEM). Molecule interactions between polymers were confirmed by Fourier transform infrared (FTIR) spectra and Thermal gravimetric analyze (TGA). The swelling degree, weight loss, in vitro drug release behavior and antibacterial property of the sponges were determined as well. The results showed that the CMC/chitosan ratio and the pH value significantly affected the appearance of the blending solution and the microstructure of the final product, and also affected the sponge’s degradation behavior, drug-loading capacity and the antibacterial activity. Gentamicin (GEN) as a hydrophilic model drug was remarkably superior to the other two hydrophobic drugs, ibuprofen (IBU) and roxithromycin (ROX), with respect to in vitro releasing. Moreover, higher CMC content and lower pH value of the sponge were confirmed to lead a larger loading for GEN. The bacteriostatic experiment showed a strong antimicrobial ability of GEN-loaded sponges on inhibiting Escherichia coli.

Synthesized nano particles of glimepiride via spray freezing into cryogenic liquid: characterization, antidiabetic activity, and bioavailability

“…The other factor that plays a major role in solubility enhancement is the nanosize, porous, and amorphous structure of GP in GPNs formulations; that give a large surface area available for dissolution in addition to the high internal energy of the amorphous state compared to the crystalline state that led to a faster dissolution rate. The reverse relationship between the dissolution rate and the particle size was verified by many studies, which deliberated the relation between the particle size and the solubility of poorly soluble drugs (Soni et al., 2017 ; Cai et al., 2018 ). At the same time, the greater wettability increased the dissolution rate of the SFCL nanosized powder (Chaudhari et al., 2012 ).…”

Dendrobium officinale Enzyme Changing the Structure and Behaviors of Chitosan/γ-poly(glutamic acid) Hydrogel for Potential Skin Care

“…As reported, the degradation process of macromolecules such as polysaccharides, in general, goes through the following steps: dehydration, depolymerization and the decomposition [ 52 , 53 ]. The initial mass loss below 200 °C mainly results from the removal of free water [ 54 ], the loss at 275 °C–350 °C the random cleavage of glycosidic bonds [ 55 ], and the loss at 300–600 °C the decomposition of the saccharide ring structure [ 56 ]. Relative to covalent crosslinking, noncovalent crosslinking can be easier broken at around 300 °C.…”

Formulation of Microwave-Assisted Natural-Synthetic Polymer Composite Film and Its Physicochemical Characterization

“…In case of untreated polymeric films (Figure 3(a)), the moisture uptake capacity of the films decreases with an increase in the Na-CMC contents, but no significant difference among the samples was observed (ANOVA, p > 0:05). Despite being a hydrophilic polymer, an increase in Na-CMC content provides more polymer for cross-linking with Eudragit moiety leading to formation of denser composite matrix which hindered the water penetration ability into it [32,78,89]. In case of microwave-treated samples, a significant fall in water uptake capacity of the film was observed for both time treatments: i.e., 60 s and 120 s, for F2 formulation while F1 remained almost unaffected (ANOVA, p < 0:05, Figure 3(b)).…”