Preparation, characterization, and potential application of chitosan, chitosan derivatives, and chitosan metal nanoparticles in pharmaceutical drug delivery

Ahmed, Tarek A.; Aljaeid, Bader M

doi:10.2147/dddt.s99651

Cited by 559 publications

(291 citation statements)

References 214 publications

(225 reference statements)

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“…The zeta potential of the chosen ES-NPs was À36.34 ± 0.16 mV, suggesting that the delivery system was stable (Ahmed & Aljaeid, 2016). As ES is a 20 kDa peptide, the encapsulation of ES into NPs is difficult, but we observed a high encapsulation rate in the ES-loaded CS NPs at 74.81%±4.23%.…”

Section: Resultsmentioning

confidence: 69%

Preparation of endostatin-loaded chitosan nanoparticles and evaluation of the antitumor effect of such nanoparticles on the Lewis lung cancer model

Ding

Xie

et al. 2017

Drug Delivery

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The purpose of this study was to prepare ES-loaded chitosan nanoparticles (ES-NPs) and evaluate the antitumor effect of these particles on the Lewis lung cancer model. ES-NPs were prepared by a simple ionic cross-linking method. The characterization of the ES-NPs, including size distribution, zeta potential, loading efficiency and encapsulation efficiency (EE), was performed. An in vitro release test was also used to determine the release behavior of the ES-NPs. Cell viability and cell migration were assayed to detect the in vitro antiangiogenic effect of ES-NPs. In order to clarify the antitumor effect of ES-NPs in vivo, the Lewis lung cancer model was used. ES-NPs were successfully synthesized and shown to have a suitable size distribution and high EE. The nanoparticles were spherical and homogeneous in shape and exhibited an ideal releasing profile in vitro. Moreover, ES-NPs significantly inhibited the proliferation and migration of human umbilical vascular endothelial cells (HUVECs). The in vivo antiangiogenic activity was evaluated by ELISA and immunohistochemistry analyses, which revealed that ES-NPs had a stronger antiangiogenic effect for reinforced anticancer activity. Indeed, even the treatment cycle in which ES-NPs were injected every seven days, showed stronger antitumor effect than the free ES injected for 14 consecutive days. Our study confirmed that the CS nanoparticle is a feasible carrier for endostatin to be used in the treatment of lung cancer.

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Section: Resultsmentioning

confidence: 69%

Preparation of endostatin-loaded chitosan nanoparticles and evaluation of the antitumor effect of such nanoparticles on the Lewis lung cancer model

Ding

Xie

et al. 2017

Drug Delivery

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“…The higher the degree of zeta potential, the more the stability of particles. This result shows that the increasing of chitosan concentration creates a stability of PLGA-CS MPs in solution [26].…”

Section: Resultsmentioning

confidence: 62%

Fabrication of Core-Shell PLGA-Chitosan Microparticles Using Electrospinning: Effects of Polymer Concentration

Hiệp

Hai

Toi

2017

International Journal of Polymer Science

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This investigation aims to fabricate the core-shell microparticles composed of poly(lactic-co-glycolic acid) and chitosan (PLGA-CS MPs) using electrospinning. The challenge of using electrospinning is that it has many parameters which change product outcome if any single parameter is changed. However, the advantage of this system is that we can fabricate either micro/nanofibers or micro/nanoparticles. To learn about the effect of liquid concentration, the electrospinning parameters (voltage, needle sizes, distance from needle to collector, and ejection speed) were fixed while the concentration of PLGA or chitosan was varied. The results showed that PLGA microparticles can be fabricated successfully when the concentration of PLGA is smaller than 10 wt%. Presence of the chitosan shell was confirmed by zeta potential measurements, FT-IR, optical observation, and fluorescence observation. Thickness of the chitosan shell can be controlled by changing the concentration of chitosan and measured by fluorescamine labeling method. Moreover, SEM observation showed that concentration of chitosan affected the size of PLGA-CS microparticles. The MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide) assay test showed that PLGA-CS microparticles possess excellent biocompatibility.

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“…The modification of chitosan nanoparticle has received much attention in relation to their potential application, especially from a pharmaceutical viewpoint. 13,14 Nanoparticle chitosan has gained growing interest due to its biocompatibility, biodegradability, high permeability, cost-effectiveness, non-toxic property and excellent film forming ability. Moreover, its ability to enhance the penetration of large molecules across a mucosal surface and its recognition as muco adhesivity chitosan.…”

Section: Scanning Electron Microscopic (Sem) Studies Of Chitosan Nanomentioning

confidence: 99%

In vitro Antibacterial Activity of Chitosan Nanoparticles against Mycobacterium tuberculosis

Sudjarwo¹,

Mahmiah²,

Sudjarwo³

2017

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Background:Chitosan nanoparticles have gained growing interest for nanomedicine, biomedical engineering and development of new therapeutic with improved bioavailability, increased sensitivity and specificity, and reduced toxicity. Objective: The aim of the present study is to synthesis of the chitosan nanoparticles for antimycobacterial applications. Methods: Chitosan were isolated from the shrimp shell. Tripolyphosphate (TPP) will be used to prepare chitosan nanoparticles by ionotropic gelation method. The size and morphology of the chitosan nanoparticle was analyzed by scanning electron microscope (SEM). The broth microdilution method is used to determine the minimal inhibitory concentration (MIC) and minimal bactericidal concentration (MBC) of nanoparticle chitosan on strain M. tuberculosis H37Rv. Results: The SEM micrographs of the nano-magnetic chitosan showed that they were approximately uniform spheres and the rough surface morphology, have a solid dense cubical or rectangular structure. Using the broth microdilution susceptibility method, chitosan nanoparticle was found to have the antimycobacterial effects with a MIC value of 1200 μg/mL whilst MBCs value of 2400 μg/mL for M. tuberculosis H37Rv. Conclusion: The conclusion from the study was chitosan nanoparticle have potential as a source of lead compounds that may be developed further into antimycobacterial drugs.

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Preparation, characterization, and potential application of chitosan, chitosan derivatives, and chitosan metal nanoparticles in pharmaceutical drug delivery

Cited by 559 publications

References 214 publications

Preparation of endostatin-loaded chitosan nanoparticles and evaluation of the antitumor effect of such nanoparticles on the Lewis lung cancer model

Preparation of endostatin-loaded chitosan nanoparticles and evaluation of the antitumor effect of such nanoparticles on the Lewis lung cancer model

Fabrication of Core-Shell PLGA-Chitosan Microparticles Using Electrospinning: Effects of Polymer Concentration

In vitro Antibacterial Activity of Chitosan Nanoparticles against Mycobacterium tuberculosis

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