Preparation, Characterization, and Property of Chitosan/Polyethylene Oxide Electrospun Nanofibrous Membrane for Controlled Drug Release

Li, Wei; Luo, Tian; Shi, Yang; Yong-ming, Yang; Huang, Xuexiang; Xing, Kexin; Liu, Lifei; Wang, Mengqin

doi:10.1080/10584587.2014.901124

Cited by 7 publications

(5 citation statements)

References 46 publications

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“…It is clear that the morphology was different with different molar ratio, varying from nanofiber to the introduction of bead, which was mainly accounted for electrical conductivity and surface tension of the Langmuir solution. 12 Table 1 specifies the nanofiber diameter range in relation to Figure 1. It was varied from 140 to 380 nm.…”

Section: Resultsmentioning

confidence: 99%

“…Figure shows the SEM images of electrospun nanofibrous membranes with vesicle solutions of different CTAB/SDBS molar ratio. It is clear that the morphology was different with different molar ratio, varying from nanofiber to the introduction of bead, which was mainly accounted for electrical conductivity and surface tension of the solution . Table specifies the nanofiber diameter range in relation to Figure .…”

Section: Resultsmentioning

confidence: 99%

“…The electrospun nanofibrous drug delivery system can be designed to control the drug release, no matter whether the release mechanism focuses on diffusion alone or diffusion and scaffold degradation simultaneously. 12 This drug delivery system has attracted much attention in the field of cancer clinical therapy in recent decades. 13−17 It is well known that infection and pain are two headaches after surgery, so two or more different drugs should be released from the electrospun nanofibrous drug delivery system at the proper time and in appropriate doses to prevent infections and reduce the patient's pain during cancer treatment.…”

Section: Introductionmentioning

confidence: 99%

“…For instance, the scaffolds produced from electrospun nanofibers have been applied in wound healing or implant in surgery, which offer site speicific delivery of drugs to the body. The electrospun nanofibrous drug delivery system can be designed to control the drug release, no matter whether the release mechanism focuses on diffusion alone or diffusion and scaffold degradation simultaneously . This drug delivery system has attracted much attention in the field of cancer clinical therapy in recent decades. − It is well known that infection and pain are two headaches after surgery, so two or more different drugs should be released from the electrospun nanofibrous drug delivery system at the proper time and in appropriate doses to prevent infections and reduce the patient’s pain during cancer treatment. − Thus, medication combination treatment in clinical practice is common and useful in order to improve the cancer therapeutic value of medicinal drugs. − Furthermore, high and durable drug content along with low toxicity in situ is supposed to be taken into account as an effective therapy.…”

Section: Introductionmentioning

confidence: 99%

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Formation of Controllable Hydrophilic/Hydrophobic Drug Delivery Systems by Electrospinning of Vesicles

Luo

Yong-ming

et al. 2015

Langmuir

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Novel multifunctional poly(ethylene oxide) (PEO) nanofibrous membrane, which contains vesicles constructed by mixed surfactant cetyltrimethylammonium bromide (CTAB)/sodium dodecylbenzenesulfonate (SDBS), has been designed as dual drug-delivery system and fabricated via the electrospinning process. 5-FU and paeonolum, which are hydrophilic and hydrophobic anticancer model drugs, can be dissolved in vesicle solution's bond water and lipid bilayer membranes, respectively. The physicochemical properties of the electrospun nanofibrous membrane were systematically studied using scanning electron microscopy (SEM), transmission electron microscopy (TEM), Fourier transform infrared (FTIR), and X-ray diffraction (XRD). Drug release behaviors of the electrospun nanofibrous membrane fabricated with different molar ratio of CTAB/SDBS vesicle solution were investigated. The result showed that the releasing amount of hydrophilic drug presented an ascending release manner, while the hydrophobic one showed a descending release behavior with increasing of the molar ratio of CTAB/SDBS. Moreover, the release amount of drugs from drug delivery system can be controlled by the molar ratio of CTAB/SDBS in the vesicle solution easily and conveniently. The distinct properties can be utilized to encapsulate environmental demanding and quantificational materials.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Formation of Controllable Hydrophilic/Hydrophobic Drug Delivery Systems by Electrospinning of Vesicles

Luo

Yong-ming

et al. 2015

Langmuir

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“…[126,[128][129][130] By electrospinning a blend of poly(ethylene oxide) (PEO) and chitosan, W. Li et al produced pH-responsive nanofibers allowing a controlled release of 5-fluorouracil, an anticancer drug. [131] The addition of PEO to the polymer solution allowed a reduction of the repulsive forces between the polycationic chitosan chains, thus, leading to favored chain entanglement and the formation of nanofibers. The measured release rate of the drug did not indicate a burst release but a sustained release, which proved to be faster when switching the pH from 7.4 to 5.4.…”

Section: Natural Polymersmentioning

confidence: 99%

pH-Responsive Electrospun Nanofibers and Their Applications

et al. 2021

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Electrospun nanofibrous membranes offer superior properties over other polymeric membranes not only due to their high membrane porosity but also due to their high surface-to-volume ratio. A plethora of available polymers and post-modification methods allow the incorporation of "smart" responsiveness in fiber membranes. The pHresponsive property is achieved using polymers from the class of polyelectrolytes, which contain pH-dependent functional groups on their polymeric backbone. Electrospinning macroscopic membranes using polyelectrolytes earned considerable interest for biomedical and environmental applications due to the possibility to trigger chemical and physical changes of the membrane (swelling, wettability, degradation) in response to environmental pH-changes. Here, we review recent advancements in the field of electrospinning of pHresponsive nanofiber materials. Starting with the chemical background of pH-responsive polymers at the molecular level, we highlight the material-property transformation upon pH-change at the macroscopic membrane level and, finally, we provide an overview of recent applications of pH-responsive fiber membranes.

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Broad Scale and Structure Fabrication of Healthcare Materials for Drug and Emerging Therapies via Electrohydrodynamic Techniques

Mehta

Zaman

Smith

et al. 2018

Advanced Therapeutics

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The engineering of advanced healthcare materials provides a platform to address challenges facing interdisciplinary scientists, clinicians, pharmacists, biomaterial scientists, and biomedical engineers. Niche, timely developments arising from the synthesis or extraction of more biocompatible materials, new biologically active components, clearer insights into disease mechanisms, and novel therapies provide several timely opportunities. These include enhanced therapies with greater patient compliance, improved disease targeting, better diagnosis, and bespoke medications for individuals. Electrohydrodynamic atomization (EHDA) comprises several processes making use of electric fields interplaying with several forces. Coupled to advanced materials and specifically configured apparatuses, effective and controlled fabrication of various structures on various scales possessing various dimensions is readily achieved. The processes have distinct advantages compared to established engineering methods (ambient environment engineering, low shear, scalability, compartmentalization, etc.). This detailed review focuses on key concepts and developments in EHDA engineering pertaining to underlying principles, enabling tools and engineered structures specifically for healthcare remits. From initial experiments involving the behaviour of non‐formulated liquids on charged amber to recent developments in complex 3D matrix printing, the EHDA route has progressed significantly in the last two decades, and is capable of providing timely platform opportunities to tackle several global healthcare challenges.

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Preparation, Characterization, and Property of Chitosan/Polyethylene Oxide Electrospun Nanofibrous Membrane for Controlled Drug Release

Cited by 7 publications

References 46 publications

Formation of Controllable Hydrophilic/Hydrophobic Drug Delivery Systems by Electrospinning of Vesicles

Formation of Controllable Hydrophilic/Hydrophobic Drug Delivery Systems by Electrospinning of Vesicles

pH-Responsive Electrospun Nanofibers and Their Applications

Broad Scale and Structure Fabrication of Healthcare Materials for Drug and Emerging Therapies via Electrohydrodynamic Techniques

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