Preparation, Characterization, Biological Evaluation and Assess Laser Efficacy for New Derivatives of Imidazolidin-4-one

Abstract

In this study, new Imidazolidin-4-one [A1-A5] compounds were prepared by the reaction of schiff base compounds with alanine in ethanol. The prepared compounds were characterized by physical properties, UV-Vis, FT-IR and 1H-NMR spectral and C.H.N analysis. TLC checked the purity for these compounds. All compounds [A1-A5] were prepared by the traditional method (reflux) and microwave technology. It was found that using the microwave method gives better results in terms of less time and, higher yield. Antibacterial behaviors were investigated against a variety of bacteria, including Escherichia coli and Klebsiella pneumonia Gram (-) ve, Staphylococcus aureus, and Staphylococcus epidermidis Gram (+) ve. The laser efficacy of the compounds [A1-A5] was evaluated after they were radiated by laser for (10, 20, 30) seconds. As the melting point and color of the substances were determined, it was discovered that they were unaffected and did not disintegrate or polymerize. Using the Chem Draw Specialist 19.0 program, the stereoisomers of the prepared compounds [A1-A5] were examined at the lowest layer stage. Using the Chem3D 19.0 program, the heat of the formulation of the compounds [A1-A5] was also investigated.

Determination of cefdinir in pharmaceutical preparations by oxidative conjugation method

“…Effect of oxidation time: The time at which the drug is oxidized using the oxidizing agent NBS was studied, and before completing the rest of the additions and completing the volume in the volumetric vial, and the results are shown in Table (8), depending on the same optimal conditions, where the time 10 minutes was sufficient to complete the oxidation process. Calibration curve: The calibration curve for (Cef) pure form with 2,4 Dipyridin showed the linearity at concentration rang of (2-60) µg/ml, as shown in figure (12). Application of the proposed method: In table (10), the result of determination of (Cef) in the pharmaceutical preparations (as tablets).…”

“…Determination of (Cef) by P-aminobenzoicacid: The optimum conditions were reached after conducting an initial test, as 1ml of the oxidizing agent with a concentration of 0.001M was added to 5ml of cefdinir at a concentration of 250 mg/ml in a 10ml capacity, then 1ml of the reagent at a concentration of 0.01M was added, then followed add 0.5 ml of sodium hydroxide at a concentration of 1M, then supplement the volume with distilled water to the mark and the maximum absorption of the product is 0.589 at laboratory temperature at 467 nm versus its photo solution, while the photo solution did not give any absorption in this region [12][13][14][15], as in figure (2): Application of proposed methods: The proposed approach was utilized to calculate Cef in a pharmaceutical tablet formulation. Ten tablets weighed 6.2030 g and were finely pulverized till they were turned into a fine powder.…”

Synthesis, characterization of ‎2-amino-pyran ‎and derivatives evaluation of the bacterial, ‎antioxidant and anticancer activity

“…It is clear from the collected data that the free radical scavenging activity of the compound under search increased with increasing concentration exhibiting; for that, the highest free radical scavenging percentage is given with 200 µg\mL of with 80 %, and had the lowest percentage of 40% when 25 µg\mL. Also, this search displays that 2-amino-pyran derivatives were a leading source of anti-oxidant, besides it has an excellent free radical scavenging activity and functions as an anti-bacterial [37,38]. As shown in figure (6).…”

Preparation and characterization of new compounds for schiff base derived from furfural, study of some physical applications and evaluation of their biological activity

“…Electrical conductivity is widely used in coordination chemistry; This is to know the ionic formulas that can be obtained in the compound, whether a solid or a solution. The degree of conductivity increases as the number of ions liberated in the solution increases, while the degree of conductivity in the complex that does not ionize is low [26].…”