Preparation, Characterization of Some Metal Complexes of New Mixed Ligands Derived from 5-Methyl Imidazole and Study the Biological Activity of Palladium (II) Complex as Anticance

Abstract

A new series of mixed ligand complexes synthesized and characterized using of azo ligand derived from (5-methyl— imidazole) with (8-hydroxy quinolone). New mix-ligand structures and their transitional metal complexes were fully characterized using several techniques, including molar conductance, elemental analysis (C.H.N), electronic spectral, magnetic measurements, 1HNMR, spectral studies, and mass spectra. The data shows that these complexes have a composition of [ML(8-HQ) Cl2] H2O where M = Co(II), Zn(II), Cu(II), X=0, and Ni(II), X=1, [ML(8-HQ)] Cl. where M=Pd. The electronic spectral data and magnetic susceptibility calculations of the complexes indicate that the octahedral geometry of all complexes, except for the Pd(II) complex, indicates a planar-square geometry. The results demonstrate that the nitrogen of the imidazole ring and azo nitrogen atom of the primary ligand are coordination sites with a nitrogen atom and oxygen atom of a secondary ligand of the (8-HQ) in the basic medium. Biological effects of the palladium (II) complex are screening against human breast cancer (MCF-7 and AMJ-13) and normal cells (HBL) were examined, which indicated colon cancer cell line LS-174. The results show the highest activity effect for the complex.

Exploring the Anticancer Activity of Gold Complex with Newly Ligand (DDIBM): Synthesis, Spectral Identification and Magnetic Susceptibility of Its Metallic Complexes

“…The ligand spectrum of the ligand was compared with the Co(II) complex spectrum, which showed two absorption peaks, the first at 502 nm (19920.318 cm −1 ) due to the electron transition 4 T 1 g(F)→ 4 T 1 g(P)=(ν 3 ) and an absorption peak at 688 nm (14534.883 cm −1 ) has been attributed to the electron transition 4 T 1 g(F)→ 4 A 2 g(F)=(ν 2 ). This fact is consistent with the literature on the appearance of this band in octahedral Co(II) complexes [41]. The UV-vis spectrum of Ni(II) complex solution recorded an absorption peak at 496 nm (20161.290 cm −1 ) due to the electron transition 3 A 2 g→ 3 T 1 g(F)=(ν 2 ) and this is consistent with what was mentioned in the literature regarding octahedral Ni(II) complexes [41].…”

“…This fact is consistent with the literature on the appearance of this band in octahedral Co(II) complexes [41]. The UV-vis spectrum of Ni(II) complex solution recorded an absorption peak at 496 nm (20161.290 cm −1 ) due to the electron transition 3 A 2 g→ 3 T 1 g(F)=(ν 2 ) and this is consistent with what was mentioned in the literature regarding octahedral Ni(II) complexes [41]. The UV-vis spectrum of Cu(II) complex solution showed a broad absorption peak at 471 nm (21231.422 cm −1 ) due to the electron transition ( 2 Eg→ 2 T 2 g), and this is consistent with what was mentioned in the literature [42].…”

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“…containe 4-bromo-2-chloro phenol (2.07 g, 0.01 mL) and (10% NaOH in 50 mL ethanol) with constant stirring at 0.0-5.0 °C and allowed to stand overnight and acidified with dilute HCl to pH=6., orange-red colored solution, Darkness is observed. The crystals were filtered off, washed with D.W and purified by recrystallization from hot ethanol and dried at room temperature [9]. The structural of the ligand (BIABrClP) was shown in Scheme 1.…”

Synthesis, Chemical Characterization, and Bacterial Inhibition Studying of New Mixed Ligand Complexes of 4-Methylimidazoleazo Ligand, and Ethylenediamine with Some Divalent Metal Ions

“…spectrum of primary (TBPAM) ligand exhibited two peaks at (214) and (268) nm due to (π-π*) of aromatic rings, There is no noticeable changes of their positions in the complexes spectra, but there is a red shift of (n-π*), and (ILCT) transitions at (368, 380) nm respectively in the complexes spectra due to the participation of this primary ligand in the coordination, as explained in table 2. ------------------------- FT-IR spectra measurements of purified solid complexes revealed a small significant changes in position and intensity for v(N-H) of imidazole ring at (3420) cmin the primary (TBPAM) ligand , and v(N-H) of amine group in the secondary (en) ligand at (3441) ,and (3385) cm -, while there was noticeable shifting to the higher frequencies of v(C=N) and v(C-N) which belongs to the imidazole ring in (TBPAM) ligand at (1577) cmand (1374) cm - [14,15] due to the participation of (N3) atom in the coordination , while the frequencies of v(-N=N-) at (1428) cm - [16,17] has shifted to the higher values as a result of coordination through one nitrogen atom of azo functional group, also there was observable shifting of v(C-N) of C-C-NH2 and v(C-C-NH2) for ethylenediamine at (1403) cm -, and (1567) cmrespectively [18] to the lower frequencies as a result of coordination of this secondary ligand through nitrogen atom of terminal (-NH2) group, the complexes spectra also distinct new peaks between (420 -437) cmdue to v(M-N) [19][20][21] frequencies bond after the coordination between both of primary and secondary ligands , as shown in the table (3), and figures (4-6). The calculated percentage values of (C.H.N) elements and metal ions in the complexes were found to be in good agreement with their measured values, confirming the chemical formulae of the synthesized compounds, and their purity as shown in table 1.…”

“…In the recent years, the researchers interesting focus on preparation and characterization of mix ligand complexes with different transition metal ions in different oxidation state which have more than one coordination position and have multiple types of ligands [1,2], which effects on the stability of the prepared compounds and exploiting their properties in various applications especially the antibacterial activity [3][4][5][6].…”