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New imidazole  azo ligand (DPIDA) was prepared by coupling reaction between 4,5-di phenyl imidazole and N1,N1-dimethylbenzene1,4-diamine di hydrochloride  and studied the complexation of this ligand with Mn(II) , Co(II) , Ni(II) , Cu(II) , Zn(II) , Cd(II) , and Hg(II)  ions , The free ligand and it’s complexes  characterized by Mass, 1HNMR, IR, UV-Vis. ,  and molar conductivity that indicated the octahedral geometry of them with a bidentate ligand which coordinated from (N3) atom of imidazole ring and one nitrogen atom of azo group.Biological activity of ligand (DPIDA) and it's complexes tested against two multi-drug resistant aerobic pathogenic bacteria isolated from patients with a burn. Three concentrations were selected (50, 100, 150) mg/ml for each crud synthesized derivative compounds. The derivative compound (4,5-diphenyl imidazole) with concentration 150mg/ml had an excellent antibacterial effect against Staphylococcus aureus and Pseudomonas aeruginosa with inhibition zone 21.83 ± 0.1764 mm and 24.30 ± 0.4163 mm respectively.

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New synthesized series of mixed ligand complex prepared for Co (II), Ni (II), Cu (II), Cd (II), and Hg (II) ions, with azo compound derived from 4-methylimidazole as a primary ligand (TBPAM) , and ethylene diamine as a secondary ligand. Mass , 1HNMR, C.H.N, Uv-Vis, FT-IR, Atomic Absorption, Molar Conductivity, and Magnetic Susceptibility techniques were used to characterize the complexes, the results were indicated the octahedral geometry with a general formula [M(TBPAM)(en) Cl2] for all complexes, where primary and secondary ligands behaved as a bidentate, finally a noticeable bacterial inhibition of the complexes and primary ligand at a concentration (100mg/ml) was appeared against complexes against Klebsiella, P.aeruginosa, and S. aureus bacteria Keywords: Mixed ligand; Complexes, Biological investigation; imidazole; ethylenediamine.

Heterocyclic azo compound 2-(8-quinolyl azo)-4,6-dimethyl phenol as a primary ligand and imidazole molecule as a secondary ligand in the basic medium were prepared with novel mixed ligand complexes of Hg(II), Mn(II), Ni(II), Co(II) and Cu(II) ions, these compounds were characterized by Mass, 1HNMR, IR, UV-Vis, Magnetic susbtibility and Molar Conductivity, which suggested octahedral conductivity. Free ligands and five mixed ligand complexes of Hg(II), Mn(II), Ni(II), Co(II) and Cu(II) metal ions with a general formula of [M(L1)(L2)2C1] against eight pathogenic multidrug resistance bacteria, six G-ve bacteria (Pr. mirabilis, S. typhi, E. coli, P. aeroginosa, A. baumanii and K. pneumoniae) and two G+ve bacteria (E. faecalis and S. aureus) were capable of antimicrobial efficacy. The findings show that free ligands have had stronger antibacterial activity on S. Bacterial isolation of typhi and P. aeroginosa relative to other isolates. As for the effectiveness of metal complexes, compared to G+ve bacteria, they usually have a large antibacterial effect on G-ve bacteria, whereas the Hg(II) ion complex has a higher antibacterial effect on most bacterial isolates compared to other metal complexes. Compared with other metal complexes, Mn (II) ion complexes demonstrated poorer antibacterial activity..