This work involves preparation of a series of 1,2,3-triazole derivatives. In the first step, the reaction of N-acetyl-5H-dibenzo [b,f] carboxamide with different benzaldehyde derivatives to yield chalcone compounds A-D was carried out. In the second step, compounds A-D reacted with 4,4' sulfonylbis(azidobenzene) (G) to produce 1,2,3-triazole derivatives A 1 -D 1 . All the prepared compounds were characterized by Fourier-transform infrared spectroscopy (FTIR) and melting point, some of them were characterized by proton nuclear magnetic resonance ( 1 H-NMR), spectroscopy analysis. Biological activity test was done to evaluate the antibacterial activity of eight synthesized derivative compounds against two multi-drug resistant pathogenic bacteria isolated from patients infected with burn infection; Staphylococcus aureus and Pseudomonas aeruginosa. Three concentrations were selected 50, 100 and 150 mg/mL from each of the synthesized derivative compounds. The derivative compound D 1 with the concentrations of 100 and 150 mg/mL exhibited excellent effect against P. aeruginoa with inhibition zone diameters of 28.10 ± 0.5 and 28 ± 0.05 mm, respectively.

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Preparation of Schiff bases compounds (A, B, and C) in absolute ethanol using concentrated phenyl hydrazine and various aromatic aldehydes such as (4-chlrobenzaldehyde aldehyde, 4-bromobenzaldehyde, N, N-dimethyl amino benzaldehyde). Melting point, FT, has been used to classify these compounds (A, B, and C). The reactions phases and series were studied using IR spectroscopy and thin layer chromatography (TLC) (ethyl acetate: toluene, 1:4). Three derivate compounds were used as antibacterial activity in this study. The results proved that all derivative compounds provided good inhibition zone against Staphylococcus aureus and pseudomonas aeruginosa especially in concentration 300mg/ml of derivative compound C with diameter inhibition zone 21.433±0.676 and 625.33±0.796 respectively.

This study includes formation Schiff bases compounds [A1- A3] were synthesis from raction4-aminoantipyrine with many aromatic aldehydes [4- chloro benzaldehyde, 4-bromo benzaldehyde and 2-hydroxy1-naphthaldehyde] in absolute ethanol. These compounds [A1-A3] has been characterized by melting points, [FT.IR] spectroscopy, thin layer chromatography technique (TLC) has been used for reactions steps and sequence by using solvent (ethyl acetate:toluene, 1:4). Antibacterial activity test was done according to agar well diffusion method against two types of multi-drug resistance of bacteria isolated from patients with infection of urinary tract. Three concentrations were prepared for each compound (50, 100 and 150) mg/ml. The results proved that derivative compound A3150 mg/ml provided the best antibacterial activity against K.pneumoniae with inhibition zone diameter 21± 0.25mm and against C.freundii 22± 0.5mm as compared with other derivatives compounds.