Preparation, Evaluation and Characterization of Rutin–Chitooligosaccharide Complex

Nanoparticles Based on Chondroitin Sulfate from Tuna Heads and Chitooligosaccharides for Enhanced Water Solubility and Sustained Release of Curcumin

“…Based on the obtained results, the CH:CS ratio of 3:2 was chosen as the optimal ratio for nanoparticle preparation according to the low PDI and high magnitude of zeta potential values, resulting in a greater stability of CU nanoparticles [ 45 ]. The current study confirmed the findings about the CH’s ability to enhance the water solubility of poorly water-soluble drugs such as hesperidin [ 55 ], rutin [ 56 ], naringin [ 54 ], β-carotene [ 57 ], and silymarin [ 85 ], as well as CS that could form polyelectrolyte complexes through an electrostatic interaction with positively charged CH, thus providing an optimal strategy to maintain CS in the solid state for use as a drug-delivery system [ 45 ].…”

“…While chitosan has been regarded as more popular in nano-carrier preparation due to its high molecular weight and viscosity [ 43 , 51 , 52 , 53 ], CH has been considered to possess higher bioactive activities such as antioxidant, anti-inflammatory, and immunomodulatory activities due to its water solubility and absorbability [ 49 , 54 , 55 ]. As a result, CH has gained much attention for its novel applications in nanoformulation to enhance the water solubility of poorly water-soluble drugs [ 54 , 55 , 56 , 57 ]. CS copolymer with chitosan has been proven as an efficient delivery system for curcumin (CU) [ 44 , 45 ]; however as far as we know, no previous research has investigated its copolymer with CH.…”

Preparation, investigation and storage application of thymol–chitooligosaccharide complex with enhanced antioxidant and antibacterial properties

“…The results were calculated as μmol L −1 TE per gram of sample by a calibration curve of Trolox (0–1000 μmol L −1 ). Ferric reducing antioxidant power (FRAP) was determined by a previous method, 11 calculated as μmol L −1 TE per gram of sample using a calibration curve of Trolox (0–1000 μmol L −1 ). The sample concentration was 2 mg mL −1 .…”

“…COS, degraded from chitosan, has much smaller molecular weight, excellent biocompatibility and biodegradability, and can be easily absorbed by the intestine into the circulation 7,9 . Thus COS has been widely used to interact with polyphenols such as hesperidin and rutin in order to improve their physical and biological properties 10,11 . Tripolyphosphate (TPP), a non‐toxic crosslinking agent, has negatively charged phosphate groups and can induce spontaneous gelling ability of COS, as well as benefits the formation of a COS crosslinked network.…”

“…7,9 Thus COS has been widely used to interact with polyphenols such as hesperidin and rutin in order to improve their physical and biological properties. 10,11 Tripolyphosphate (TPP), a non-toxic crosslinking agent, has negatively charged phosphate groups and can induce spontaneous gelling ability of COS, as well as benefits the formation of a COS crosslinked network. Thus, it is hypothesized that through appropriate crosslinking with TPP, COS could also affect Thy retention and promote its use.…”