Preparation, Investigation and Enzymatic Activity of Mixed Iigand Complexes of Mefenamic Acid and Phenyl Alanine with some Transition Metal

Khamis, Wessal M.; Abbas, Bayader F.; Abdulsada, Shaemaa Hadi; Mohammed, Mustafa Taha; Sultan, Alaa A.; Khamis, Nedhal M.

doi:10.36478/jeasci.2019.734.743

J. Eng. Appl. Sci.

2019

DOI: 10.36478/jeasci.2019.734.743

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Preparation, Investigation and Enzymatic Activity of Mixed Iigand Complexes of Mefenamic Acid and Phenyl Alanine with some Transition Metal

Wessal M. Khamis¹,

Bayader F. Abbas²,

Shaemaa Hadi Abdulsada³

et al.

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Synthesis, Characterization, and Antimicrobial Evaluation of Schiff Base-mixed Ligand Complexes with Divalent Metal Ions Derived from Amoxicillin and Vanillin/Nicotinamide

Bahry,

Al-Noor,

Fardous

et al. 2024

CPD

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Introduction: This study focuses on the development of novel antimicrobial agents. A Schiff base ligand, 6-(2-(4-hydroxy-3-methoxybenzylideneamino)-2-(4-hydroxyphenyl)acetamido)-3,3-dimethyl-7-oxo- 4-thia-1-azabicyclo [3.2.0] heptane-2-carboxylic acid, synthesized through the condensation of amoxicillin and vanillin in methanol, served as the foundation. Polydentate mixed ligand complexes were then formed by reacting the Schiff base with metal ions (Fe(II), Co(II), Ni(II), Cu(II), and Zn(II)) and nicotinamide in specific ratios. Methods: Characterization involved various techniques, such as 1H-NMR, FT-IR, UV-Vis, and elemental analysis for the ligand, and Atomic Absorption, FT-IR, UV-Vis, magnetic susceptibility, and conductance measurements for the Schiff base-metal ion complexes. Results: Quantum chemical features of both ligands and metal complexes were computed, refining their electronic and molecular structures theoretically. Antimicrobial activity against Staphylococcus aureus, Escherichia coli, Klebsiella pneumoniae, Salmonella typhi, Acinetobacter baumannii, and Pseudomonas aeruginosa was assessed for the starting materials, ligands, and synthesized complexes, revealing significant effects on certain species. In-silico binding modes with Escherichia coli (PDB ID: 5iq9) were determined through molecular docking. Conclusion: This study underscores the potential applications of the Schiff base ligands and their metal complexes in developing new antimicrobial agents.

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Synthesis, Characterization, and Antimicrobial Evaluation of Schiff Base-mixed Ligand Complexes with Divalent Metal Ions Derived from Amoxicillin and Vanillin/Nicotinamide

Bahry,

Al-Noor,

Fardous

et al. 2024

CPD

View full text Add to dashboard Cite

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Synthesis, Characterization and Photo Degradation Studies of New Mixed Ligand Transition Metal Complexes of Mefenamic Acid and Glutamine

Abdullahe

Abbas

Ahmed

et al. 2021

RJPT

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Dentate ligands 2-[(2,3-dimethylphenyl)amino]benzoic acid (Mefenamic acid ) and 2,5-diamino-5-oxopentanoic acid(glutamine) were used as bidentate Lewis base to prepare solid complexes with Molybdenum (V), Tungsten (V)) and Lanthanum(III). The Photo degradation study was achieved for the complexes solutions in methanol. The prepared complexes were characterized by using spectroscopy methods like FTIR, UV-visible, Melting points and flame atomic absorption spectroscopy were calculated for all complexes. Furthermore the molar conductance of 0.001 M solutions in acetonitrile and magnetic susceptibility were performed to elucidate the proposed geometry and structures of prepared complexes. Magnetic susceptibility displayed that complexes had not diamagnetic properties. Photo kinetic study was done for La and Mo Complexes to study the photo sensitivity of prepared complexes. Half time of the complexes` photo reaction were achieved and order of reactions were calculated which appear that photo reaction of LaIII complex was from the first order and constant of reaction was calculated (1.62x10-2) min-1 and half time of reaction was (62.112) min. Also, order reaction of Mo (III) complex was from first order too, the value of constant of reaction was (1.88 min-1) and half time of reaction was (26.6) min. TGA analysis of MoIII was done.

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Preparation, Investigation and Enzymatic Activity of Mixed Iigand Complexes of Mefenamic Acid and Phenyl Alanine with some Transition Metal

Cited by 2 publications

References 0 publications

Synthesis, Characterization, and Antimicrobial Evaluation of Schiff Base-mixed Ligand Complexes with Divalent Metal Ions Derived from Amoxicillin and Vanillin/Nicotinamide

Synthesis, Characterization, and Antimicrobial Evaluation of Schiff Base-mixed Ligand Complexes with Divalent Metal Ions Derived from Amoxicillin and Vanillin/Nicotinamide

Synthesis, Characterization and Photo Degradation Studies of New Mixed Ligand Transition Metal Complexes of Mefenamic Acid and Glutamine

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