Preparation of 2,2-difluoro-1-trialkylsilylethenylstannanes and their cross-coupling reactions

Cross‐Coupling Reactions of (Z)‐2‐Fluoro‐2‐trifluoromethylethenyl Tosylate with Aryl‐ and Arylethenylboronic Acids

“…In our continuing efforts to explore the preparation of trifluoromethylated alkenes, we are interested in the highly stereoselective preparation of trifluoromethylated alkenes by cross‐coupling reaction of the organometallic reagents with the corresponding stereo‐controlled trifluoromethylated alkene. Recently, we established the effective cross‐coupling reactions between several 2,2‐difluoroethenyl tosylate derivatives having two fluorine atoms at the one carbon atom of the double bond and organometallic reagents, in which direct cross‐coupling reaction of tosyl group with arylstannane reagents or arylboronic acids, and transformation of tosyl group to stannane group for the Stille cross‐coupling reactions were described. We will extend this study to the cross‐coupling reaction of trifluoromethylated alkenyl tosylate.…”