Preparation of a biomimetic ECM surface on cardiovascular biomaterials via a novel layer-by-layer decellularization for better biocompatibility

Zou, Dan; Luo, Xiao; Han, Congzhen; Li, Jingan; Yang, Ping; Li, Qian; Huang, Nan

doi:10.1016/j.msec.2018.11.078

Cited by 31 publications

(20 citation statements)

References 53 publications

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“…Recovery of adenosine triphosphate function is beneficial to the operation of sodium pump, which not only contributes to NO release from ECs but also promotes series of factors secretion, including prostaglandin, thrombomodulin, fibronectin, etc 33. The recovery of adenosine triphosphate function depends on Mg ion 26. With the degradation time going on, more elements, such as Zn, Y and Nd were released to the extracts.…”

Section: Resultsmentioning

confidence: 99%

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Effects of degradation products of biomedical magnesium alloys on nitric oxide release from vascular endothelial cells

et al. 2019

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Nitric oxide (NO) released by vascular endothelial cells (VECs), as a functional factor and signal pathway molecule, plays an important role in regulating vasodilation, inhibiting thrombosis, proliferation and inflammation. Therefore, numerous researches have reported the relationship between the NO level in VECs and the cardiovascular biomaterials’ structure/functions. In recent years, biomedical magnesium (Mg) alloys have been widely studied and rapidly developed in the cardiovascular stent field for their biodegradable absorption property. However, influence of the Mg alloys’ degradation products on VEC NO release is still unclear. In this work, Mg-Zn-Y-Nd, an Mg alloy widely applied on the biodegradable stent research, was investigated on the influence of the degradation time, the concentration and reaction time of degradation products on VEC NO release. The data showed that the degradation product concentration and the reaction time of degradation products had positive correlation with NO release, and the degradation time had negative correlation with NO release. All these influencing factors were controlled by the Mg alloy degradation behaviors. It was anticipated that it might make sense for the cardiovascular Mg alloy design aiming at VEC NO release and therapy.

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Section: Resultsmentioning

confidence: 99%

“…As Li et al28 reported that the ECs regulated by the hyaluronic acid micro-strips could release more NO. Thus, in this experiment, NO released from the ECs which were regulated by the hyaluronic acid micro-strips (micro-pattern group) were detected as the positive control 26…”

Section: Methodsmentioning

confidence: 99%

Effects of degradation products of biomedical magnesium alloys on nitric oxide release from vascular endothelial cells

et al. 2019

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“…[149] More recently, they enriched ECM onto the HA micropattern via the layer-by-layer decellularization method. [150] This biomimetic ECM surface exhibited well hemocompatibility and NO release, suggesting high anti-inflammation and rapid endothelialization. Overall, HA patterned surfaces are beneficial for good biocompatibility of cardiovascular devices.…”

Section: Surface Patternsmentioning

confidence: 94%

Surface Engineering of Cardiovascular Devices for Improved Hemocompatibility and Rapid Endothelialization

Zhao

Feng

2020

Adv Healthcare Materials

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Cardiovascular devices have been widely applied in the clinical treatment of cardiovascular diseases. However, poor hemocompatibility and slow endothelialization on their surface still exist. Numerous surface engineering strategies have mainly sought to modify the device surface through physical, chemical, and biological approaches to improve surface hemocompatibility and endothelialization. The alteration of physical characteristics and pattern topographies brings some hopeful outcomes and plays a notable role in this respect. The chemical and biological approaches can provide potential signs of success in the endothelialization of vascular device surfaces. They usually involve therapeutic drugs, specific peptides, adhesive proteins, antibodies, growth factors and nitric oxide (NO) donors. The gene engineering can enhance the proliferation, growth, and migration of vascular cells, thus boosting the endothelialization. In this review, the surface engineering strategies are highlighted and summarized to improve hemocompatibility and rapid endothelialization on the cardiovascular devices. The potential outlook is also briefly discussed to help guide endothelialization strategies and inspire further innovations. It is hoped that this review can assist with the surface engineering of cardiovascular devices and promote future advancements in this emerging research field.

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“…The fixed HUVEC were fluorescence‐stained with CD31 antibody (Sigma, USA) and 4, 6‐diamino‐2‐phenyl indole (DAPI, Sigma, USA), and recorded by a fluorescence microscope (DMRX, Leica, Germany) [19]. The fluorescence intensity of CD31 on each sample was calculated by the software ipwin32 [31]. An MTT method was also performed to investigate the influence of the MgNP on HUVEC growth [32].…”

Section: Methodsmentioning

confidence: 99%

Preparing a novel magnesium‐doped hyaluronan/polyethyleneimine nanoparticle to improve endothelial functionalisation

Wang

Zhu

Wang

et al. 2020

IET nanobiotechnol.

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Nowadays, tissue engineering vascularisation has become an important means of organ repair and treatment of major traumatic diseases. Vascular endothelial layer regeneration and endothelial functionalisation are prerequisites and important components of tissue engineering vascularisation. The present researches of endothelial functionalisation mainly focus on tissue engineering scaffold preparation and implant surface modification. Few studies have reported the interaction of endothelial functionalisation and scaled materials, especially the nanomaterials. Magnesium (Mg), as an essential cytotropic active element in the human body, should promote the growth of endothelial cells. However, the authors' previous work found that the Mg in the alloys had a defect of delayed endothelialisation, which may be attributed to the non-uniform scales of the degradation products from Mg alloys. To validate this hypothesis and fabricate a novel nanomaterial for tissue engineering vascularisation, the authors prepared Mg-doped hyaluronan (HA)/polyethyleneimine (PEI) nanoparticles for endothelial cells testing. Their data showed that the Mg-doped HA/PEI nanoparticle with small scales (diameter <150 nm) presented better ability on improving endothelial cells growth, functionalisation and nitric oxide release.

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Preparation of a biomimetic ECM surface on cardiovascular biomaterials via a novel layer-by-layer decellularization for better biocompatibility

Cited by 31 publications

References 53 publications

Effects of degradation products of biomedical magnesium alloys on nitric oxide release from vascular endothelial cells

Effects of degradation products of biomedical magnesium alloys on nitric oxide release from vascular endothelial cells

Surface Engineering of Cardiovascular Devices for Improved Hemocompatibility and Rapid Endothelialization

Preparing a novel magnesium‐doped hyaluronan/polyethyleneimine nanoparticle to improve endothelial functionalisation

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