Preparation of a Magnetic-Field-Sensitive Hydrogel and Preliminary Study of Its Drug Release Behavior

Namdeo, Mini; Bajpai, Sunil; Kakkar, Shilpa

doi:10.1163/156856208x386372

Cited by 25 publications

(16 citation statements)

References 25 publications

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“…This goal has been accomplished by designing hybrid hydrogels or composites structures, in which each polymer component contributes to specific properties of the overall system and it allows to switch individually or in a concerted way the responsivities and functionalities of the hydrogels. Typically, but not exclusively, the response is a physical or chemical sudden change of external stimuli as pH, temperature, ionic strength, electric, or magnetic fields, light intensity …”

Section: Introductionmentioning

confidence: 99%

Multiresponsive Hyaluronan‐p(NiPAAm) “Click”‐Linked Hydrogels

Pasale

Cerroni

Ghugare

et al. 2014

Macromolecular Bioscience

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Combined reversible addition-fragmentation chain transfer (RAFT) and chemoselective "click" chemistry are used for assembling two polymeric chains into a hybrid network capable to respond simultaneously or separately to different external stimuli. An azido-derivative of hyaluronate is clicked together with a new telechelic RAFT-generated p(NiPAAm), carrying a propargyl function at both ends, suitable as macromolecular "clickable" cross-linker with controlled molecular weight. This hybrid system displays a multiresponsive behavior versus temperature, pH, and ionic strength, maintaining cumulative as well as separate sensitivities to the external stimuli. Hyaluronidase catalyzed degradation of the hydrogels, mimicking the extracellular matrix degradation process, is an additional asset for the use of this class of hydrogels as scaffold. Tumor cells, HT-29, grow on the surface of these hybrid hydrogels more than the healthy ones, as NIH3T3. This finding opens a road to micro- and nano-devices based on hyaluronic acid as a promising biopolymer to pursue localized drug delivery.

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Section: Introductionmentioning

confidence: 99%

Multiresponsive Hyaluronan‐p(NiPAAm) “Click”‐Linked Hydrogels

Pasale

Cerroni

Ghugare

et al. 2014

Macromolecular Bioscience

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“…The affected factors include shape [9], surface characteristics [10,11], solubility [12], molecular affinity [13,14], and sol-gel transition [15], etc., whereas the external triggers can be temperature [2,5,16], pH [4,17], ionic strength [18], or certain chemicals [19,20]. More recently, electric fields [21], magnetic fields [22], and light [23] have been used as additional stimuli for these polymers. Stimuli-responsive polymers have several promising applications because the stimuli can be applied or removed instantaneously, avoiding the delay associated with the diffusion of the stimulus in many other cases.…”

Section: Introductionmentioning

confidence: 99%

A smart hydrogel-based time bomb triggers drug release mediated by pH-jump reaction

Techawanitchai

Idota

Uto

et al. 2012

Science and Technology of Advanced Materials

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We demonstrate a timed explosive drug release from smart pH-responsive hydrogels by utilizing a phototriggered spatial pH-jump reaction. A photoinitiated proton-releasing reaction of o-nitrobenzaldehyde (o-NBA) was integrated into poly(N-isopropylacrylamide-co-2-carboxyisopropylacrylamide) (P(NIPAAm-co-CIPAAm)) hydrogels. o-NBA-hydrogels demonstrated the rapid release of protons upon UV irradiation, allowing the pH inside the gel to decrease to below the pK a value of P(NIPAAm-co-CIPAAm). The generated protons diffused gradually toward the non-illuminated area, and the diffusion kinetics could be controlled by adjusting the UV irradiation time and intensity. After irradiation, we observed the enhanced release of entrapped L-3,4-dihydroxyphenylalanine (DOPA) from the gels, which was driven by the dissociation of DOPA from CIPAAm. Local UV irradiation also triggered the release of DOPA from the non-illuminated area in the gel via the diffusion of protons. Conventional systems can activate only the illuminated region, and their response is discontinuous when the light is turned off. The ability of the proposed pH-jump system to permit gradual activation via proton diffusion may be beneficial for the design of predictive and programmable devices for drug delivery.

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“…Furthermore, controlled drug-release hydrogels responsive to external stimulus (e.g., the pH value [35], local tissue temperature [36,37], electric field [36,38], magnetic field [39][40][41], and specific disease-related enzymes [42,43]) are developed. These external conditions can be used as triggers to more specifically control drug release in a 'smart' manner.…”

Section: Hydrogelsmentioning

confidence: 99%

Hydrogels for Controlled Pulmonary Delivery

2013

Ther. Deliv.

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A significant number of research articles have focused on pulmonary delivery as an alternative administration route owing to no first-pass metabolism, low protease activity, thin epithelium barrier and large surface area in the lung system. Controlled release in the pulmonary delivery system further reduces loading dose, frequency of dosing and systemic side effects, and also increases duration of action and patient compliance. Compared with other microparticles used in controlled-release pulmonary administration, hydrogels (3D polymeric matrix networks) have recently been investigated due to their swelling and mucoadhesive properties that could help bypass pulmonary delivery barriers. This review introduces controlled-release drug delivery to the lung, followed by a summary of currently available approaches for controlled-release pulmonary drug delivery. Lastly, the origin, advantages, detailed applications and concerns of hydrogels in pulmonary delivery are discussed.

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Preparation of a Magnetic-Field-Sensitive Hydrogel and Preliminary Study of Its Drug Release Behavior

Cited by 25 publications

References 25 publications

Multiresponsive Hyaluronan‐p(NiPAAm) “Click”‐Linked Hydrogels

Multiresponsive Hyaluronan‐p(NiPAAm) “Click”‐Linked Hydrogels

A smart hydrogel-based time bomb triggers drug release mediated by pH-jump reaction

Hydrogels for Controlled Pulmonary Delivery

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