Abstract:Hantzsch reaction is classified as a one-pot, four-component process for the synthesis of 1,4-dihydropyridine and polyhydroquinoline derivatives. A green protocol for the promotion of the synthesis of polyhydroquinoline derivatives using polyethylene-glycol (PEG) as a green solvent in the absence of any catalysts under ultrasound irradiation at ambient temperature is demonstrated in this report. High to excellent yields, short reaction times, mild conditions, ambient temperature, inexpensive and availability of the substrates make this procedure an attractive methodology.
Keywords: Hantzsch reaction; PEG; Catalyst-free; DHPs derivative, ultrasound irradiationIntroduction: