Preparation of a novel ionic hybrid stationary phase by non-covalent functionalization of single-walled carbon nanotubes with amino-derivatized silica gel for fast HPLC separation of aromatic compounds

Aral, Hayriye; Çelik, Kadir Serdar; Aral, Tarık; Topal, Giray

doi:10.1016/j.talanta.2015.11.029

Cited by 20 publications

(19 citation statements)

References 45 publications

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“…In fact, SWCNTs have been found to contribute in the electrostatic interactions, dispersion forces, hydrogen bonding, π–π stacking and hydrophobic interactions with analytes [ 15 , 16 ]. An ionic hybrid stationary phase was synthesised by non-covalent immobilization of carboxylated-SWCNTs on amino-derivatized silica gel [ 22 , 142 ]. Then, SWCNTs-ionic hybrid was used to fill an empty column in HPLC [ 22 , 142 ].…”

Section: Swcnts and Mwcnts For Achiral Separation Of Pharmaceuticamentioning

confidence: 99%

“…An ionic hybrid stationary phase was synthesised by non-covalent immobilization of carboxylated-SWCNTs on amino-derivatized silica gel [ 22 , 142 ]. Then, SWCNTs-ionic hybrid was used to fill an empty column in HPLC [ 22 , 142 ]. The results showed fast and efficient separation of a wide range of aromatic compounds, including benzoic acid derivatives, chlorinated herbicides, nucleotides and Sudan dyes, with good peak asymmetry factor and high theoretical plate number [ 142 ].…”

Section: Swcnts and Mwcnts For Achiral Separation Of Pharmaceuticamentioning

confidence: 99%

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Application of Carbon Nanotubes in Chiral and Achiral Separations of Pharmaceuticals, Biologics and Chemicals

et al. 2017

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Carbon nanotubes (CNTs) possess unique mechanical, physical, electrical and absorbability properties coupled with their nanometer dimensional scale that renders them extremely valuable for applications in many fields including nanotechnology and chromatographic separation. The aim of this review is to provide an updated overview about the applications of CNTs in chiral and achiral separations of pharmaceuticals, biologics and chemicals. Chiral single-walled carbon nanotubes (SWCNTs) and multi-walled carbon nanotubes (MWCNTs) have been directly applied for the enantioseparation of pharmaceuticals and biologicals by using them as stationary or pseudostationary phases in chromatographic separation techniques such as high-performance liquid chromatography (HPLC), capillary electrophoresis (CE) and gas chromatography (GC). Achiral MWCNTs have been used for achiral separations as efficient sorbent objects in solid-phase extraction techniques of biochemicals and drugs. Achiral SWCNTs have been applied in achiral separation of biological samples. Achiral SWCNTs and MWCNTs have been also successfully used to separate achiral mixtures of pharmaceuticals and chemicals. Collectively, functionalized CNTs have been indirectly applied in separation science by enhancing the enantioseparation of different chiral selectors whereas non-functionalized CNTs have shown efficient capabilities for chiral separations by using techniques such as encapsulation or immobilization in polymer monolithic columns.

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Section: Swcnts and Mwcnts For Achiral Separation Of Pharmaceuticamentioning

confidence: 99%

Section: Swcnts and Mwcnts For Achiral Separation Of Pharmaceuticamentioning

confidence: 99%

Application of Carbon Nanotubes in Chiral and Achiral Separations of Pharmaceuticals, Biologics and Chemicals

et al. 2017

View full text Add to dashboard Cite

show abstract

“…In fact, SWCNTs have been found to contribute in the electrostatic interactions, dispersion forces, hydrogen bonding, π-π stacking and hydrophobic interactions with analytes [15,16]. An ionic hybrid stationary phase was synthesised by non-covalent immobilization of carboxylated-SWCNTs on amino-derivatized silica gel [22,141]. Then, SWCNTs-ionic hybrid was used to fill an empty column in HPLC [22,141].…”

Section: Swcnts and Mwcnts For Achiral Separation Of Pharmaceuticals mentioning

confidence: 99%

“…An ionic hybrid stationary phase was synthesised by non-covalent immobilization of carboxylated-SWCNTs on amino-derivatized silica gel [22,141]. Then, SWCNTs-ionic hybrid was used to fill an empty column in HPLC [22,141]. The results showed fast and efficient separation of a wide range of aromatic compounds, including benzoic acid derivatives, chlorinated herbicides, nucleotides and Sudan dyes, with good peak asymmetry factor and high theoretical plate number [141].…”

Section: Swcnts and Mwcnts For Achiral Separation Of Pharmaceuticals mentioning

confidence: 99%

“…Then, SWCNTs-ionic hybrid was used to fill an empty column in HPLC [22,141]. The results showed fast and efficient separation of a wide range of aromatic compounds, including benzoic acid derivatives, chlorinated herbicides, nucleotides and Sudan dyes, with good peak asymmetry factor and high theoretical plate number [141]. Sudan dyes, however, contain highly conjugated aromatic structures and hence they form strong π-π interactions with SWCNTs which reduced the theoretical plate number and the peak sharpness [141].…”

Section: Swcnts and Mwcnts For Achiral Separation Of Pharmaceuticals mentioning

confidence: 99%

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Application of Carbon Nanotubes in Chiral and Achiral Separations of Pharmaceuticals, Biologics and Chemicals

Hemasa

Naumovski

Maher

et al. 2017

Preprint

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Carbon nanotubes (CNTs) possess unique mechanical, physical, electrical and absorbability properties coupled with their nanometer dimensional scale that renders them extremely valuable for applications in many fields including nanotechnology and chromatographic separation. The aim of this review is to provide an updated overview about the applications of CNTs in chiral and achiral separations of pharmaceuticals, biologics and chemicals. Chiral SWCNTs and MWCNTs have been directly applied for the enantioseparation of pharmaceuticals and biologicals by using them as stationary or pseudostationary phases in chromatographic separation techniques such as high-performance liquid chromatography (HPLC), capillary electrophoresis (CE) and gas chromatography (GC). Achiral MWCNTs have been used for achiral separations as efficient sorbent objects in solid-phase extraction techniques of biochemicals and drugs. Achiral SWCNTs have been applied in achiral separation of biological samples. Achiral SWCNTs and MWCNTs have been also successfully used to separate achiral mixtures of pharmaceuticals and chemicals. Collectively, functionalized CNTs have been indirectly applied in separation science by enhancing the enantioseparation of different chiral selectors whereas, non-functionalized CNTs have shown efficient capabilities for chiral separations by using techniques such as encapsulation or immobilization in polymer monolithic columns.

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Fabrication of microporous organic network@silica composite for high‐performance liquid chromatographic separation of drugs and proteins

2021

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Microporous organic networks (MONs) that exhibit good stability and hydrophobicity are promising candidates for performing HPLC separation of small organic compounds. However, their applications in separating large analytes as well as biomolecules are still limited by the microporous nature of MONs. Herein, we demonstrated the fabrication of a MON-functionalized silica (MON@SiO 2 ), exhibiting micro and mesopores for the HPLC separations of small drugs as well as large analytes, such as flavones, nonsteroidal anti-inflammatory drugs (NSAIDs), endocrine disrupting chemicals (EDCs), and proteins. MON was successfully modified on SiO 2 microspheres to yield the uniform and mono-dispersed MON@SiO 2 . The separation mechanisms and performance of the MON@SiO 2 packed column were evaluated for a wide range of analytes, including neutral, acidic, basic compounds, drugs, and proteins. Compared with commercial C18 and SiO 2 -NH 2 packed columns, the proposed MON@SiO 2 column afforded superior performance in the separations of flavones, NSAIDs, EDCs, and proteins. Moreover, the MON@SiO 2 column also offered good repeatability with intraday RSDs (n = 7) of <0.1%, <2.0%, <2.3%, and <0.7% for the retention time, peak height, peak area, and half peak width, respectively, for separating EDCs. This work proved the potential of using MONs in the HPLC separations of drugs and proteins.

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Preparation of a novel ionic hybrid stationary phase by non-covalent functionalization of single-walled carbon nanotubes with amino-derivatized silica gel for fast HPLC separation of aromatic compounds

Cited by 20 publications

References 45 publications

Application of Carbon Nanotubes in Chiral and Achiral Separations of Pharmaceuticals, Biologics and Chemicals

Application of Carbon Nanotubes in Chiral and Achiral Separations of Pharmaceuticals, Biologics and Chemicals

Application of Carbon Nanotubes in Chiral and Achiral Separations of Pharmaceuticals, Biologics and Chemicals

Fabrication of microporous organic network@silica composite for high‐performance liquid chromatographic separation of drugs and proteins

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