Preparation of a polymethoxyflavone-rich fraction (PRF) of Citrus sunki Hort. ex Tanaka and its antiproliferative effects

Immature Citrus sunki Peel Extract Exhibits Antiobesity Effects by .BETA.-Oxidation and Lipolysis in High-Fat Diet-Induced Obese Mice

“…The animals were housed in plastic cages (two/cage) and given free access to drinking water and food. After adaptation, the C57BL/6 mice (now 5 weeks old; 22.6±1.2 g) were randomly divided into three groups of 10 Biochemical Analysis After 70 d, the mice were killed by ether anesthesia overdose. Blood samples were drawn from the abdominal aorta into a vacuum tube and allowed to clot at room temperature for 30 min.…”

“…These flavonoids have various biological activities, such as anti-atherogenic effects, anti-inflammatory effects, and anticancer activity. [8][9][10] The peel of Citrus sunki HORT. ex TANAKA is a rich source of flavanones, as well as many PMFs, which are very rare in other plants.…”

“…ex TANAKA is a rich source of flavanones, as well as many PMFs, which are very rare in other plants. [10][11][12] It has been reported that Citrus phytochemicals, such as synephrine and auraptene, exhibited the anti-obesty properties by enhancing the lipolysis in vitro and in vivo. 13,14) However, the effects of immature fruit peel extract on lipid metabolism have not been fully evaluated.…”

Effects of Sinensetin on Lipid Metabolism in Mature 3T3‐L1 Adipocytes

“…The fruit peel of Citrus sunki Hort. ex Tanaka is a rich source of polymethoxylated flavones (PMFs) and has been used in traditional Asian medicine for centuries to treat indigestion and to improve bronchial and asthmatic conditions (Ko et al ., ). It has been reported that two common PMFs, nobiletin and tangeretin, have the ability to modulate lipid metabolism (Kurowska et al ., ; Saito et al ., ).…”

Sinensetin Enhances Adipogenesis and Lipolysis by Increasing Cyclic Adenosine Monophosphate Levels in 3T3-L1 Adipocytes

“…12,13) We previously described eight PMFs from C. sunki. 14) Among these, two common PMFs (nobiletin and tangeretin) have been reported to modulate lipid metabolism. Nobiletin stimulates lipolysis in 3T3-L1 cells via activation of signaling cascades mediated by cAMP pathway.…”