Preparation of a polyurethane scaffold for tissue engineering made by a combination of salt leaching and freeze-drying of dioxane

Abstract

Preparation of a polyurethane scaffold for tissue engineering made by a combination of salt leaching and freeze-drying of dioxane Heijkants, RGJC; Van Tienen, TG; De Groot, JH; Pennings, AJ; Buma, P; Veth, RPH; Schouten, AJ Take-down policy If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim. In the past several types of synthetic porous materials have been made as meniscus reconstruction materials. Most of these materials lacked a good combination between suitable mechanical properties and a high interconnectivity. In this work porous scaffolds were made from the polyurethane Estane 5701-F1 by freeze drying of a dioxane and water solution in combination with salt leaching. It was possible to obtain very porous scaffolds with a very high interconnectivity. Porosity, pore size and interconnectivity can be independently adjusted by varying the amount of water, porogen size and the amount of porogen used. The obtained compression moduli of the scaffolds were between 40 kPa and 400 kPa with a variation in porosity between 72 and 87%. These scaffolds are very suitable for the use as meniscus replacement materials. C 2006 Springer Science + Business Media, Inc.

Porous poly-ether ether ketone (PEEK) manufactured by a novel powder route using near-spherical salt bead porogens: Characterisation and mechanical properties

“…The production of porous structures via the removal of a pore forming or space holding (porogen) phase within a solid structure offers the greatest potential to control pore size and porosity whilst achieving a high level of pore homogeneity [14][15][16][17]. A number of researchers have used salt (NaCl) porogens in combination with several different processing methods to produce porous polymer structures: for instance, gas foaming [18]; concurrent electro-spinning [19], gas anti-solvent precipitation [20] and phase-separation [21], that tend to exhibit a wide range of irregularly-sized and shaped pores.…”

Analysis of frictional behavior and changes in morphology resulting from cartilage articulation with porous polyurethane foams

“…In these studies we have characterized the frictional properties and resulting changes in tissue structure that occur with PUR meniscal scaffolds that have been used for soft tissue implants. [33][34][35][36][37][38][39] In these scaffolds, significant tissue ingrowth occurs in vivo [40][41][42][43][44][45][46] and this neocartilage may be Figure 8. Representative histological images of cartilage samples following articulation against PUR with PBS or ESF used as lubricants demonstrating surface damage and proteoglycan loss.…”

“…25 Of particular interest are porous polyurethane foams (PUR), which have been extensively evaluated as meniscal replacement materials. [33][34][35][36][37][38][39] PUR enables infiltration of cells into the material and subsequent generation of fibrocartilaginous tissue in in vivo rat and dog studies. [40][41][42][43][44][45][46] While these results are very promising, in PUR meniscal repair studies, cartilage damage similar to menisectomized controls was found over 6 months of implantation.…”

Techniques for fabrication and construction of three-dimensional scaffolds for tissue engineering

“…In the last decade, various fabrication methods for construction of three-dimensional biomimetic scaffolds, including electrospinning, [1][2][3] phase-separation, 4,5 freeze drying, 6,7 and self-assembly, 8,9 have been developed for tissue engineering and regenerative medicine. These scaffolds can mimic the architecture of the native extracellular matrix at the nanoscale level (eg, hierarchical architecture formed with nanofibers and nanopores), which provides the initial space for regeneration of new tissue.…”