Preparation of alginate beads for floating drug delivery system: effects of CO2 gas-forming agents

Choi, Byeong Yoon; Park, H.J.; Hwang, Sung Joo; Park, J.B.

doi:10.1016/s0378-5173(02)00054-6

Cited by 260 publications

(153 citation statements)

References 32 publications

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“…Moreover, the study is designed in a way that explored the influence of different formulation variables on physical characters of the developed dosage form and to evaluate the pharmacokinetics of the drug from the developed dosage form compared to Daonil ® tablets as a marketed reference drug product [7][8][9][10] . MATERIALS The following materials have been utilized during the experimental part of the research:…”

Section: Introductionmentioning

confidence: 99%

Gastroretentive Controlled Release Glibenclamide Oral Tablet Formulation

Alkarib¹,

Nur²

2017

Am J Drug Deliv

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Hydroxypropyl methylcellulose (HPMC-4000cps, fixed amount), various contents of calcium hydroxide, stearyl alcohol, magnesium stearate, different drug: PVP ratios and altered tablet hardness were used to design floating tablet formulation capable to deliver glibenclamide in a sustained manner. Both full factorial and Box-Wilson designs, in consecutive manner, were used to investigate for the influences of these formulation variables on the developed dosage form performance and drug release.Tablet hardness has revealed an influential effect on tablet onset of floating, and drug release was shown to be more evident in the initial phase (p<0.05). Loading level of calcium hydroxide, stearyl alcohol and tablet swellability all have showed profound enhancing effects on duration of tablet buoyancy and drug release.Glibenclamide release from tablets of the invention was shown to follow the anomalous type (n=0.8212-1.0244). Application of statistical and mathematical modeling has enabled the optimization of the developed tablet formulation to meet selective constraints for floating, hardness and drug release.The optimized buoyant tablet formulation with highest CI revealed hardness of 50 N, immediate onset of floating and floating duration >6 hours. Concerning drug release, the formula showed evidence of 25 and 84% drug release after 1 and 6 hours, respectively, with T50% of 3 hours. Moreover, release kinetics of the drug from the optimized formula was shown to be near the desired zero order type of release (n=0.8897 or 0.0132; r2=0.9993). The in vivo dosage form residence time study in six human subjects demonstrated that the developed tablet formulation retained in the stomach for more than four hours under fasting conditions.Comparative bioavailability study revealed that floating tablets showed 2-2.5 times increase in AUC (p≤ 0.1) indicating the sustained release tendency of the drug from the floating tablet formulation.The three months based stability study indicated that the drug and the dosage form retained their initial physical characters in both accelerated and normal conditions for the test duration as far as blister pack is considered.

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Section: Introductionmentioning

confidence: 99%

Gastroretentive Controlled Release Glibenclamide Oral Tablet Formulation

Alkarib¹,

Nur²

2017

Am J Drug Deliv

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“…Several reports are available, in which alginate is used in combination with polyethylene glycol and polyethylene oxide for various biomedical applications. [25][26][27][28] The rate of drug release from hydrophilic matrix depends on various factors such as nature of polymers, solubility of drug, polymer content, particle size of drug and types of filler used in the formulation. 14 The adjustment of polymer concentration, viscosity grade and addition of different types and levels of excipients to the polymer matrix can modify the kinetics of drug release.…”

Section: Introductionmentioning

confidence: 99%

“…The most commonly used pore forming agents are NaHCO 3 and CaCO 3 . 2,8,23,27 In the present study we prepared the floating beads containing sodium alginate/PEG or PEO loaded with ciprofloxacin hydrochloride. In order to investigate the release kinetics of the drug from the blended beads, the ratio of the polymers and amount pore forming agent were varied.…”

Section: Introductionmentioning

confidence: 99%

Sodium Alginate with PEG/PEO Blends as a Floating Drug Delivery Carrier – In vitro Evaluation

C¹,

Swamiappan²

2016

Adv Pharm Bull

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“…The feasible approaches for achieving a prolonged and predictable drug delivery are control the gastric residence time (GRT), using gastric retentive dosage form that can provide newer therapeutic option [1,2] . Floating drug and bioadhesive drug delivery systems are widely used techniques for gastroretention [3,4]. Floating drug delivery systems have a bulk density lower than gastric fluids and thus remain buoyant in the stomach for a prolonged period of time, without affecting the gastric emptying rate.…”

Section: Introductionmentioning

confidence: 99%

“…Floating drug delivery systems have a bulk density lower than gastric fluids and thus remain buoyant in the stomach for a prolonged period of time, without affecting the gastric emptying rate. While the system is floating on the gastric contents, the drug is released slowly at a desired rate from the system and remaining part of the residual system is slowly emptied from the stomach and enhanced GRT of the drug [5][6][7]. This study was envisaged to develop mucoadhesive gastric retentive formulation of amoxicillin in order to achieve targeted release of doi:10.5138/ ijdd.2010.0975.0215.03062 ©arjournals.org, All rights reserved.…”

Section: Introductionmentioning

confidence: 99%

Formulation and In Vitro evaluation of pH sensitive oil entrapped buoyant beads of amoxicillin.

Tripathi¹,

Singh²

2011

Int J Drug Del

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A gastro retentive pH sensitive system has been a frontier approach to release the drug in controlled manner in stomach and duodenum. The aim of the study is to develop reliable formulation of amoxicillin which will release the drug in controlled way at specific site with acidic pH stimulus present in the gastric region. In the present investigation pectin based oil entrapped micro gel beads were prepared by ionic gelation technique using castor oil and mineral oil. The developed beads were evaluated in term of diameter, surface morphology, floating lag time, encapsulation efficiency, in vitro drug release. Prepared microbeads were regular and spherical in shape. The formulation exhibited sustained release profile and was best fitted in the Peppas model with n < 0.45. Subsequent coating of microbeads exhibited zero-order sustained pattern of amoxicillin release up to 8 hrs.The Results provides evidence that optimized gel bead may be used to incorporate antibiotics like amoxicillin and may be effective when administered locally in the stomach to cure microbial infection.

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Preparation of alginate beads for floating drug delivery system: effects of CO2 gas-forming agents

Cited by 260 publications

References 32 publications

Gastroretentive Controlled Release Glibenclamide Oral Tablet Formulation

Gastroretentive Controlled Release Glibenclamide Oral Tablet Formulation

Sodium Alginate with PEG/PEO Blends as a Floating Drug Delivery Carrier – In vitro Evaluation

Formulation and In Vitro evaluation of pH sensitive oil entrapped buoyant beads of amoxicillin.

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