Preparation of an efficient and safe polymeric-magnetic nanoparticle delivery system for sorafenib in hepatocellular carcinoma

Tom, Greeshma; Philip, Sheena; Isaac, R. S. Rimal; Praseetha, P.K.; Jiji, S.G.; Asha, V.V.

doi:10.1016/j.lfs.2018.04.046

Cited by 30 publications

(13 citation statements)

References 51 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Inhibition of Ras/Raf and PI3K/Akt/mTOR pathways regulates cell cycle of HCC, inhibits cell proliferation, promotes apoptosis, and enhances radiosensitivity of HCC [28][29][30]. BEZ235 (PI3K/mTOR pathway inhibitor) causes significant cell death [29][30][31], but low concentrations of the drug in the target tissue results in poor therapeutic efficacy and need for more frequent dosing; on the other hand, high drug concentrations may cause toxicity, including stomatitis, hyperglycemia, non-infectious pneumonia, and immunosuppression.…”

Section: Discussionmentioning

confidence: 99%

RETRACTED ARTICLE: The PI3K/mTOR dual inhibitor BEZ235 nanoparticles improve radiosensitization of hepatoma cells through apoptosis and regulation DNA repair pathway

Tang

Xie

et al. 2020

Nanoscale Res Lett

View full text Add to dashboard Cite

Polymer materials encapsulating drugs have broad prospects for drug delivery. We evaluated the effectiveness of polyethylene glycol-poly (lactic-co-glycolic acid) (PLGA-PEG) encapsulation and release characteristics of PI3K/mTOR inhibitor NVP-BEZ235 (BEZ235). We proposed a strategy for targeting radiosensitization of liver cancer cells. The biocompatibility, cell interaction, and internalization of Glypican-3 (GPC3) antibody-modified, BEZ235-loaded PLGA-PEG nanoparticles (NP-BEZ235-Ab) in hepatoma cells in vitro were studied. Also, the cell killing effect of NP-BEZ235-Ab combined with γ-ray cell was evaluated. We used confocal microscopy to monitor nanoparticle-cell interactions and cellular uptake, conducted focus-formation experiments to analyze the synergistic biological effects of NP-BEZ235-Ab and priming, and studied synergy in liver cancer cells using molecular biological methods such as western blotting. We found that PLGA-PEG has good loading efficiency for BEZ235 and high selectivity to GPC3-positive HepG2 liver cancer cells, thus documenting that NP-BEZ235-Ab acts as a small-molecule drug delivery nanocarrier. At the nominal concentration, the NP-BEZ235-Ab nanoformulation synergistically kills liver cancer cells with significantly higher efficiency than does the free drug. Thus, NP-BEZ235-Ab is a potential radiosensitizer.

show abstract

Section: Discussionmentioning

confidence: 99%

RETRACTED ARTICLE: The PI3K/mTOR dual inhibitor BEZ235 nanoparticles improve radiosensitization of hepatoma cells through apoptosis and regulation DNA repair pathway

Tang

Xie

et al. 2020

Nanoscale Res Lett

View full text Add to dashboard Cite

show abstract

“…Several studies have recently evaluated magnetic NPs loaded with different drugs (5,6). For example, Cicha et al 7evaluated mitoxantrone-carrying SPIONs and the drug released from SPIONs.…”

Section: In Targeted Therapy the Development Of Magneticallymentioning

confidence: 99%

Synthesis and Investigation of the Curcumin-Loaded Magnetic Lipid Nanoparticles and Their Cytotoxicity Assessment on Human Breast Carcinoma Cell Line

Karami

Rostamizadeh

Shademani

et al. 2020

Jundishapur J Nat Pharm Prod

View full text Add to dashboard Cite

Chemotherapy fails to eradicate cancer cells, mainly due to the lack of selective drug accumulation into the tumor site, which can affect healthy cells, as well. In this research, we studied the magnetite nanostructured lipid carriers (NLCs) for targeted delivery of curcumin into breast cancer cells. Superparamagnetic iron oxide nanoparticles (SPIONs) were prepared using coprecipitation method by mixing FeCl2 and FeCl3 in a suitable ratio in alkaline media. The resultant ferrofluid was very stable and possessed high magnetic properties. To prepare SPIONs containing NLCs (NLC-SPIONs), cetyl palmitate and cod-liver oil, Tween 80 and span60 were used as solid lipid, liquid lipid, surfactant, and co-surfactant, respectively. Curcumin as an anticancer drug was loaded into NLC-SPIONs (CUR-NLC-SPIONs) and its characteristics, including particle size, zeta potential, polydispersity index (PDI), drug entrapment efficacy, drug-loading capacity, and thermal stability were evaluated. The results showed that CUR-NLC-SPIONs had a mean particle size of 166.7 ± 14.20 nm, mean zeta potential of-27.6 ± 3.83 mv, and PDI of 0.24 ± 0.14. Encapsulation efficiency for all prepared nanoparticles (NPs) was 99.95 ± 0.015% and drug-loading capacity was 3.76 ± 0.005%. Morphological studies were carried out by transmission electron microscopy (TEM) indicating spherical morphology of the NPs. 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay measurements on cell viability proved that the synthesized CUR-NLC-SPIONs possess a better cytotoxic activity against human breast cancer cells compared with free curcumin. This new drug delivery system, which benefits from superparamagnetic properties may serve as a suitable platform for developing new biocompatible drug carriers and with a potential to use in targeted cancer therapy.

show abstract

“…However, the drug dose ratio at tumor site is uncontrollable and can't be fixed at the optimal synergistic ratio owning to a corresponding differential pharmacokinetic profile and biodistribution [ 5 ]. Moreover, the solubility of SFN and TPL in water is low and both drugs have certain toxicity [ 6 – 8 ]. The nano drug co-delivery system (NDCDS) is expected to solve the problems above with minimized side effects and optimized therapeutic efficacy [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

Sorafenib and triptolide loaded cancer cell-platelet hybrid membrane-camouflaged liquid crystalline lipid nanoparticles for the treatment of hepatocellular carcinoma

Yang

Han

et al. 2021

J Nanobiotechnol

View full text Add to dashboard Cite

In addition to early detection, early diagnosis, and early surgery, it is of great significance to use new strategies for the treatment of hepatocellular carcinoma (HCC). Studies showed that the combination of sorafenib (SFN) and triptolide (TPL) could reduce the clinical dose of SFN and maintain good anti-HCC effect. But the solubility of SFN and TPL in water is low and both drugs have certain toxicity. Therefore, we constructed a biomimetic nanosystem based on cancer cell-platelet (PLT) hybrid membrane camouflage to co-deliver SFN and TPL taking advantage of PLT membrane with long circulation functions and tumor cell membrane with homologous targeting. The biomimetic nanosystem, SFN and TPL loaded cancer cell-PLT hybrid membrane-camouflaged liquid crystalline lipid nanoparticles ((SFN + TPL)@CPLCNPs), could simultaneously load SFN and TPL at the molar ratio of SFN to TPL close to 10:1. (SFN + TPL)@CPLCNPs achieved long circulation function and tumor targeting at the same time, promoting tumor cell apoptosis, inhibiting tumor growth, and achieving a better "synergy and attenuation effect", which provided new ideas for the treatment of HCC. Graphical Abstract

show abstract

Preparation of an efficient and safe polymeric-magnetic nanoparticle delivery system for sorafenib in hepatocellular carcinoma

Cited by 30 publications

References 51 publications

RETRACTED ARTICLE: The PI3K/mTOR dual inhibitor BEZ235 nanoparticles improve radiosensitization of hepatoma cells through apoptosis and regulation DNA repair pathway

RETRACTED ARTICLE: The PI3K/mTOR dual inhibitor BEZ235 nanoparticles improve radiosensitization of hepatoma cells through apoptosis and regulation DNA repair pathway

Synthesis and Investigation of the Curcumin-Loaded Magnetic Lipid Nanoparticles and Their Cytotoxicity Assessment on Human Breast Carcinoma Cell Line

Sorafenib and triptolide loaded cancer cell-platelet hybrid membrane-camouflaged liquid crystalline lipid nanoparticles for the treatment of hepatocellular carcinoma

Contact Info

Product

Resources

About