Preparation of antimicrobial sutures by preirradiation grafting onto polypropylene monofilament

Abstract

Antimicrobial sutures were prepared by the radiation grafting of acrylonitrile monomer onto polypropylene (PP) monofilament. The grafted sutures were subsequently hydrolyzed to transform nitrile groups into carboxylic groups for the immobilization of antimicrobial drug, tetracycline hydrochloride (TC). The modified sutures show continuous release of drug for a period of 4–5 days. The antimicrobial activity of the sutures was determined against both Gram positive and Gram negative bacteria by the zone of inhibition technique. Zone of inhibition was observed around the drug‐containing sutures in the plate inoculated with Escherichia coli (E. coli), Klebsiella pneumonea (K. pneumonea), and Staphylococcus aureus (S. aureus). The results of infection studies in albino rats against S. aureus showed no infection even after fourth postoperative day of surgery. This is because of the release of the TC drug at the site of injury, which inhibits the bacterial growth. Copyright © 2008 John Wiley & Sons, Ltd.

Combining in the melt physical and biological properties of poly(caprolactone) and chlorhexidine to obtain antimicrobial surgical monofilaments

“…One approach is to provide the polymer with antimicrobial properties in an "offline" preparation process. In this case, the thread is superficially coated using a specific antimicrobial component previously dissolved in a solvent (Blaker et al 2004;Dubas et al 2011;Harnet et al 2009;Gupta et al 2007Gupta et al , 2008Pollini et al 2009;Saxena et al 2011;Zurita et al 2006). Another approach is to add the biocide agent in the polymers "online", i.e.…”

Nanostructures and Nanostructured Networks for Smart Drug Delivery

“…Grafting of MAA to medical grade silk suture and twisted yarn has been shown to be useful for the loading of microbicide doses of 8-hydroxy quinoline [280]. Similarly, the graft polymerization of 1-vinylimidazole and of acrylonitrile onto polypropylene monofilaments rendered sutures that can elute ciprofloxacin or tetracycline hydrochloride in a sustained way under in vivo conditions [281,282]. Monomers suitable for endowing polypropylene and polyethylene substrates with affinity for vancomycin were screened using isothermal titration calorimetry in order to establish a rational surface functionalization protocol [283].…”

Stimuli–responsive networks grafted onto polypropylene for the sustained delivery of NSAIDs

“…Depending on the chemical structure of the substrate and the monomers to be grafted, different levels of performance can be achieved. Most research has focused on the grafting of acrylic polymers to silk, polypropylene (PP) or polyethylene (PE) with the aim of enhancing the adsorption of antimicrobial agents and inhibiting the growth of bacteria [16][17][18]. Grafting of cyclodextrins has also been explored for the uptake of drugs possessing hydrophobic moieties suitable for forming inclusion complexes [19][20].…”