Preparation of Bioactive Mesoporous Calcium Phosphate Granules

Musskaya, O. N.; Кулак, А. И.; Крутько, В. К.; Lesnikovich, Yu. A.; Казбанов, В. В.; Zhitkova, N. S.

doi:10.1134/s0020168518020115

Cited by 20 publications

(4 citation statements)

References 6 publications

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“…Методом прямой реплики пенополиуретановых (ППУ) матриц (марки GranuFoam, Китай) пористостью 65 70  % и размером пор Ca PO OH [16,17] и моногидрата дигидрофосфата кальция…”

Section: материалы и методыunclassified

Modification of Calcium Phosphate Foam Ceramics With Bioapatite in SBF Solution

Крутько¹,

Маслова²,

Мусская³

et al. 2021

Physical and Chemical Aspects of the Study of Clusters, Nanostructures and Nanomaterials

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Получена многофазная кальцийфосфатная пенокерамика, представленная Д -трикальцийфосфатом (65 %) и Д -пирофосфатом кальция (25 %), включающая гидроксиапатит ( 5 %) и а -трикальцийфосфат ( 5 %), пористостью 60 - 64 % со сквозной архитектурой пенополиуретана. Нанесение слоя гидроксиапатита приводило к увеличению содержания гидроксиапатита до 25 %, а -трикальцийфосфата до 40 %, и повышению статической прочности до 0,03 МПа при снижении пористости до 49 %. Нанесение второго слоя гидроксиапатита способствовало повышению содержания гидроксиапатита до 40 %, статическая прочность достигала 0,05 МПа при пористости 40%. Формирование биоапатита в виде слоя «пеносфер» размером от 2 до 10 мкм происходило в процессе модифицирования всех видов пенокерамики в растворе SBF в течение 21 - 28 суток. Модифицированная кальцийфосфатная пенокерамика, обогащенная а -трикальцийфосфатом и гидроксиапатитом, характеризовалась максимальной статической прочностью 0,08 МПа при пористости 38%. The multiphase calcium phosphate foam ceramics, represented by р -tricalcium phosphate (65 %) and р -calcium pyrophosphate (25 %), including hydroxyapatite (5 %) and а -tricalcium phosphate (5%), with 60 - 64% porosity and a through architecture of polyurethane foam was obtained. The application of a layer of hydroxyapatite led to an increase in the content of hydroxyapatite to 25 %, а -tricalcium phosphate to 40%, and an increase in static strength to 0,03 MPa with a decrease in porosity to 49%. The application of the second layer of hydroxyapatite promoted an increase in the content of hydroxyapatite to 40%, the static strength reached 0,05 MPa at a porosity 40 %. The bioapatite formation in the shape of «foam spheres» with a size from 2 to 10 pm occurred in the process of modifying all types of foam ceramics in a SBF solution during 21 - 28 days. The modified calcium phosphate foam ceramics enriched with а -tricalcium phosphate and hydroxyapatite, was characterized by the maximum static strength 0,08 MPa at a porosity 38 %.

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Section: материалы и методыunclassified

Modification of Calcium Phosphate Foam Ceramics With Bioapatite in SBF Solution

Крутько¹,

Маслова²,

Мусская³

et al. 2021

Physical and Chemical Aspects of the Study of Clusters, Nanostructures and Nanomaterials

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“…Incorporating calcium phosphate particles into polymers aims to mimic the human bone structure; however, only a few reported calcium phosphate/polymer composites have demonstrated sufficient mechanical strength for bone tissue scaffolds. To achieve anisotropic mechanical properties, controlled dispersion and alignment of calcium phosphate particles with specific size and morphology in the polymer are essential [4]. Particle size and shape also impact biological responses such as cell adhesion and bone regeneration.…”

Section: Introductionmentioning

confidence: 99%

Mineralization of Octacalcium Phosphate under Magnetic Field

He,

Xue,

Qian

et al. 2024

Crystals

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The mineralization of octacalcium phosphate (OCP) crystals in gel media was studied in the presence of a magnetic field. OCP crystal growth was found to be dependent on mineralization temperature, mineralization time, and the magnetic field. Higher temperatures significantly reduced the mineralization time, which is crucial for directional growth of OCP crystals. The growth of OCP crystals was accelerated by the applied magnetic field, while OCP crystals generated in the presence of a magnetic field exhibited increased length and width of oriented growth. This study provides valuable insights into the influence of mineralization factors in bioprocessing-inspired manufacturing processes.

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“…Синтезы фосфатов кальция осуществляли по известным методикам [5,16] из растворов CaCl 2 и (NH 4 ) 2 HPO 4 при комнатной температуре. Осаждение ДКФД проводили при pH 6 и мольном соотношении Ca/P 1,00; ТКФ -при pH 9 и Ca/P 1,50; ГА -при pH 11 и Ca/P 1,67.…”

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