Composites based on calcium phosphates in the matrix of biopolymer (citrated plasma and fibrin) were synthesized in neutral and alkaline medium. At pH 7 brushite composites were obtained, whereas at pH 11 amorphized hydroxyapatite was precipitated. Disruption of precipitation conditions led to the formation of tricalcium phosphate impurity, which was detected by XRD after thermal treatment of composites at 800 °C. Composition and morphology of calcium phosphates did not depend on biopolymer nature. To determine bioactivity degree, composites were incubated in model Simulated Body Fluid (SBF) for 75 days. It was found that composites based on amorphized hydroxyapatite incorporated in biopolymer matrix have maximum growth of biomimetic layer of apatite.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.