Preparation of bioactive porous HA/PCL composite scaffolds

Bone-Biomimetic Biomaterial and Cell Fate Determination

“…For ceramic scaffolds, attempts have been made to reduce brittleness and enhance mechanical performance mainly by reinforcement with coating layers of polymers and/or ceramics. Several biocompatible and biodegradable polymers have been used to coat ceramic scaffolds, including poly(lactic-co-glycolic acid) (PLGA) (Miao et al 2007(Miao et al , 2008, poly(D,L-lactic acid) (PDLLA) Tian et al 2008;Lu et al 2008b;Zhao et al 2009), polycaprolactone (PCL) (Kim et al 2004;Zhao et al 2008;RoohaniEsfahani et al 2011), poly(3-hydroxybutyrate) (PHB) (Bretcanu et al 2009) and silk fibroin (Wu et al 2010;Roohani-Esfahani et al 2012;Li et al 2013b). Some of these polymer coatings have an additional ceramic component in the form of powder or nanoparticles for bioactivity and further strength enhancement (Miao et al 2007;Roohani-Esfahani et al 2011).…”

Study on Fabrication and Properties of Porous HA/SiO2Composite Coating on Titanium Substrate

“…(electrophoretic deposition, EPD)制备 HA 涂层, 相比于 其它钛表面涂覆 HA 涂层的方法, 如等离子喷涂法 [2] 、 溶胶-凝胶法 [3,4] 、 电沉积法 [5] 等, EPD 表现出许多显著的 优点 [6] [7] . 此外, 多孔结构可为纤 维细胞、 骨细胞向生物陶瓷材料中生长提供信道和空间, 增加了新骨与植入材料的结合面积 [8,9] .…”

Development of bioactive glass based scaffolds for controlled antibiotic release in bone tissue engineering via biodegradable polymer layered coating

“…3,10 Therefore, several natural-and synthetic-derived biodegradable polymers have been explored as the organic component for development of composite scaffolds, such as collagen, [24][25][26] gelatin, [27][28][29] chitosan, 2,18,19,30 alginate, [29][30][31] and polyesters. 16,[32][33][34][35] As early reported by Yaylao glu et al, 17 CaP/gelatin composite scaffolds have been loaded with gentamicin for in-situ drug delivery enhanced bone tissue engineering. Continuous release of the drug upon 4 weeks in vivo was observed with the release rate depending on the a) Author to whom correspondence should be addressed; electronic mail: aldo.boccaccini@ww.uni-erlangen.de degradation rate of the gelatin component.…”